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  Home > Current Clinical Trials > Small Animal Medicine
 

Small Animal Medicine

CVM Mickelson Westie 2

Welcome to the Small Animal Medicine Studies Page!

If you would like more information about a study, or think you would like to enroll your pet, contact the person listed under the study. You may also Contact Us at the CIC.

   

Clinical Features and Genetic Basis of Pulmonary Fibrosis in Dogs

Current Status:  Active and enrolling.
Principal Investigator: Ned Patterson, DVM, PhD
Contact: Amber Winter, CVT, 612-624-1352 E-mail: alwinter@umn.edu

In that past 15 years, a form of Pulmonary (lung) Fibrosis (scarring) has been recognized in some dogs, almost exclusively in West Highland white terriers (WHWT). We do not know currently what causes this or what genetics might contribute to it. A genetic predisposition in WHWT is suspected because only this breed has been reported to have confirmed pulmonary fibrosis (PF). We also do not have a known specific treatment to offer and therapy at best is to relieve the symptoms but does not affect disease progression.

We are looking for blood samples from WHWT with PF and healthy WHWT dogs over 8 years old, and chest x-rays on WHWT with low blood oxygen (determined from the blood sample). The blood samples will be used for DNA so we can compare affected dogs with unaffected dogs to see if we can detect gene mutations. We hope to identify gene mutations that might predispose dogs to PF. If these are found and verified, they could be used as a test to diagnose PF in the future and as a help in breeding decisions to help decrease the number of WHWT with PF. 

Some of the dogs with low blood oxygen in this study will have the opportunity of a CT scan which will help in full diagnosis of possible PF.

Benefits to the owner: no charge for study procedures and free physical exam. If your dog has low blood oxygen, X-rays will help in further diagnosis. Some dogs will recieve a CT at no charge. No other compensation is available, however, you will be contributing to discoveries that could help diagnose and eventually treat PF in dogs, and possibly people.

To participate, please contact Amber Winter above.

 
Genetic basis of calcium oxalate stones in high-risk breeds

Current Status:  Active and enrolling.
Principal Investigator: Ned Patterson, DVM, PhD
Contact: Dr. Eva Furrow  E-mail: furro004@umn.edu

We are looking for certain breeds of dogs to help determine the genetic basis for developing calcium oxalate urinary stones. Your dog may be eligible if he/she:

  • is a purebred Miniature Schnauzer, Bichon Frise, Shih Tzu, Yorkshire Terrier  or Miniature Poodle
  • has a history of calcium oxalate stones (Case group) OR
  • is at least 8 years old and has never had calcium oxalate stones (Control group)
  • is not currently receiving any steroid medications (ex. prednisone, dexamethasone, methylprednisone) or diuretics (ex. Lasix, hydrochlorothiazide)
  • has never been diagnosed with Cushing's Disease 

We will perform free blood work (mini kidney and electrolyte panel) and urine tests for all dogs and abdominal x-rays for Control group dogs (with no history of stones).  We will also compensate owners $25 per dog for participation in the study.

The study requires one visit to the VMC for these non-invasive tests and collection of a small sample of DNA.

If you are interested in the study, please contact Dr. Furrow at 612-625-6222 or furro004@umn.edu.

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For more information on our Small Animal Medicine Department, please click here .

 

 



 

 

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