My primary and active research areas involve diseases and injuries that occur at the human-animal interface. These often reflect new and emerging issues (i.e. C. difficile, MRSA) or evolving disciplines such as veterinary infection prevention in the clinic/hospital setting.
Investigating the mechanisms by which neuroimmune signaling processes influence the interactions of microorganisms with mucosal epithelial cells located on internal body surfaces susceptible to infection.
Morphological and MRI studies of osteoarthritis and osteochondrosis.
Our lab studies the central neuro hormonal regulation of long term arterial pressure and the mechanisms in hypertension and sympathoexcitation during heart failure
The Dickerson laboratory focuses on mechanisms of drug resistance, identifying drug targets, and new therapeutic approaches. In addition, we are focusing on how metabolic changes affect these processes.
Dr. Goyal's research interests include diagnosis, pathogenesis and control of viral infections in livestock and poultry and the development of methods for the detection and prevention of human and animal viruses in food, water and environment.
Research to support public policy-making in the areas of animal health, food safety and public health. Using risk analysis tools to support decision-making for preparedness and response. One Health competencies and leadership
My laboratory is studying the molecular basis of pathogenesis of two pathogens: Escherichia coli and Salmonella enterica serovar Typhimurium. A common theme in each project is the identification of unique genes required for pathogenesis, understanding the functions of those genes, and determining the mechanisms controlling their expression.
Food systems in a global food security context including food sufficiency, food safety, food defense and food system resiliency. Current efforts include food system interdependencies with other critical infrastructures and baseline measurements of food security in developing countries.
Our focus is on pain, especially musculoskeletal pain, and depression. We're interested in the role stress hormones, mast cells and TRPV1 receptors play in these two areas.
My research interests are focused on the virus-host interactions in the replication and pathogenesis of two RNA viral pathogens, arenaviruses and influenza virus, with an ultimate goal of developing novel antiviral therapeutics
Genetics/molecular biology of cancer - understanding heritable risk traits for common canine tumors Cancer immunology/immunotherapy - understanding mechanisms of immune response to cancer in lab, in clinic, back to lab. Current work specifically studying tumor immunosuppressive barrier Lymphocyte activation - intrinsic negative regulation and its role in maintaining lymphocyte quiescence Cancer pathology/diagnostic medicine - stratification of molecular tumor subtypes that are clinically relevant (prognostic and to guide therapy) Pre-clinical (lab animals and spontaneous tumors of dogs) drug development studies for cancer therapeutics (drugs and biologics). Development of FasL gene-based immunotherapy, ligand targeted toxins, antibodies, genetically modified bacterial vectors, targeted nanoparticles carrying gene therapy, small molecules Nicotine immunotoxicology - role of nicotine in lymphocyte activation and in tumro progression
My research area is neuroimmunology. My lab uses a mouse model to study multiple sclerosis and pain in humans. The mouse model is a virus-induced disease and we study the immune response that leads to demyelinating disease and treatments to reduce and/or prevent disease.
I am currently running three clinical trials in dogs with brain tumors looking at novel therapies that may translate to human medicine. I also am developing a new model of a chronic critical size defect in goat tibias also to be used the large animal model used to test and compare novel bone regenerative therapies for translation into human orthopedic disease. I am also using a swine model to test treatment of traumatic brain injury and a sheep model of osteoporosis to examine the effects of PTH.
I perform clinical research focused on developing and optimizing diagnostic testing in companion animal species, primarily dogs and cats. My clinical research focuses on complications of chemo and radiation therapy in laboratory animal models, predominantly effects on heart, blood, and bone. Recently, I am collaborating on some human studies that banch off from the laboratory animal.
I seek to identify cost-effective and efficacious interventions for reducing foodborne pathogen contamination of meat and for minimizing the development and spread of antibiotic resistance in bacteria.
My research program is working to gain understanding of disease pathogenesis and to develop novel therapeutic approaches for HIV and Prion diseases.
I am interested in ecology, evolution, and epidemiology of infectious agents. My group uses a combination of epidemiological, evolutionary, and molecular tools to address - pathogen-host interactions, population genetic structure of microbes, and investigations on molecular mechanisms host adaptation, enhanced transmissibility and virulence.
I am currently involved with ecosystem health studies, largely infectious diseases, that seek to understand the ecology of infectious diseases and the interconnectedness between animal and human hosts.
Dr. Trumble in collaboration with Dr. Murray Brown at the University of Florida, established the Collaborative and Comparative Orthopedic Biomarker Research lab that focuses on the use of direct and indirect biomarkers of osteoarthritis in horses. The goal of this collaborative effort is to be able to use biomarkers to diagnose osteoarthritis in its early stages when treatment may have an effect and possibly prevent further progression in both horses and humans.
Main research interests are in immunogenetics and inflammation. Current active research projects are as follows: 1) Human IgG Fc receptor function in sarcoidosis; 2) Genetic mechanisms of human nutrophil antigen systems in transfusion medicine; and 3) Genetics of human chronic inflammatory diseases.
I have been studying host responses and the underlying basic mechanism in animals and humans infected with avian influenza viruses. We are recently also exploring the emerging novel bunyaviruses that may be present in agricultural animals and pose a threat to animal and human health