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  Home > Current Clinical Trials > Oncology



Welcome to the Oncology Clinical Trials Page!

The following studies are currently recruiting patients.

Click on the study name for full information below:

Downregulation of Protein Kinase CK2 as Targeted Therapy for Feline Oral Squamous Cell Carcinoma  

To find out how to donate samples for veterinary oncology research, see Modiano Lab Study Info.

Downregulation of Protein Kinase CK2 as Targeted Therapy for Feline Oral Squamous Cell Carcinoma 

Current Status: Active and enrolling
Principal Investigator: Antonella Borgatti, DVM, DACVIM
Dr. Borgatti:
Amber Winter, study technician: 612-624-1352 or
Oncology service at 612-626-8387 (main VMC number) 

Feline oral squamous cell carcinoma (FOSCC) is one of the most common cancers seen in cats and it significantly impairs these cats' quality of life. This study will use gene therapy against a target that is commonly impaired in cancer, and is given in a new delivery agent (nanocapsule). The study is looking at the safety and efficacy of the new therapy in a standard dose escalation trial.

Cats eligible for the study:

  • Cats with oral squamous cell carcinoma restricted to the oral cavity and regional lymph nodes only
  • Measurable disease (>1 cm)
  • No distant metastases present based upon abdominal ultrasound and chest radiographs
  • No severe systemic disease based upon exam, bloodwork including thyroid (TT4), and urinalysis

Study procedures and schedule:

  • Initial screening (see eligible list above)
  • Day 1 biopsy of tumor and normal oral tissue
  • Monday/Thursday or Tuesday/Friday schedule of treatment, each time dosing with nanocapsules given intravenously (IV). Blood and urine tests once per week. This schedule continues for 3 weeks.
  • Final visit with biopsy, blood and urine testing

This study covers the costs of the nanocapsules injections and study procedures above (value of $2200 - $2500). The client will be responsible for the initial screening (approx. $600 - $950). 

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For more information on cancer research at the College of Veterinary Medicine, please go to the Animal Cancer Care and Research site.

For information on the Oncology department at the Veterinary Medical Center, go here.

You may also Contact Us at the CIC.



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