Dermatology

Effect of Adipose-Derived Stem and Regenerative Cell Therapy on Atopic Dermatitis

Current Status: New! Active and enrolling
Principal Investigator:  Sheila M. F. Torres, DVM, MS, PhD, DACVD

Contact: 
Marianne Robeck, CVT - phone: 612-624-1352, e-mail robec008@umn.edu
Dr. Torres - phone: 612-624-3746, e-mail torre009@umn.edu

We are seeking dogs with year round allergies for a study investigating the effect of a dog's own stem and regenerative cells on atopic dermatitis.  Dogs must be showing clinical signs, have been skin tested, are 1.5 - 10 years of age, and greater than 18 pounds.  Dogs will need to be withdrawn from any corticosteroids, antihistamines, cyclosporine, and hyposensitization injections (allergy shots).  Once enrolled, dogs will have some fat tissue removed, from which the sponsor, Vet-Stem, will prepare the treatment. 

The study has two parts.  In Part 1, dogs will receive either an intravenous (IV) injection of the prepared treatment, or a placebo injection.  Recheck appointments occur at Day 7, 14 and 28.  At Day 28, we will find out which treatment the dog was on, and proceed to Part 2.

In Part 2 of the study, dogs on placebo will have an injection of the prepared treatment.  Dogs which received the prepared treatment in Part 1 but did not improve enough in scoring, will have an additional injection of the treatment.  No further fat tissue will be needed for these treatments since the sponsor will be banking tissue from Part 1.  Recheck appointments will occur on Day 14, 28, 56, and 84. 

After enrollment, the study covers the costs of the visits, diagnostic tests, adipose extraction, and stem and regenerative cell treatment.  At the end of each part, owners will receive $200 for their participation.

For more information, please contact the names above. 

Genetic Basis of Sebaceous Adenitis in Dogs

Current Status:  Active and enrolling
Principal Investigators: 
Sandra N. Koch, DVM, MS, DACVD
Sheila M. F. Torres, DVM, MS, PhD, DACVD

Contact:
Dr. Koch - phone: 612-626-6212, e-mail nogu0005@umn.edu
Dr. Torres - phone: 612-624-3746, e-mail torre009@umn.edu

This project aims to determine the mode of inheritance of sebaceous adenitis in Havanese dogs. We hope this leads to future studies which will identify the gene(s) associated with canine sebaceous adenitis.   
 

We are looking for Havanese dogs of any age with suspected or diagnosed sebaceous adenitis and Havanese dogs that are 7 years of age or older without sebaceous adenitis.

What is involved:

1. One visit at the Veterinary Medical Center
2. 5 ml blood sample
3. 2-3 6mm skin biopsy samples

The study covers the cost of the visit, blood sample and biopsies. In addition, the study clients will receive $12 for the blood sample and $40.00 for skin biopsy samples as compensation.

To participate or to learn more, please contact Dr. Koch or Dr. Torres (see above).

Efficacy and Field Safety of PF-03394197 Compared to Placebo for the Control of Atopic Dermatitis (AD) in Dogs (study 1)

Continuing Efficacy and Field Safety of PFF-03394197 for the Control of Atopic Dermatitis in Dogs (study 2)

Current Status:  Enrollment closed.
Principal Investigator: 
Sheila M. F. Torres, DVM, MS, PhD, DACVD
Contact:
Marianne Robeck, CVT: robec008@umn.edu or 612-624-1352

Dr. Sheila Torres, a board-certified dermatologist, is conducting a canine atopic dermatitis study.  This is a double-blinded study where each dog will receive either the oral investigational veterinary product (IVP) or a placebo for 4 weeks.   Following the 4 weeks, enrolled dogs may have the option of having the IVP for an additional 12 weeks.  

Therapeutic Targets for Atopic Dermatitis

Current Status:  Active
Principal Investigators: 
Sheila M. F. Torres, DVM, MS, PhD, DACVD
Douglas A. Plager, PhD (Mayo Clinic)
Sandra N. Koch, DVM, MS
Contact:
Dr. Torres - phone: 612-624-3746, e-mail torre009@umn.edu

This project is part of the Minnesota Partnership for Biotechnology and Medical Genomics. The long term goal is to establish canine atopic dermatitis as a model of human atopic dermatitis in order to better understand the disease and develop treatments to help both dogs and humans.