Teaching interests relate to the development of problem oriented courseware and web based learning aids which could have application in veterinary colleges world wide. Research interests center around stem cell biology. Current directions of research pertain to the development of multipotent stem cell lines in a large animal model which could be used for gene therapy (e.g. treatment of diabetes). Exploring stem cell treatment in a large animal model is a needed step toward our ultimate goal of translating this form of therapy to humans.
Selected Publications
Ph.D. Thesis
Clarkson, CE, Ph.D. Thesis: Tissue Culture as a Means of Establishing an Epidermal-Implant Union in Percutaneous Implants. Department of Veterinary Anatomy, College of Veterinary Medicine, Texas A&M University, College Station, TX, 1985
Peer Reviewed Papers
Torres, S.M., Feeney, D.A., Lekcharoensuk, C., Fletcher, T.F., Clarkson, C.E., Nash, N.L., Hayden, D.W.: Comparison of colloid, thyroid follicular epithelium, and thyroid hormone concentrations in healthy and severely sick dogs. J Am Vet Med Assoc. 222(8):1079-85, 2003.
Rickers, C., Gallegos, R., Seethamraju, R., Wang, X., Swingen, C., Jayaswal, A., Rahrmann, E., Kastenberg, Z., Clarkson, C., Bianco, R., O’Brien, T., Verfaillie, C., Bolman, R., Wilke, N., Jerosch-Herold, M.: Applications of magnetic resonance imaging for cardiac stem Ccll therapy. J Interventional Cardiol 17(1), 2004
Abstracts
Reyes, M., Ross, J.R., Clarkson, C., Bergstrom, R.A., Verfaillie, C.M., Tranquillo, R.T.: Coentrapment of MAPC-derived smooth muscle and endothelial cells for tissue-engineered arteries. American Society of Hematology. 2003
Gallegos, R., Avinash Jayaswal, Christina Clarkson, Eric Rahrmann, Zach Kastenberg, James Xu, Richard Jones, Jenifer Gravelle, Xiaoen Wang, Michael Jerosch-Herold, R. Morton Bolman III, Timothy D. O’Brien, Catherine Verfaillie; Bone Marrow Induced Myocardial Restoration in the Canine Model. American Society of Hematology 2003.
Gallegos, R., X. Wang, A. Jayaswal, E. Rahrmann, R.Jones, Z. Kastenberg, J. Gravelle, X. Xu, C. Clarkson, C. Swingen, R. Seethamraju, N. Osman, Richard Bianco,Timothy D. O'Brien, Catherine M. Verfaillie, R. Morton Bolman, Michael Jerosch-Herold: MRI demonstrates improved regional myocardial strain following stem cell treatment in a canine infarct model. American Heart Association, November 2003
Gallegos, R.P., Cory Swingen, Xiaoen Wang, Christina E. Clarkson, R. Morton Bolman: Serum troponin predicts infarct size. American Heart Association, April 2003
Gallegos, R.P., Avinash Jayaswal, Christina Clarkson, Eric Rahrmann, Zack Kastenberg, Imran Al-Amin Ravi Teja Seethamraju, R. Morton Bolman III, Catherine Verfaillie, Norbert Wilke: Myocardial perfusion reserve to assess cardiac stem cell therapy. North American Society of Cardiac Imaging, September 2002
Research Presentations
Poster: How to Teach an Old Dog a New Trick; Adult Stem Cell Therapy in a Chronic Canine Ischemia Model Assessed by Cardiac MRI, R. Gallegos, A. Jayaswal, C. Clarkson, E. Rahrmann, Z. Kastenberg, X. Wang, I. Al-Amin, R. Seethamraju, N. Wilke, M. Jerosch-Herold, C. Verfaillie, R. Bolman III, University of Minnesota Division of Cardiovascular and Thoracic Surgery, Stem Cell Institute, and Cardiovascular MRI Section and Core Laboratory, Dept. of Radiology..
Poster: Myocardial Perfusion Reserve to Assess Cardiac Stem Cell Therapy. R. Gallegos, A. Jayaswal, C. Clarkson, E. Rahrmann, Z. Kastenberg, I. Al-Amin. R. Seethamraju, R. Bolman III, C. Verfaillie, N. Wilke., NASCI 3rd International Workshop on Coronary MR/CT Angiography. North American Society for Cardiac Imaging, 30th Annual Meeting, September 2002
Current Funding
“Multipotent Stem Cells from Adult Rhesus Macaques,” NIH (NCRR)