Course Title: Comparative Models of Disease
Course Descriptor: CMB 8303; 2 credits
Schedule: Alternating Spring semesters, T, Th 1:00-2:00 pm
Enrollment: Limit of 12
Prerequisites: Enrollment in a M.S. or Ph.D. degree program or consent of instructor
Course Coordinator: John Collister, D.V.M./Ph.D.
Comparative medicine is the interdisciplinary field that seeks to identify the similarities and differences in disease between species and to utilize such comparisons to understand pathophysiology and improve the health of humans and animals. Comparative studies are fundamental to essentially every biologic discipline yet expertise in animal disease is uncommon. The course will be structured to cover a number of different disease processes in a variety of organ systems using examples of animal models. The first lecture in each area will serve to provide an overview of the clinical relevance of the problem/disease and/or present animal models used to study the disease process or problem. The subsequent class period will focus on a research manuscript that utilizes one or more animal models relevant to the area/discipline. Students will present the paper to the group at this second session.
Statement of Objectives:
The goal of this course is to provide a broad overview of issues relevant to comparative biomedical research and the appropriate application of such studies. Students will learn to evaluate the advantages and disadvantages for primary animal model systems for major diseases. This includes:
1) principles of animal experimentation
2) appreciation of species differences in physiology, anatomy, and immune systems
3) use of naturally occurring vs artificial or created animal models
4) current needs for appropriate and informative animal models.
Course Assignments and Evaluation Procedures:
Attendance - 10%.
Presentation of one research paper - 30%.
Weekly 1 page summary/evaluation of presented research paper - 30%.
Final oral presentation of a designated animal model/disease - 30%.
Grading: >90% = A; 80-89% = B; 70-79% = C; 60-69% = D; < 60 = F
"Biological Aspects of Disease: Contributions from Animal Models" Iannaccone (Editor)
Review articles and research manuscripts provided by instructors.