B.S., University of Minnesota M.S., Fort Hays State University Ph.D., Texas A&M University Post-Doctoral, University of Rochester, University of Wisconsin—Milwaukee
Research Interests Dr. Reed's laboratory is dedicated to the application of molecular and cytogenetic approaches to the study of genomics and evolution and provides a wide range of research opportunities for students at both the graduate and undergraduate levels. Currently, Dr. Reed's primary research is the application of genomic resources for functional genomic investigations in the turkey. Current projects, funded by USDA, provide a comprehensive approach to investigation of muscle function and development as it relates to meat production. The main objectives of this project are to identify differential expression of muscle genes at three developmental stages (18 day embryo, 1 day post-hatch poult, and 16 wk post-hatch turkey); to study the mechanisms of the identified candidate genes that regulate muscle characteristics during proliferation, differentiation and maturation; to segregate the turkeys based on their meat quality traits and identify differential expression of muscle genes between subgroups; and to genetically map select turkey skeletal muscle genes. A second project is focused on the structure and evolution of the turkey MHC. The main objectives of this project are to sequence the turkey MHC B-locus; identify genomic haplotype markers (SNPs) for this region; and develop and trial assays for genetic testing of commercial and experimental populations. A third project, also funded by USDA is a collaborative effort with Utah State University and involves the genetics of Aflatoxin susceptibility. We are also examining changes in gene expression associated with cardiomyopathy (Round Heart Disease). Other notable projects currently involve llama/alpaca geneics/genomics.
Selected Publications (For a comprehensive list of Dr. Reed's recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Reed KM, Chaves LD and Mendoza KM. 2007. An integrated and comparative genetic map of the turkey genome. Cytogenet Genome Res, in press
Chaves LD, Kreuth SB, and Reed KM. 2007. Characterization of the turkey MHC chromosome through genetic and physical mapping. Special issue on avian genomics in evolution, agriculture and health, Cytogenet Genome Res, 117:213-220.
Lin K, Xu J, Kamara D, Geng T, Kwaku Gyenai K, Reed KM, and Smith EJ. 2007. DNA sequence and haplotype variation in two candidate genes for dilated cardiomyopathy in the turkey, Meleagris gallopavo. Genome, 50:463-469.
Reed KM, Mendoza KM, and Coulombe RA, Jr. 2007. Structure and genetic mapping of the Cytochrome P4501A5 gene in the turkey (Meleagris gallopavo). Cytogenet Genome Res, 116:104-109.
Reed KM, Mendoza KM, Hu GR, Sullivan LR, Grace M, Chaves LD, and Kooyman DL. 2007. Genomic analysis of genetic markers associated with inherited cardiomyopathy (round heart disease) in the turkey (Meleagris gallopavo). Animal Genetics, 38:211-217.
Reed KM, Chaves LD, Hall MK, Knutson TP, Kreuth SB, Ashwell CM, and Burt DW. 2006. Integration of microsatellite-based genetic maps for the turkey (Meleagris gallopavo). Genome, 49: 1308-1318.
Current Funding
“ Identification, differential expression, and mapping of muscle genes in genetically selected turkeys,” NRICGP, USDA.
“Genomics to increase Aflatoxin resistance in turkeys,” NRICGP, USDA.
Current Students
Lee Chaves, PhS. Student, Genetics and Genomics of MHC
Kristelle Mendoza, MS Student, Functional Genomics of Round Heart Disease
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