Assistant Professor - Veterinary and Biomedical Sciences

e-mail: colli066@umn.edu

Research Interests
Dr. Collister's laboratory studies the long-term control of arterial blood pressure and the pathogenesis of salt dependent hypertension. More specifically, studies investigating the role of hormones acting in the central nervous system to regulate sympathetic nervous system outflow and thus arterial pressure, are the current focus of the laboratory. We use radiotelemetry blood pressure monitoring devices in experimental animals in order to measure blood pressure continuously for weeks to months.

Selected Publications
(For a comprehensive list of  Dr. Collister's recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Collister, J.P., Hornfeldt, B.J., Osborn, J.W., Hypotensive response to losartan in normal rats: role of AngII and the area postrema. Hypertension. 27(part 2): 598-606, 1996.

Collister, J.P., Osborn, J.W., Area postrema lesion attenuates the long-term hypotensive effects of losartan in salt-replete rats. Am. J. Physiol. 274: R357-R366, 1998.

Xu, L., Collister, J.P., Osborn, J.W., Brooks, V.L., Effects of losartan on sympathetic activity and heart rate in sodium deprived rats: role of the area postrema. Am. J. Physiol. 275: R46-R55, 1998.

Collister, J.P., Osborn, J.W., The area postrema does not modulate the long-term salt-sensitivity of arterial pressure. Am. J. Physiol. 275: R1209-R1217, 1998.

Carlson, S., Collister, J.P., Osborn JW. The area postrema modulates hypothalamic Fos responses to intragastric hypertonic saline in conscious rats. Am. J. Physiol. 275: R1921-R1927, 1998.

Osborn, J.W., Collister, J.P., Carlson, S.H., Angiotensin and osmoreceptor in puts to the area postrema: Role in long-term control of fluid homeostasis and arterial pressure. Clin. Exp. Pharm. Physiol. 27: 443-449, 2000.

Collister, J.P., Osborn, J.W., The chronic infusion of hexamethonium and phenylephrine to effectively clamp the sympathetic nervous system. J. Pharm. Toxicol. Methods. 42: 135-147, 2001.

Collister, J.P., Soucheray, S.L., Osborn, J.W., Chronic hypotensive effects of losartan are not dependent on the actions of angiotensin II at AT2 receptors. J. Cardiovasc. Pharm. 39:107-116, 2002.

Collister, J.P., Hendel, M.D., Role of the subfornical organ in the chronic hypotensive response to losartan in normal rats. Hypertension. 41: 576-582, 2003.

Osborn, J.W., Ariza-Nieto, P., Collister, J.P., Soucheray, S., Zimmerman, B., Katz, S., Responsiveness vs. basal activity of plasma ANGII as a determinant of arterial pressure and salt sensitivity. Am. J. Physiol. 285: H2142-H2149, 2003.

Collister, J.P., Hendel, M.D., The role of Ang (1-7) in mediating the chronic hypotensive effects of losartan in normal rats. JRAAS. 4: 176-179, 2003.

Collister J.P., Hendel, M.D., Subfornical organ lesion attenuates chronic hypotensive effects of losartan in salt-replete rats. JRAAS. 4: 207-212, 2003.

Hendel, M. D. and J. P. Collister.   Contribution of the Subfornical Organ to Angiotensin II Induced Hypertension. Am J Physiol Heart Circ Physiol. 288(2): H680-H685, 2005.

Hendel, M. D. and Collister, J. P.,  Sodium balance, arterial pressure and the role of the subfornical organ during chronic changes in dietary salt.  Am J Physiol Heart Circ Physiol. 289(1): H426-H431, 2005.

Collister, J. P. and Hendel, M.D.,  Chronic effects of angiotensin II and AT1 receptor antagonists in subfornical organ lesioned rats.  Clinical and Experimental Pharmacology and Physiology, 32(5-6): 462-466, 2005.

Collister, J. P. and Osborn, J. W.,  The chronic hypotensive effects of losartan and the role of a responsive sympathetic nervous system.  J. Cardiovasc. Pharm. 46(2): 147-154, 2005.

Jacob, F.,  M. D. Hendel, J. P. Collister, J. Armstrong, L. A. Clark, P. Ariza Guzman, W. Engeland, and J. W. Osborn.  Neurally-mediated hypertension in the DOCA-salt model is independent of the subfornical organ.  Brain Res. 1109: 74-82, 2006.

Hendel, M. D. and J. P. Collister.  Role of the renal nerves in chronic angiotensin II induced hypertension. Clinical and Experimental Pharmacology and Physiology. 33: 1225-1230, 2006.

Nahey, D. B. and J. P. Collister.  AngII-induced hypertension and the role of the area postrema during increased dietary salt. Am. J. Physiol. 292(1): H694-H700, 2007.

Ployngam, T. and J. P. Collister.  An intact median preoptic nucleus is necessary for chronic angiotensin II induced hyptertension.  Brain Res. 1162: 69-75, 2007.

Osborn, J. W., J. P. Collister, and P. Guzman.  The effect of peripheral sympathetic nerve dysfunction on salt sensitivity of arterial pressure.  Clinical and Experimental Pharmacology and Physiology, (In Press), 2007.

Nahey, D. B. and J. P. Collister. Changing dietary sodium alters the chronic cardiovascular effects of losartan in rats. JRAAS. (Accepted), 2007.

Current Funding
American Physiological Society's Arthur C. Guyton Award for Excellence in Integrative Physiology, 2003, $15,000.

American Heart Association Pre-Doctoral Fellowship.  “The Role of the Subfornical Organ in Experimental forms of Hypertension.”  01/01/04-12/31/05.  $49,000.  Role:  Mentor.

NIH/NHLBI (RO1).  "Circumventricular organs and cardiovascular regulation."  05/01/04-04/30/08, $882,719.   Role:  Principal Investigator.

NIH/NHLBI.  “Neural Mechanisms of Long Term Cardiovascular Disease.”  08/01/04-07/31/08.  $1,600,000.  Role:  Co-Investigator.

NIH/NHLBI.  “Long-Term Neural Determinants of Cardiovascular Disease.”  12/01/04-11/30/09.  $5,890,000.  Role:  Co-Investigator.

American Medical Systems.  “Subcutaneous Implantation of Coated Surgical Meshes in Rats.”  08/01/05-12/15/05.  $6,709.  Role:  Principal Investigator.

Honors and Awards
Graduate School Fellowship, University of Minnesota. 1994.

Liz Atac Award for Graduate School Excellence and Community Service. 1997.

American Physiological Society Neural Control & Autonomic Regulation Section—Michael J. Brody Young Investigator Award. 1999.

The American Physiological Society Arthur C. Guyton Award for Excellence in Integrative Physiology, 2003.

Current Students
Jessica Meehan,  M.S. student.

Trasida Ployngam, Ph.D. student