B.V.Sc., University of Agricultural Sciences, Bangalore, India (1986)
M.V.Sc, University of Agricultural Sciences, Bangalore, India (1988)
M.P.H., University of Minnesota, Minneapolis, Minnesota (1991)
Ph.D., University of Minnesota, St. Paul, Minnesota (1995)
Dr. Sreevatsan is an Associate Professor of Infectious Disease at the College of Veterinary Medicine, U of M. The principal focus of his laboratory is to define the molecular mechanisms by which bacteria and viruses establish infection. His interests surround several issues in micro-host interactions with specific emphasis on the evolution of the pathogen and it's adaptation to hosts. The translational aspect of these investigations is in the development of improved diagnostic tests and methods for microbial characterization and identification, as well as studies into new generations of antimicrobial vaccines and therapeutics. A second focus in his laboratory is in the improvement of currently available diagnostic tools. As a result some investigations use state-of-the-art molecular methods including the design of novel high affinity ligands and sensitive back-end detection methods. These are coupled with classical and modified extraction protocols to improve recovery of agents of interest for accurate diagnostics. Dr. Sreevatsan is currently investigating the molecular diversity in mycobacteria, microbial population structure and functioning in pathogen induced environments, influenza virus ecology and evolution, and developing high affinity ligands to prion proteins to investigate the pathogenesis and new therapeutic modalities for infectious diseases.
1. Influenza virus ecology and evolution
2. Mycobacterial disease–
a. Host-pathogen interactions – functional genomics of mycobacteria in natural infections; mechanisms of microbial survival and persistence in granuloma; mechanisms of mycobacterial cell entry and exit in ex-vivo (Macrophage, epithelial cell, and co-culture) models.
b. Iron regulation inMycobacterium avium subsp. paratuberculosis(MAP)
c. Role of MAP in Crohn’s disease pathogenesis – animal and cell models
d. Biomarker discovery and applications for mycobacterial infections
e. Population genetic structure of M. bovis
f. Trait-allele association studies in M. bovis
3. Mechanisms of prion misfolding – development high affinity ligands to detect and differentiate prion strains.
4. Metabolic reconstruction and development of improved cultivation media for bioterrorism agents
For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine, and Google Scholar.
Funding – USDA; Johne’s disease integrated program – USDA; Department of Homeland Security; NIH-NIAID – Minnesota Center for Excellence in Influenza Research and Surveillance; Agriculture Experiment Station.
Elise Lamont – PhD Candidate (2011)
Deepti Joshi – PhD Candidate (2012)
Ahmed Abd-allah – PhD Candidate (2012)
Amanda Oliveira – MS student (2011)
Preethi Haran – MS student (2011)
Sri Lab Alumni:
AlifiyaGhadiali – PhD (Ohio State - 2005)
Norma Ramirez – PhD (Ohio State - 2005)
Harish Janagama – MS (Ohio State - 2005); PhD (U of M -2010)
Zhu Xiaochun – MS (U of M - 2008)
Meetu Seth – MS (U of M - 2009)
AbiramiKugadas - MS (U of M - 2010)