Immunity and inflammation
Work in the area of pain and analgesia focusing on inflammatory psin and cancer pain. Examining mechanisms of chronic pain and mechanisms of acupuncture's effects on pain, inflammattion and cancer growth.
Investigating the mechanisms by which neuroimmune signaling processes influence the interactions of microorganisms with mucosal epithelial cells located on internal body surfaces susceptible to infection.
My laboratory is focused on understanding factors (genetics, metabolic state, nutrition, management, behavior) associated with immune function and health of periparturient dairy cows. Furthermore, in my laboratory we explore reproductive strategies to improve fertility of cows.
Our research lab is focused on understanding the role of host responses in the pathogenesis of viral infections, with a substantial effort devoted to investigating the impact of neuroinflammation on CNS viral disease and in promoting recovery from brain damage. We use a mouse model of herpes encephalitis to study the impact of specific immune components of the virus-induced inflammation cascade on neurogenesis in the adult brain. We also investigate immune responses to viral infections in farm animals, most notably swine. Using these animal models, we study mechanisms of disease and emergence of novel viruses like swine influenza virus and porcine epidemic diarrhea virus (PEDv).
Our lab studies the central neuro hormonal regulation of long term arterial pressure and the mechanisms in hypertension and sympathoexcitation during heart failure
Main focus is diagnostic bacteriology and development/evaluation of diagnostic tests. Research involves enteric diseases of animals caused by bacteria, especially Lawsonia, Brachyspira, and Campylobacter species.
Applied research in dairy population medicine. Areas of emphasis currently include calf health management, mastitis, metabolic disease and Johne's disease.
Hematopoietic stem and progenitor cells (HSPCs) primarily reside in the bone marrow and give rise to all blood cells. HSPCs can exit the bone marrow and enter sites of inflammation. I study the role of these cells outside of the bone marrow in a model of cutaneous Staphylococcus aureus infection. The ultimate goal is to use endogenous HSPCs for improving outcome in patients with infectious disease.
Our focus is on pain, especially musculoskeletal pain, and depression. We're interested in the role stress hormones, mast cells and TRPV1 receptors play in these two areas.
My research interests are focused on the virus-host interactions in the replication and pathogenesis of two RNA viral pathogens, arenaviruses and influenza virus, with an ultimate goal of developing novel antiviral therapeutics.
Genetics/molecular biology of cancer - understanding heritable risk traits for common canine tumors Cancer immunology/immunotherapy - understanding mechanisms of immune response to cancer in lab, in clinic, back to lab. Current work specifically studying tumor immunosuppressive barrier Lymphocyte activation - intrinsic negative regulation and its role in maintaining lymphocyte quiescence Cancer pathology/diagnostic medicine - stratification of molecular tumor subtypes that are clinically relevant (prognostic and to guide therapy) Pre-clinical (lab animals and spontaneous tumors of dogs) drug development studies for cancer therapeutics (drugs and biologics). Development of FasL gene-based immunotherapy, ligand targeted toxins, antibodies, genetically modified bacterial vectors, targeted nanoparticles carrying gene therapy, small molecules Nicotine immunotoxicology - role of nicotine in lymphocyte activation and in tumro progression
Molecular mechanisms of infectious disease resistance in swine using relevant viral infection models.
My research area is neuroimmunology. My lab uses a mouse model to study multiple sclerosis and pain in humans. The mouse model is a virus-induced disease and we study the immune response that leads to demyelinating disease and treatments to reduce and/or prevent disease.
I have been transitioning from a primary focus on reproductive physiology in wildlife to more of a focus on emerging challenges at the intersection of livestock, humans, wildlife and the environment
I am currently running 3 clinical trials in dogs with brain tumors looking at novel therapies that may translate to human medicine. I also am developing a new model of a chronic critical size defect in goat tibias also to be used the large animal model used to test and compare novel bone regenerative therapies for translation into human orthopedic disease. I am also using a swine model to test treatment of traumatic brain injury and a sheep model of osteoporosis to examine the effects of PTH.
The focus of research in our laboratory is to understand the cellular and molecular mechanisms that lead to allergic diseases -including food allergies and asthma. This reserach involves collaboration with basic, applied and clinical researchers and has translational application for both human and animal health.
My research is dedicated to the application of molecular and cytogenetic approaches to the study of genomics, immunogenetics and evolution.
My research program is working to gain understanding of disease pathogenesis and to develop novel therapeutic approaches for HIV and Prion diseases.
My primary area of research is pain mechanisms. We also have ongoing projects on neuro-immune interactions in skin and intestinal mucosa.
Main research interests are in immunogenetics and inflammation. Current active research projects are as follows: 1) Human IgG Fc receptor function in sarcoidosis; 2) Genetic mechanisms of human nutrophil antigen systems in transfusion medicine; and 3) Genetics of human chronic inflammatory diseases.
I have been studying host responses and the underlying basic mechanism in animals and humans infected with avian influenza viruses. We are recently also exploring the emerging novel bunyaviruses that may be present in agricultural animals and pose a threat to animal and human health