Anatomic pathology as it relates to infectious diseases, agriculture, public health and biomedical research
Hematopoietic stem and progenitor cells (HSPCs) primarily reside in the bone marrow and give rise to all blood cells. HSPCs can exit the bone marrow and enter sites of inflammation. I study the role of these cells outside of the bone marrow in a model of cutaneous Staphylococcus aureus infection. The ultimate goal is to use endogenous HSPCs for improving outcome in patients with infectious disease.
Genetics/molecular biology of cancer - understanding heritable risk traits for common canine tumors Cancer immunology/immunotherapy - understanding mechanisms of immune response to cancer in lab, in clinic, back to lab. Current work specifically studying tumor immunosuppressive barrier Lymphocyte activation - intrinsic negative regulation and its role in maintaining lymphocyte quiescence Cancer pathology/diagnostic medicine - stratification of molecular tumor subtypes that are clinically relevant (prognostic and to guide therapy) Pre-clinical (lab animals and spontaneous tumors of dogs) drug development studies for cancer therapeutics (drugs and biologics). Development of FasL gene-based immunotherapy, ligand targeted toxins, antibodies, genetically modified bacterial vectors, targeted nanoparticles carrying gene therapy, small molecules Nicotine immunotoxicology - role of nicotine in lymphocyte activation and in tumro progression
Our laboratory studies the pathogenic mechanisms in the deer-origin prion disease, Chronic Wasting Disease (CWD), including: 1) mechanisms of neuronal pathology, 2) pathways of prion intestinal invasion, and 3) elucidation of the linkage between the accumulation of misfolded prion protein and the clinical symptoms of CWD. Additionally, our laboratory is seeking to refine the diagnosis and characterization of lymphoproliferative disease in the dog.
I perform clinical research focused on developing and optimizing diagnostic testing in companion animal species, primarily dogs and cats. My clinical research focuses on complications of chemo and radiation therapy in laboratory animal models, predominantly effects on heart, blood, and bone. Recently, I am collaborating on some human studies that branch off from the laboratory animal.
My research program is working to gain understanding of disease pathogenesis and to develop novel therapeutic approaches for HIV and Prion diseases.