Animal models of disease

Researchers

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Al Beitz

Work in the area of pain and analgesia focusing on inflammatory psin and cancer pain. Examining mechanisms of chronic pain and mechanisms of acupuncture's effects on pain, inflammattion and cancer growth.

 

 

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Cathy S. Carlson

 Morphological and MRI studies of osteoarthritis and osteochondrosis.

 

 

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James E. Collins

Anatomic pathology as it relates to infectious diseases, agriculture, public health and biomedical research

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Gerard Cramer

My research program focuses on providing evidence based therapeutic and preventative solutions for dairy cow lameness.

 

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Maxim Cheeran

Our research lab is focused on understanding the role of host responses in the pathogenesis of viral infections, with a substantial effort devoted to investigating the impact of neuroinflammation on CNS viral disease and in promoting recovery from brain damage. We use a mouse model of herpes encephalitis to study the impact of specific immune components of the virus-induced inflammation cascade on neurogenesis in the adult brain. We also investigate immune responses to viral infections in farm animals, most notably swine. Using these animal models, we study mechanisms of disease and emergence of novel viruses like swine influenza virus and porcine epidemic diarrhea virus (PEDv).

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John Collister

Our lab studies the central neuro hormonal regulation of long term arterial pressure and the mechanisms in hypertension and sympathoexcitation during heart failure.

 

 

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Michael Conzemius

 

 

 

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Erin Dickerson

The Dickerson laboratory focuses on mechanisms of drug resistance, identifying drug targets, and new therapeutic approaches. In addition, we are focusing on how metabolic changes affect these processes.

 

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Connie Gebhart

Main focus is diagnostic bacteriology and development/evaluation of diagnostic tests. Research involves enteric diseases of animals caused by bacteria, especially Lawsonia, Brachyspira, and Campylobacter species.

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 David Halvorson

 

 

 

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Dick Isaacson

 My laboratory is studying the molecular basis of pathogenesis of two pathogens: Escherichia coli and Salmonella enterica serovar Typhimurium. A common theme in each project is the identification of unique genes required for pathogenesis, understanding the functions of those genes, and determining the mechanisms controlling their expression.

 

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Alice Larson

Our focus is on pain, especially musculoskeletal pain, and depression. We're interested in the role stress hormones, mast cells and TRPV1 receptors play in these two areas.

 

 

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Yuying Liang

My research interests are focused on the virus-host interactions in the replication and pathogenesis of two RNA viral pathogens, arenaviruses and influenza virus, with an ultimate goal of developing novel antiviral therapeutics.

 

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Jody Lulich

Calcium oxalate urinary stones represent a painful, debilitating, and costly disease that affects humans and dogs. Our long-term research goals are to understand key factors responsible for calcium oxalate stone disease and develop safe and effective therapies to prevent stone recurrence. In addition to clinial nutritional studies we investigating genetic markers of disease and investigating the microanatomy of uroliths.

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 Hinh Ly

We have recently developed an infectious molecular clone for a prototypic BSL2 arenavirus (i.e., Pichinde virus - PICV) as well as a safe and convenient mini-replicon system for the human Lassa fever virus (LASV). We have also developed a safe and useful small animal model for Lassa fever by infecting guinea pigs with PICV. Using these systems, we are interested in characterizing a novel functional mechanism of the Lassa viral nucleoprotein in mediating host innate immune suppression (Qi, et al., 2010, Nature, 468: 779-783) as well as to investigate in details the processes of viral genome replication/transcription and virulence.

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Molly McCue

Our research focuses on the genetic basis and functional analysis of naturally occurring neuromuscular and metabolic disease in horses. Our work includes both diseases that are both clinically and economically important in the horse, as well as the use of the horse as a biomedical model.

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Jim Mickelson

I am a major contributor to the international equine genome mapping effort and study the molecular and genetic basis of metabolic, neuromuscular and musculoskeletal disease in dogs and horses. I also collaborate on the identification of genomic signatures of selection for performance traits and the functional underlying alleles in the horse.

 

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Jaime Modiano

Genetics/molecular biology of cancer - understanding heritable risk traits for common canine tumors Cancer immunology/immunotherapy - understanding mechanisms of immune response to cancer in lab, in clinic, back to lab. Current work specifically studying tumor immunosuppressive barrier Lymphocyte activation - intrinsic negative regulation and its role in maintaining lymphocyte quiescence Cancer pathology/diagnostic medicine - stratification of molecular tumor subtypes that are clinically relevant (prognostic and to guide therapy) Pre-clinical (lab animals and spontaneous tumors of dogs) drug development studies for cancer therapeutics (drugs and biologics). Development of FasL gene-based immunotherapy, ligand targeted toxins, antibodies, genetically modified bacterial vectors, targeted nanoparticles carrying gene therapy, small molecules Nicotine immunotoxicology - role of nicotine in lymphocyte activation and in tumro progression

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Julie Olson

My research area is neuroimmunology. My lab uses a mouse model to study multiple sclerosis and pain in humans. The mouse model is a virus-induced disease and we study the immune response that leads to demyelinating disease and treatments to reduce and/or prevent disease.

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Ned Patterson

My primary research currently is in epilepsy, genetics, metabolic disease, neurologic disorders, molecular medicine, neuromodulation, electrophysiology, and comparative medicine. Much of the research is in naturally occurring canine models for the sake of dogs and as translational for human research including epilepsy, neuropathies, and calcium oxalate urolithasis.

 

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Liz Pluhar

I am currently running 3 clinical trials in dogs with brain tumors looking at novel therapies that may translate to human medicine. I also am developing a new model of a chronic critical size defect in goat tibias also to be used the large animal model used to test and compare novel bone regenerative therapies for translation into human orthopedic disease. I am also using a swine model to test treatment of traumatic brain injury and a sheep model of osteoporosis to examine the effects of PTH.

 

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Srirama Rao

The focus of research in our laboratory is to understand the cellular and molecular mechanisms that lead to allergic diseases -including food allergies and asthma. This reserach involves collaboration with basic, applied and clinical researchers and has translational application for both human and animal health.

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Davis Seelig

Our laboratory studies the pathogenic mechanisms in the deer-origin prion disease, Chronic Wasting Disease (CWD), including: 1) mechanisms of neuronal pathology, 2) pathways of prion intestinal invasion, and 3) elucidation of the linkage between the accumulation of misfolded prion protein and the clinical symptoms of CWD. Additionally, our laboratory is seeking to refine the diagnosis and characterization of lymphoproliferative disease in the dog.

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Leslie Sharkey

I perform clinical research focused on developing and optimizing diagnostic testing in companion animal species, primarily dogs and cats. My clinical research focuses on complications of chemo and radiation therapy in laboratory animal models, predominantly effects on heart, blood, and bone. Recently, I am collaborating on some human studies that branch off from the laboratory animal.

 

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Pam Skinner

My research program is working to gain understanding of disease pathogenesis and to develop novel therapeutic approaches for HIV and Prion diseases.

 

 

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Srinand Sreevatsan

I am interested in ecology, evolution, and epidemiology of infectious agents. My group uses a combination of epidemiological, evolutionary, and molecular tools to address - pathogen-host interactions, population genetic structure of microbes, and investigations on molecular mechanisms host adaptation, enhanced transmissibility and virulence.

 

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Troy Trumble

Dr. Trumble in collaboration with Dr. Murray Brown at the University of Florida, established the Collaborative and Comparative Orthopedic Biomarker Research lab that focuses on the use of direct and indirect biomarkers of osteoarthritis in horses. The goal of this collaborative effort is to be able to use biomarkers to diagnose osteoarthritis in its early stages when treatment may have an effect and possibly prevent further progression in both horses and humans.

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Lucy Vuchanova

 My primary area of research is pain mechanisms. We also have ongoing projects on neuro-immune interactions in skin and intestinal mucosa.

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Zheng Xing

I have been studying host responses and the underlying basic mechanism in animals and humans infected with avian influenza viruses. We are recently also exploring the emerging novel bunyaviruses that may be present in agricultural animals and pose a threat to animal and human health.

 

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  • Last modified on January 27, 2014