Selected Publications

Please click here to see all PubMed publications from the Modiano Lab

Tamburini BA, Trapp S, Phang TL, Schappa JT, Hunter L, Modiano JF. (2009). Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed. PLoS ONE, 4(5):e5549. PMID: 19440383. PubMed, Journal Home, PDF

Thomas R, Wang HJ, Tsai P-C, Langford C, Fosmire SP, Jubala CM, Getzy DM, Cutter GR, Modiano JF, Breen M. (2009). Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Res, 17(3):365-377. PMID: 19337847. PubMed

Willoughby Sr JA, Sundar SN, Cheung M, Tin AS, Modiano J, Firestone GL. Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 promoter and inhibiting CDK4 gene expression. J Biol Chem 2009 , in press. (Epub. 2008 Nov 17) PMID: 19017637. PubMed

Jubala CM, Lamerato-Kozicki AR, Borakove M, Lang J, Gardner LA, Coffey D, Helm KM, Schaack J, Baier M, Cutter GR, Bellgrau D, Modiano JF. MHC-dependent desensitization of intrinsic anti-self reactivity. Cancer Immunol Immunother 2009;58(2):171-185. PMID: 18523772. PubMed

Breen M and Modiano JF. (2008) Shared pathogenesis of human and canine tumors - an inextricable link between cancer and evolution (Review). Cancer Therapy, 6, 239-246. Journal, PDF

Modiano JF, Johnson LD, Bellgrau D. Negative regulators in homeostasis of naïve peripheral T cells (Review). Immunol Res 2008;41(2), 137-153. PMID: 18415030. PubMed

Breen M, Modiano JF. Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans--man and his best friend share more than companionship. Chromosome Res 2008;16(1):145-54. PMID: 18293109. PubMed

Fosmire SP, Thomas R, Jubala CM, Wojcieszyn JW, Valli VE, Getzy DM, Smith TL, Gardner LA, Ritt MG, Bell JS, Freeman KP, Greenfield BE, Lana SE, Kisseberth WC, Helfand SC, Cutter GR, Breen M, Modiano JF. Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-cell lymphoma. Vet Pathol 2007 Jul;44(4):467-78. PMID: 17606508. PubMed, PDF

Lin PY, Fosmire SP, Park SH, Park JY, Baksh S, Modiano JF, Weiss RH. Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance. Mol Cancer 2007 Feb 14;6:16.(doi:10.1186/1476-4598-6-16) PMID: 17300726. PubMed, PDF

Modiano JF, Breen M, Valli VE, Wojcieszyn JW, Cutter GR. Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma. Leukemia. 2007 Jan;21(1):184-7. Epub 2006 Sep 21. PMID: 16990767. PubMed, PDF

Khanna C, Lindblad-Toh K, Vail D, London C, Bergman P, Barber L, Breen M, Kitchell B, McNeil E, Modiano JF, Niemi S, Comstock KE, Ostrander E, Westmoreland S, Withrow S. The dog as a cancer model (Correspondence). Nat Biotechnol 2006 Sep;24(9):1065-6. PMID: 16964204. PubMed

Lamerato-Kozicki AR, Helm KM, Jubala CM, Cutter GC, Modiano JF. Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation. Exp Hematol 2006 Jul;34(7):870-8. PMID: 16797414. PubMed, PDF

Modiano JF, Breen M, Lana SE, Ehrhart N, Fosmire SP, Thomas R, Jubala CM, Lamerato-Kozicki AR, Ehrhart EJ, Schaack J, Duke RC, Cutter GR, Bellgrau D. Naturally occurring translational models for development of cancer therapy (Review). Gene Ther Mol Biol, 2006; 10, 31-40. Journal, PDF

Thomas R, Scott A, Langford CF, Fosmire SP, Jubala CM, Lorentzen TD, Hitte C, Karlsson EK, Kirkness E, Ostrander EA, Galibert F, Lindblad-Toh K, Modiano JF, Breen M. Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors. Genome Res 2005 Dec;15(12):1831-7.PMID: 16339382. PubMed

Dickerson EB, Thomas R, Fosmire SP, Lamerato-Kozicki AR, Bianco SR, Wojcieszyn JW, Breen M, Helfand SC, Modiano JF. Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma. Vet Pathol 2005 Sep;42(5):618-32. PMID: 16145208. PubMed, PDF

Jubala CM, Wojcieszyn JW, Valli VE, Getzy DM, Fosmire SP, Coffey D, Bellgrau D, Modiano JF. CD20 expression in normal canine B cells and in canine non-Hodgkin lymphoma. Vet Pathol 2005 Jul;42(4):468-76. PMID: 16006606. PubMed, PDF

Modiano JF, Breen M, Burnett RC, Parker HG, Inusah S, Thomas R, Avery PR, Lindblad-Toh K, Ostrander EA, Cutter GC, Avery AC. Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk. Cancer Res 2005 Jul 1;65(13):5654-61. PMID: 15994938. PubMed, PDF

Frazer-Abel AA, Baksh S, Fosmire SP, Willis D, Pierce AM, Meylemans H, Linthicum DS, Burakoff SJ, Coons T, Bellgrau D, Modiano JF. Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells. J Pharmacol Exp Ther 2004 Nov;311(2):758-69. Epub 2004 Jul 1. PMID: 15231866. PubMed, PDF

Modiano JF, Lamerato-Kozicki AR, Jubala CM, Coffey D, Borakove M, Schaack S, Bellgrau D. Fas ligand gene transfer for cancer therapy (Review). Cancer Ther. 2004; 2(B) 561-70. Journal, PDF

Modiano JF, Sun J, Lang J, Vacano G, Patterson D, Chan D, Franzusoff A, Gianani R, Meech SJ, Duke R, Bellgrau D. Fas ligand-dependent suppression of autoimmunity via recruitment and subsequent termination of activated T cells. Clin Immunol 2004 Jul;112(1):54-65. PMID: 15207782. PubMed, PDF

Fosmire SP, Dickerson EB, Scott AM, Bianco SR, Pettengill MJ, Meylemans H, Padilla M, Frazer-Abel AA, Akhtar N, Getzy DM, Wojcieszyn J, Breen M, Helfand SC, Modiano JF. Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium. Lab Invest 2004 May;84(5):562-72. PMID: 15064773. PubMed, PDF

Bianco SR, Sun J, Fosmire SP, Hance K, Padilla ML, Ritt MG, Getzy DM, Duke RC, Withrow SJ, Lana S, Matthiesen DT, Dow SW, Bellgrau D, Cutter GR, Helfand SC, Modiano JF. Enhancing antimelanoma immune responses through apoptosis. Cancer Gene Ther 2003 Sep;10(9):726-36. PMID: 12944992. PubMed, PDF

Khare S, Banai Y, Gokulan K, Smith R 3rd, Linthicum DS, Modiano JF. Early changes in metabolism of leukemic cell lines upon induction of apoptosis by cytotoxic drugs. Eur J Pharmacol 2003 Mar 28;465(1-2):23-30. PMID: 12650829. PubMed, PDF

Baksh S, Widlund HR, Frazer-Abel AA, Du J, Fosmire S, Fisher DE, DeCaprio JA, Modiano JF, Burakoff SJ. NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell 2002 Nov;10(5):1071-81. PMID: 12453415. PubMed, PDF

Fernandes PJ, Modiano JF, Wojcieszyn J, Thomas JS, Benson PA, Smith R 3rd, Avery AC, Burnett RC, Boone LI, Johnson MC, Pierce KR. Use of the Cell-Dyn 3500 to predict leukemic cell lineage in peripheral blood of dogs and cats. Vet Clin Pathol 2002;31(4):167-82. PMID: 12447779. PubMed, PDF

Koenig A, Bianco SR, Fosmire S, Wojcieszyn J, Modiano JF. Expression and significance of p53, rb, p21/waf-1, p16/ink-4a, and PTEN tumor suppressors in canine melanoma. Vet Pathol 2002 Jul;39(4):458-72. PMID: 12126149. PubMed, PDF

Dickerson EB, Fosmire S, Padilla ML, Modiano JF, Helfand SC. Potential to target dysregulated interleukin-2 receptor expression in canine lymphoid and hematopoietic malignancies as a model for human cancer. J Immunother 2002 Jan-Feb;25(1):36-45. PMID: 11924909. PubMed

Koenig A, Wojcieszyn J, Weeks BR, Modiano JF. Expression of S100a, vimentin, NSE, and melan A/MART-1 in seven canine melanoma cells lines and twenty-nine retrospective cases of canine melanoma. Vet Pathol 2001 Jul;38(4):427-35. PMID: 11467477 PubMed, PDF

Modiano JF, Mayor J, Ball C, Fuentes MK, Linthicum DS. CDK4 expression and activity are required for cytokine responsiveness in T cells. J Immunol 2000 Dec 15;165(12):6693-702. PMID: 11120786 . PubMed, PDF

Ritt MG, Mayor J, Wojcieszyn J, Smith R, Barton CL, Modiano JF. Sustained nuclear localization of p21/WAF-1 upon growth arrest induced by contact inhibition.
Cancer Lett 2000 Sep 29;158(1):73-84. PMID: 10940512 PubMed, PDF

Modiano JF, Mayor J, Ball C, Chitko-McKown CG, Sakata N, Domenico-Hahn J, Lucas JJ, Gelfand EW. Quantitative and qualitative signals determine T-cell cycle entry and progression. Cell Immunol 1999 Oct 10;197(1):19-29. PMID: 10555992. PubMed, PDF

Modiano JF, Ritt MG, Wojcieszyn J, Smith R 3rd. Growth arrest of melanoma cells is differentially regulated by contact inhibition and serum deprivation. DNA Cell Biol 1999 May;18(5):357-67.
PMID: 10360837. PubMed

Chitko-McKown CG, Modiano JF. Clues to immune function and oncogenesis provided by events that activate the cell cycle machinery in normal human T cells. J Leukoc Biol 1997 Oct;62(4):430-7. Review. PMID: 9335311. PubMed

Modiano JF, Amran D, Lack G, Bradley K, Ball C, Domenico J, Gelfand EW. Posttranscriptional regulation of T-cell IL-2 production by human pooled immunoglobin. Clin Immunol Immunopathol 1997 Apr;83(1):77-85. PMID: 9073539. PubMed

Modiano JF, Getzy DM, Akol KG, Van Winkle TJ, Cockerell GL. Retrovirus-like activity in an immunosuppressed dog: pathological and immunological findings. J Comp Pathol 1995 Feb;112(2):165-83. PMID: 7539463. PubMed

Modiano JF, Domenico J, Szepesi A, Lucas JJ, Gelfand EW. Differential requirements for interleukin-2 distinguish the expression and activity of the cyclin-dependent kinases Cdk4 and Cdk2 in human T cells. J Biol Chem 1994 Dec 30;269(52):32972-8. PMID: 7806527. PubMed

Modiano JF, Kokai Y, Weiner DB, Pykett MJ, Nowell PC, Lyttle CR. Progesterone augments proliferation induced by epidermal growth factor in a feline mammary adenocarcinoma cell line. J Cell Biochem 1991 Feb;45(2):196-206. PMID: 2055947. PubMed