Current Comparative and Molecular Biosciences Students
A-F | G-L | M-R | S-Z
Clayton, Jonathan B.
B.S., Biology, and B.A., Religion and Philosophy, Barton College, 2008
Certificate in Primatology, Duke University, 2008
Dr. Tim Johnson & Dr. Michael Murtaugh
Maintenance of red-shanked doucs and other colobines as captive populations has been largely unsuccessful due to an inadequate understanding of their nutritional requirements. They are highly susceptible to gastric disorders when maintained on commercially prepared diets in captivity. Improving their diet in captivity is limited due to critical gaps in our understanding of local fibrous vegetation and the enteric microbial adaptations that facilitate toxicant neutralization and efficient extraction of key nutrients. My research will address the douc diet related to their specialized digestive capacity and their gut microbiota.
Clayton, J. B. & Glander, K. E. 2011. Dietary Choices by Four Captive Slender Lorises (Loris tardigradus) When Presented With Various Insect Life Stages. Zoo Biology 30:189-198.
Clayton J. B., Johnson, T. J., and Trent, A. M. 2011. Examination of Escherichia coli populations in a captive zoological collection of nonhuman primates. Am J Physical Anthropology, 144(S52):110.
Clayton J. B., Kim, H. B., Glander, K. E., Isaacson, R. E., and Johnson, T. J. 2012. Fecal Bacterial Diversity of the Wild Mantled Howling Monkey (Alouatta palliata). Am J Physical Anthropol, 147(S54):116-117.
Clayton J. B., Johnson, T. J., and Trent, A. M. Examination of Campylobacter and Escherichia coli populations in a captive zoological collection of nonhuman primates. 42nd Annual American Association of Zoo Veterinarians (AAZV) Conference. Oral presentation. South Padre Island, Texas. October 2010.
Clayton J. B., Johnson, T. J., and Trent, A. M. Examination of Escherichia coli populations in a captive zoological collection of nonhuman primates. Morris Animal Foundation Wildlife Conference. Poster session. New Orleans, Louisiana. March 2011.
Clayton, J. B., Kim, H. B., Glander, K. E., Isaacson, R. E., and Johnson, T. J. Fecal Bacterial Diversity of the Wild Mantled Howling Monkey (Alouatta palliata). 81st Annual Meeting of the American Association of Physical Anthropologists (AAPA). Poster session. Portland, Oregon. April 2012.
Margot Marsh Biodiversity Foundation Research Grant
NIH PharmacoNeuroImmunology Pre-doctoral Fellowship, 2013- present
Merial-NIH Summer Scholars Grant. 2010.
Morris Animal Foundation Veterinary Student Scholars Grant. 2010.
American Association of Physical Anthropologists William S. Pollitzer Student Travel Award. 2012.
M.S., Preventive Veterinary MedJilin University, China 2012
D.V.M., Jilin University, China 2009
Dr. Bruce Blazar
My research focuses on the prevention and therapy of chronic Graft Versus Host Disease (cGVHD), a serious complication of hematopoietic stem cell transplantation. Lung fibrosis is one of the manifestations of cGVHD and is associated with very high morbidity and mortality. My project seeks to stop the pathogenic process of lung fibrosis caused by cGVHD. Using a cGVHD model that was created by our lab, we are able to evaluate the efficacy of the treatment by both pulmonary functional test as well as histopathology evaluation.
D.V.M., Iowa State University, 2006
B.S., Animal Science, Iowa State University, 2002
Dr. Cathy Carlson
My research efforts have been investigating basic mechanisms of neuropathic and visceral pain utilizing rodent models. Specific projects have focused on (1) the involvement of the bioactive derived peptides of neurosecretory VGF (nonacronymic) in models of neuropathic pain in rats and mice, (2) the impact of the intestinal microflora on neuro-immune-epithelial interactions and promotion of visceral pain in mice, and (3) the differential morphological distribution of adeno-associated virus mediated gene transfer to sensory neurons in mouse dorsal root ganglia.
NIH Comparative Medicine Training Fellowship
Office of Graduate Programs Travel Award, Fall 2013
V.M.D., University of Pennsylvania, 2007
B.A., Harvard, 2003
Dr. Ned Patterson
Calcium oxalate uroliths are a common and significant problem in both the canine and human populations. Hypercalciuria (increased urinary calcium) is often the driving force behind stone formation, and the high heritability of this trait suggests a genetic component in both species. My project involves acquiring DNA samples and evaluating urinary calcium and oxalate levels in several canine breeds with increased risk for calcium oxalate stones. For this, I am conducting a genome-wide association study in the Miniature Schnauzer, and will also correlate urinary measurements with stone-forming risk in multiple breeds.
Furrow E, Minor K, Taylor S, Mickelson JR, and Patterson EE. Relationship between Dynamin 1 Mutation Status and Phenotype in 109 Labrador Retrievers with Recurrent Collapse During Exercise. J Am Vet Med Assoc 2013;242:786-91.
Furrow E, Armstrong PJ, and Patterson EE. High prevalence of the c.74A>C SPINK1 variant in Miniature and Standard Schnauzers. J Vet Intern Med 2012;26:1295-9.
Furrow E, Groman RP. Intranasal infusion of clotrimazole for the treatment of nasal aspergillosis in two cats. J Am Vet Med Assoc 2009;15:1188-93.
Furrow E. The Critical Care of Aflatoxin-Induced Liver Failure. Veterinary Medicine Oct, 2007;644-651.
Ahn AN, Furrow E, Biewener AA. Walking and running in the red-legged running frog, Kassina maculata. J Exp Biol 2004;207:399-410.
Furrow E, Mickelson JM, Lulich JP, Armstrong PJ, Minor KM, and Patterson EE. Genome-wide association study of calcium oxalate urolithiasis in the Miniature Schnauzer. Oral presentation delivered at the 7th the international conference on Advances in Canine and Feline Genomics and Inherited Diseases, Cambridge, MA, 2013.
Furrow E, Lulich JP, Mickelson JM, Armstrong PJ, and Patterson EE. Genetics of calcium oxalate urolithiasis in a spontaneous canine model. Oral presentation delivered at the ROCK society annual meeting, Indianapolis, IN, 2012.
Furrow E, Lulich JP, Mickelson JM, Armstrong PJ, and Patterson EE. Parallel mapping of calcium oxalate urolithiasis and diabetes mellitus in the Miniature Schnauzer. Poster presentation delivered at 6th the international conference on Advances in Canine and Feline Genomics and Inherited Diseases, Visby, Sweden, 2012.
Furrow E, Minor K, Taylor S, Mickelson JR, and Patterson EE. Atypical Collapse in Exercising Labrador Retrievers Unaffected by the Dynamin-1 Mutation. Oral presentation delivered at the ACVIM forum, Anaheim, CA, 2010.
Furrow E, Scherer SS, Wong SB, Massicotte C. How Does Vincristine Cause Neuropathy in Normal and Mutant Mice. Oral presentation delivered at the University of Pennsylvania, School of Veterinary Medicine Phi Zeta Day, Philadelphia, PA, 2005.
Ahn AN, Furrow E, Biewener AA. Walking and running in the red-legged running frog, Kassina maculata. Oral presentation delivered at the annual meeting of the Society of Integrative and Comparative Biology, Toronto, Canada, 2003.
AKC Clinician Scientist Fellowship 2013 - 2014
Advances in Canine and Feline Genomics and Inherited Diseases Student Award for Abstract Excellence Sept 2013
NIH Comparative Medicine and Pathology Training Fellowship
Joanne Schmidt O’Brien/Bee Hanlon Research Fellow, 2010 - 2011
ACVIM distinguished resident research award, 2010
Greggs III, Willie
D.V.M., Veterinary Medicine, Tuskegee University, 2008
B.S., Biological Sciences, Clemson University, 2004
Dr. Louis Mansky
Greggs WM 3rd, Clouser CL, Patterson SE, Mansky LM. Discovery of drugs that possess activity against feline leukemia virus. J Gen Virol. 2012 Apr;93(Pt 4):900-5.
Greggs WM 3rd, Clouser CL, Patterson SE, Mansky LM. Broadening the use of antiretroviral therapy: the case for feline leukemia virus. Ther Clin Risk Manag. 2011;7:115-22.
Greggs III, Willie. 2003. “Invasive Species: The Evolutionary Impact of Invasive Species.”
Greggs III, Willie. 2004. “Preexisting Sensory Bias to Orange in Poecillia petenensis and P. mexicana.”
Greggs III, Willie. 2008. “Triple Threat!: Canine Blastomycosis, Histoplasmosis, and Aspergillosis.”
Greggs III, Willie; Maurer, John; et. al. 2006. “Are Certain Salmonella Serovars in Poultry More Pathogenic for Humans than Others?”
Hanlon/Schmidt/O'Brien Fellow, 2011-2012
B.S., Human Biology, UW-Green Bay, 2007
Drs. Becky Davies and Michael Murtaugh
Investigation of the use of c-peptide measurements to monitor porcine islet xenotransplantation procedures in conjunction with the Schultze Diabetes Institute.
RL Hegstad-Davies, SF Torres, LC Sharkey, SC Gresch, PR Davies, CA Muñoz-Zanzi; Breed–specific reference intervals for assessing thyroid function in seven dog breeds. 2010 Points of Pride Research Days, CVM, University of Minnesota, St. Paul.
D.V.M., China Agricultural University, 2011
Dr. Paul Bohjanen
I am interested in understanding the mechanism of how CELF protein family modulates mRNA decay during T cell activation and T cells malignancy.
D.V.M., China Agricultural University, 2012
Dr. Carol Cardona & Dr. Michael Murtaugh
The lakes and wetlands of Minnesota are home to many wild birds. Ducks make up the largest group of waterfowl in Minnesota with 22 species nesting or visiting in various seasons. Ducks are one of the critical natural hosts of influenza A viruses (IAV). Annually, more than 20 subtypes of IAV are isolated from Minnesota ducks. Minnesota is also home to a very large turkey population. Turkeys are uniquely susceptible to certain types of IAVs. My research interest focuses on understanding the complex forces driving the emergence of IAV from the natural reservoir into the domestic animal hosts with the use of both classical and cutting edge virological and bioinformatic tools, to help scientific, public, animal health and policy communities improve animal and human health.
B.S., Microbiology, University of Minnesota, 2006
Dr. Tim Johnson
My research focuses the molecular mechanisms underlying the spread of antibiotic resistance genes. Often, bacterial pathogens acquire many different resistance genes in a single event. This is achieved by large pieces of mobile DNA termed plasmids. Specifically, I study the regulation of plasmid transfer. Microbes must balance opportunity with adversity during plasmid transfer because generating the necessary gene products is costly. Plasmids have evolved a variety of regulatory mechanisms that respond to microbial or environmental cues to maximize the efficiency of plasmid spread. The plasmid system that I study utilizes a novel regulatory network. By understanding this system we can gain insight into bacterial gene regulation and the driving forces behind the dissemination of antibiotic resistance.
Timothy J. Johnson and Kevin S. Lang. Inc.A/C plasmids: An emerging threat to human and animal health? 2012. Mobile Genetic Elements. 2:2159-2543.
Kevin S. Lang, Jessica L. Danzeisen, Wayne Xu, and Timothy J. Johnson. Transcriptome mapping of pAR060302, a blaCMY-2 positive IncA/C plasmid. In review. Appl Environmental Microbiol 78:3379,2012.
Kevin S. Lang, J. M. Anderson, S. Schwarz, L. Williamson, J. Handelsman, and R. S. Singer. 2010. Novel Florfenicol and Chloramphenicol Resistance Gene Discovered in Alaskan Soil by Using Functional Metagenomics. Appl. Environ. Microbiol. 76:5321-5326.
Muñoz-Aguayo J., K. S. Lang, T. M. LaPara, G. Gonzalez, and R. S. Singer. 2007. Evaluating the Effects of Chlortetracycline on the Proliferation of Antibiotic-Resistant Bacteria in a Simulated River Water Ecosystem. Appl. Environ. Microbiol. 73:5421-5425.
Kevin S. Lang. Dissecting the regulation of IncA/C conjugation. Oral presentation. Comparative and Molecular Biosciences Student Seminar. St. Paul, MN. September, 2013.
Kevin S. Lang and Jonathon B. Clayton. Determining the ecological impacts of dioxin contamination using endangered primates as sentinel species. Dow Chemical Sustainability Innovation Student Challenge oral presentation competition. Hosted by the Institute on the Environment, University of Minnesota. November 2012.
Kevin S. Lang. Role and mechanism of an IncA/C plasmid encoded putative regulatory protein. Oral presentation. Comparative and Molecular Biosciences Student Seminar. St. Paul, MN. October, 2012.
Kevin S. Lang. Regulatory proteins encoded on IncA/C plasmids. Oral presentation. Comparative and Molecular Biosciences Student Seminar. St. Paul, MN. April, 2012.
Kevin S. Lang, Jessica L. Danzeisen, Portia Holtegaard, and Timothy J. Johnson. Genetic factors involved in the persistence and dissemination of blaCMY-2 IncA/C plasmids. Oral presentation. Conference for Research Workers in Animal Disease (CRWAD). December 2011.
Kevin S. Lang Jessica L. Danzeisen, and Timothy J. Johnson. Transcriptome mapping of pAR060302, a blaCMY-2 positive IncA/C plasmid. CVM Points of Pride Research Days Poster Session. 2011.
Kevin S. Lang and Randall S. Singer. Quantifying Factors Associated with Changes in Antibiotic Susceptibility Patterns of Enterococci Isolated from Dairy Cattle. 18th European Congress of Clinical Microbiology and Infectious Disease. Poster session. Barcelona, Spain. April 2008.
USDA AFRI NIFA Fellowship, 2013-2015
Dr. Vaughn Larson Student Leadership Award, 2013
University of Minnesota Doctoral Dissertation Fellowship 2013-2014
UMN CVM Graduate Student Professional Travel Grant, 2013
Dow Sustainability Innovation Student Challenge Award Finalist, 2012
Microbial and Plant Genomics Institute Travel Award, 2011
ECCMID Travel Award, 2008
M.S., Preventive Veterinary Medicine, Chinese Academy of Agricultural Science, 2013
D.V.M., Agricultural University of Hebei, 2010
Dr. Michael Murtaugh
D.V.M., Northwest A & F University, China, 2011
Dr. Dan Kaufman
My research interest is focusing on the differentiation of human stem cells to both better understand basic mechanisms of human development, as well as to derive potentially novel therapeutic cell populations. I use human pluripotent stem cells, including both human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) to study the development of lymphocyte populations. This study can provide exciting and innovative strategies to better understand human development biology and produce new therapies.
M.S./Residency, Equine Surgery, Colorado State University, 2010
LA Medicine and Surgery Internship, University of Minnesota, 2007
D.V.M., Michigan State University, 2006
B.S., Animal Science, Michigan State University, 2002
Dr. Molly McCue and Dr. Troy Trumble
Osteochondrosis is a developmental disease of the cartilage that affects young horses across breeds. The focus of my research is using genome-wide association studies and next-generation sequencing technologies to identify chromosomal regions, and eventually specific gene variations, that are associated with increased risk of osteochondrosis in the horse, using yearling Standardbreds as a model population.
McCoy AM, R Schaefer, JL Petersen, PL Morrell, MA Slamka, JR Mickelson, SJ Valberg, ME McCue. 2013. Evidence of positive selection for a glycogen synthase (GYS1) mutation in domestic horse populations. J Hered (accepted for publication).
McCoy AM, McCue ME. 2013. Validation of imputation between equine genotyping arrays. Anim Genet (in press).
McCoy AM, F Toth, NI Dolvik, S Ekman, J Ellemann, K Olstad, B Ytrehus, C Carlson. Articular osteochondrosis: a comparison of naturally-occurring human and animal disease. Osteoarthritis Cart 2013 Aug 15. pii: S1063-4584(13)00914-X. doi: 10.1016/j.joca.2013.08.011. [Epub ahead of print].
Annette M. McCoy, Eileen S. Hackett, Robert J. Callan, Barbara E. Powers. 2009. Alimentaryassociated carcinomas in Vietnamese pot-bellied pigs: 5 cases (2000-2008). J Am Vet Med Assoc 235:1336-1341.
McCoy, AM, LR Goodrich. 2011. Use of a radiofrequency probe for tenoscopic-guided annular ligament desmotomy. Equine Vet J DOI: 10.1111/j.2042-3306.2011.00454.x.
McCoy AM, ES Hackett, AE Wagner, KR Mama, DA Hendrickson. 2011. Pulmonary gas exchange and plasma lactate in horses with gastrointestinal disease undergoing emergency exploratory laparotomy: a comparison with an elective surgery patient population. Vet Surg 40:601-609.
McCoy AM, ME McCue. Validation of an imputation pipeline for equine genotyping data. (10th Dorothy Russell Havemeyer Foundation International Equine Genome Mapping Workshop, Furnas, Azores, Portugal, July 2013).
McCoy AM, JL Petersen, JR Mickelson, RJ Piercy, CM Isgren, S Lykkjen, ME McCue. Identification of modifying loci associated with pacing in Standardbreds. (10th Dorothy Russell Havemeyer Foundation International Equine Genome Mapping Workshop, Furnas, Azores, Portugal, July 2013 [poster]).
McCoy, Annette M., Eileen S. Hackett, Ann E. Wagner, Khursheed R. Mama, Dean A. Hendrickson. Characterization of Oxygenation in Equine Colic Patients Undergoing Emergency Exploratory Celiotomy. (ACVS Veterinary Symposium, Washington D.C., October 2009)
McCoy, Annette M., Elysia Schaefer, Erin Malone. How to Perform Effective Blocks of the Equine Ear. (AAEP 53rd Annual Convention, Orlando, FL, December 2007)
McCoy AM, JL Petersen, MA Slamka, PL Morrell, JR Mickelson, SJ Valberg, ME McCue. 2011. Evidence of positive selection for the GYS1 mutation in equine Polysaccharide Storage Myopathy (Plant and Animal Genome XVIII Conference, San Diego, CA, January 2011 [poster])
McCoy AM, LR Goodrich. Use of a radiofrequency probe for tenoscopic-guided annular ligament desmotomy. (ACVS Veterinary Symposium, Seattle, WA, October 2010)
Doctoral Dissertation Fellowship, 2013-2014
NIH Comparative Medicine and Pathology Training Grant
Vaughn Larson Award, 2012
American Association of Equine Practitioners Past Presidents' Research Fellow Award, 2011
ACVS Resident’s Forum, 2nd place, Large Animal Clinical Research Presentations, 2010
B.S. Biology, Hamline University, 2009
Dr. Kent Reed
My research uses gene expression, at both the individual gene and genome wide level, to investigate immune responses in the turkey. I am currently using RNA-sequencing to determine expression changes across the spleen transcriptome after exposure to aflatoxin B1, a highly hepatotoxic and immunosuppressive feed contaminant. I am also using an in ovo aflatoxin exposure model to investigate differences in expression and susceptibility in wild and domestic turkeys. Transcriptome analysis will provide insight into the extreme sensitivity of domestic turkeys and provide potential targets to improve poultry resistance to this toxin.
Monson MS, Mendoza KM, Reed, KM. in press. Expression Profiles for Genes in the Turkey MHC B-Locus. Poultry Science.
Reed KM, Bauer MM, Monson MS, Benoit B, Chaves LD, O'Hare TH, Delany ME. 2011. Defining the turkey MHC: identification of expressed class I- and class IIB-like genes independent of the MHC-B. Immunogenetics. 63(11):753-71.
Reed KM, Bauer MM, Monson MS, Chaves LD. 2011. The turkey MHC: Sequence, haplotype structure, and gene expression. In: Turkey Production and Health: An Update. Proceedings 6th International Meeting of the Working Group 10 (Turkey) of WPSA (Ed. Hafez, H. M.):36-52. Berlin, Germany: Mensch & Buch Verlag.
Monson MS, Mendoza KM, Settlage RE, Reed KM. Initial assembly and analysis of the MHC B-locus of the ocellated turkey. Plant and Animal Genomes Conference XXI. San Diego, CA. January 12-16, 2013.
Monson MS, Settlage RE, Mendoza KM, Rawal S, Coulombe RA, Dalloul RA, Reed KM. Utilizing spleen transcriptome analysis to identify responses to aflatoxin B1 in the domestic turkey. 33rd Conference of the International Society of Animal Genetics. Cairns, AUS. July 15-20, 2012.
Monson MS, Settlage RE, Mendoza KM, Rawal S, Coulombe RA, Reed KM. Spleen Transcriptome Response to Aflatoxin in the Domestic Turkey. Plant and Animal Genomes Conference XX. San Diego, CA. January 14-18, 2012.
Monson MS, Mendoza KM, Velleman SG, Reed KM. Expression of MHC B-Locus Genes in Commercial Turkeys: Examination of Immune and Non-Immune Tissues. Plant and Animal Genomes Conference XIX. San Diego, CA. January 15-19, 2011.
Ben Pomeroy Avian Health Award, 2012-2013
Travel Bursary Award, International Society of Animal Genetics Conference 2012.
Neal A. Jorgenson Genome Travel Grant, Plant and Animal Genome XX, 2012
Ben Pomeroy Avian Health Award, 2011-2012.
M.S., Biomedical Sciences, Auburn University, 2013
D.V.M., Colorado State University, 2009
B.S., Arizona State University Tempe, 2005
Dr. Michael Murtaugh
NIH Comparative Medicine and Pathology Training Fellowship, 2013-2016
D.V.M., Iowa State University, 2013
M.P.H., University of Iowa, 2013
B.S., Biology, Iowa State University, 2009
Dr. Michael Murtaugh
NIH Comparative Medicine and Pathology Training Fellowship, 2013-2016
M.V.Sc., University of Melbourne, Australia, 2009
B.V.Sc.(Hons), University of Queensland, Australia, 2001
Dr. Michael Murtaugh
My current research investigates genetic and biologic features of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and their interaction with the porcine host immune system. The major aim for my thesis is to characterize a novel viral protein (ORF5a) of PRRSV. Investigation of the functional significance of ORF5a is important to further understand the fundamental biology of PRRSV. This will enable greater insight to the molecular mechanisms of viral pathogenesis and host-pathogen interactions in order to ultimately design more effective vaccines or treatment strategies to PRRSV.
Nicotine-mediated signals modulate cell death and survival of T lymphocytes. Oloris SC, Frazer-Abel AA, Jubala CM, Fosmire SP, Helm KM, Robinson SR, Korpela DM, Duckett MM, Baksh S, Modiano JF. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):299-309.
Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma. Tamburini BA, Phang TL, Fosmire SP, Scott MC, Trapp SC, Duckett MM, Robinson SR, Slansky JE, Sharkey LC, Cutter GR, Wojcieszyn JW, Bellgrau D, Gemmill RM, Hunter LE, Modiano JF. BMC Cancer. 2010 Nov 9;10:619.
Poster presentations at The University of Minnesota College of Veterinary Medicine Points of Pride Research Day (September 2010): Unexpected suppressive effect of IL-8 on proliferation of canine hemangiosarcoma cells. Robinson SR, Scott MC, Dickerson EB, Sharkey LC, Modiano JF.
Science Museum of Minnesota, Cancer and the Human Body, interactive display ‘Canines and Cancer’ Robinson SR, Cannon C. February 27 2010.
Best American College of Veterinary Microbiologists Presentation, 2011 Conference of Research Workers in Animal Diseases
Office of Graduate Programs Travel Award, Fall 2013
B.A., History, University of Minnesota, 2009
Dr. Maxim Cheeran
Elucidating the role of CDB T cells on the impairment of adult neurogenesis following infection by herpes simplex and subsequent encephalitis.
Strandberg KL, Rotschafer JH, Vetter SM, Buonpane RA, Kranz DM, Schlievert PM. Staphylococcal superantigens cause lethal pulmonary disease in rabbits. J Infect Dis. 2010 Dec 1;202(11):1690-7.
Assimacopoulos AP, Strandberg KL, Rotschafer JH, Schlievert PM. Extreme pyrexia and rapid death due to Staphylococcus aureus infection: analysis of 2 cases. Clin Infect Dis. 2009 Mar 1;48(5):612-4.
Michael B. Oldstone Young Investigator Award, International Society for NeuroVirology, 2013
D.V.M., Purdue University, 2003
Drs. Molly McCue and Jim Mickelson
My research interests include studying the molecular basis of equine genetic disease and genomic influences on non-inherited disease. The focus of my research is identification of genetic susceptibility loci associated with equine metabolic syndrome. For more information about the equine metabolic syndrome research project please visit: www.cvm.umn.edu/equinegenetics/EMS.
Anderson SM , Rendahl AK , Gustafson-Seabury A , Kachroo P , Chowdhary BP , Schultz NE, Valberg SJ , Mickelson JR , and McCue ME. Skeletal Muscle Gene Expression In Horses With Type 1 Polysaccharide Storage Myopathy. Poster presented at Plant and Animal Genome Conference, San Diego, CA (January 2010)
Schultz NE, Valberg SJ, and Lucio M. Assessment of Intramyofiber Lipid Content in Horses. Poster presented at ACVIM Forum, Anaheim, CA (June 2010)
Pfizer Morris Animal Foundation Research Fellow
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B.S., Genetics, Cell Biology & Development, University of Minnesota, 2007
Dr. Sabita Roy
My research examines the mechanisms which underlie the increase of circulating LPS levels within HIV+ patients who abuse opiates as compared with nonusers. LPS is thought to be integral to HIV disease progression to AIDS by causing constitutive inflammation and an activated immune system systemically. To understand this effect, we are focusing on a mouse model of HIV that utilizes the HIV-1 Tat protein, which has been observed to alter epithelial permeability on its own. In combination with Tat, we will examine whether morphine enhances gut permeability, and delve into the mechanism by examining epithelial cells both in vitro and within guts of mice, as well as by examining changes in immune cell phenotype and function.
L. J. Mauro, S. J. Wenzel, and G. M. Sindberg. Regulation of chick bone growth by leptin and catecholamines. Poult. Sci., April 1, 2010; 89(4): 697 - 708.
Sindberg, GM; Meng, J; Molitor, TW; Roy, S. Morphine and HIV-1 Tat as comorbidities additively reduce gut barrier function. Annual meeting of the Society on Neuroimmune Pharmacology, 2012.
Sindberg, GM; Lindborg, B; Bansal-Pakala, P; O’Brien, T. Comparison of in vitro immunomodulatory effects of rhesus bone marrow-derived MSC and MAPC, and dermal fibroblasts. Annual meeting of the American Association of Immunologists, 2011.
Sindberg, GM; Pahuja, A; Bansal-Pakala, P. Effects of exenatide on lymphocyte proliferation and survival in vivo for potential use in conjunction with T regulatory cell infusion for β islet cell transplantation. Surgery Research Day (University of Minnesota), 2010.
Sindberg, GM; O’Brien, E; Beitz, A; Mauro, LJ. Osteoblast-tumor interactions modulate TGFalpha-mediated regulation of MCP-1. Annual meeting of the American Association for Cancer Research, 2009.
Office of Graduate Programs Enhanced Learning Travel Award, 2013
NIH PharmacoNeuroImmunology Fellowship: 2011 to current
Vaughn Larson Scholarship: 2011
M.S., Cell, Molecular, and Organismal Biology, Saint Cloud State University, 2008
B.S., Biology, University of Wisconsin-Stevens Point, 1997
Dr. Al Beitz
My research focus is to delineate the effects of sex steroid hormones in pain. Specifically, I evaluate the effects of estrogen on pain sensitivity and nociceptor expression in the dorsal root ganglion (DRG) neurons of male and female C3H mice with hind paw bone cancer. The cell bodies of primary afferent fibers that innervate bone and bone tumors are located in DRG. Our results show modulating 17ß-estradiol causes a change in transient receptor potential vanilloid-1 (TRPV1) expression in DRG neurons and is associated with a change in fibrosarcoma-induced mechanical allodynia in both male and female mice. These results demonstrate that sex hormones play a role in tumor-induced nociception.
Triemstra JL, Beitz AJ. 2012. 17ß-estradiol Modifies TRPV1 Expression in DRG Neurons. 31st Annual Scientific Meeting of the American Pain Society. Honolulu, HI
Triemstra JL, Beitz AJ. 2010. The Role of Sex and DRG Neurons in Cancer Pain. 14th Annual Scientific Meeting of the Society of Behavioral Neuroendocrinology. Toronto, ON.
Triemstra JL, Beitz AJ. 2010. The Role of Sex and DRG Neurons in Cancer Pain. 4th Annual Scientific Meeting of the Organization for the Study of Sex Differences. Ann Arbor, MI.
Student Travel Award: 2012 American Pain Society 31st Annual Meeting, Honolulu HI.
Student Travel Award: 2012 Short Course: Pain Mechanisms-From Molecules to Treatment, Karolinska Institute, Stockholm, Sweden.
NIH NRSA 5T32DA007097-30, PharmacoNeuroImmunology Pre-Doctoral Fellowship: 2009-2012.
Nominated by University of Minnesota to attend the 61st Meeting of Nobel Laureates. 2010.
M.S., Preventive Veterinary Medicine, China Institute of Veterinary Drug Control, 2013
D.V.M., Sichuan Agricultural Institute, 2010
Dr. Michael Murtaugh
D.V.M., Jilin University, China, 2011
Dr. Michael Murtaugh
My current research focus is evolution of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and selection mechanisms at the cellular and animal levels. The results are expected to provide basic insights into the effects of vaccination and intentional infection on evolution of viral virulence.
D.V.M., Louisiana State University, 2002
Dr. Randy Singer
Wolf TM, Wünschmann A, Morningstar-Shaw B, Pantlin GC, Rasmussen JM, Thompson RL. An outbreak of Salmonella enterica serotype Choleraesuis in goitered gazelle (Gazella subgutrosa subgutrosa) and a Malayan tapir (Tapirus indicus). J Zoo Wildl Med. 2011 Dec;42(4):694-9.
Wolf TM, Gandolf AR, Dooley JL, Atkinson MW, Wolfe BA. Serologic response to West Nile virus vaccination in the greater one-horned rhinoceros (Rhinoceros unicornis). J Zoo Wildl Med. 2008 Dec;39(4):537-41.
Wolf TM, Mitchell MA, Roy A, Tully T, Mauer K, Cooper LA. Seroprevalence of Alphaviruses in chelonians from southeastern Louisiana. Journal of Herpetelogical Medicine and Surgery 2008, 18(1): 5-8.
Wünschmann A, Armien A, Harris NB, Brown-Elliott BA, Wallace RJ, Rasmussen J, Willette M, Wolf T. Disseminated panniculitis in a Bottlenose dolphin (Tursiops truncatus) due to Mycobacterium chelonae infection. Journal of Zoo and Wildlife Medicine 2008, 39(3): 412-420.
Gandolf AR, Wolf TM, Radcliffe RW. Serial chemical restraint for treatment of decubitus ulcers in two neonatal white rhinoceroses (Ceratotherium simum). J Zoo Wildl Med. 2006 Sep;37(3):387-92.
Weiss RB, TM Wolf, AP Pessier, J Greathouse, and BA Wolfe. Health assessments of Eastern hellbender (Cryptobranchus alleganiensis alleganiensis) populations in Ohio and West Virginia. American Association of Zoo Veterinarians Conference, Tulsa, OK, October 25-28, 2009.
Rasmussen JM, Miller, A, Wunschmann A, Holman PJ, Wolf TM. Babesiosis in a captive herd of musk oxen (Ovibos moschatus): Treatment and a novel approach for prevention. American Association of Zoo Veterinarians Conference, Los Angeles, CA, October 10-17, 2008.
Dykstra J, Wolf T, Windels S, Sullivan M, Wunschmann A. Fatal Francisella tularensis Type B infection and seroprevalence of F. tularensis antibodies in free-ranging beavers (Castor Canadensis). American Association of Zoo Veterinarians Conference, Los Angeles, CA, October 10-17, 2008.
Pfizer/Morris Animal Foundation PhD Fellowship, 2010-2014
D.V.M., China Agricultural University, 2011