Laboratory Animals/Rabbits/Mice/Rats/Guinea Pigs/Hamsters
Work in the area of pain and analgesia focusing on inflammatory psin and cancer pain. Examining mechanisms of chronic pain and mechanisms of acupuncture's effects on pain, inflammattion and cancer growth.
Morphological and MRI studies of osteoarthritis and osteochondrosis.
Our research lab is focused on understanding the role of host responses in the pathogenesis of viral infections, with a substantial effort devoted to investigating the impact of neuroinflammation on CNS viral disease and in promoting recovery from brain damage. We use a mouse model of herpes encephalitis to study the impact of specific immune components of the virus-induced inflammation cascade on neurogenesis in the adult brain. We also investigate immune responses to viral infections in farm animals, most notably swine. Using these animal models, we study mechanisms of disease and emergence of novel viruses like swine influenza virus and porcine epidemic diarrhea virus (PEDv).
Anatomic pathology as it relates to infectious diseases, agriculture, public health and biomedical research.
Our lab studies the central neuro hormonal regulation of long term arterial pressure and the mechanisms in hypertension and sympathoexcitation during heart failure.
Main focus is diagnostic bacteriology and development/evaluation of diagnostic tests. Research involves enteric diseases of animals caused by bacteria, especially Lawsonia, Brachyspira, and Campylobacter species.
Hematopoietic stem and progenitor cells (HSPCs) primarily reside in the bone marrow and give rise to all blood cells. HSPCs can exit the bone marrow and enter sites of inflammation. I study the role of these cells outside of the bone marrow in a model of cutaneous Staphylococcus aureus infection. The ultimate goal is to use endogenous HSPCs for improving outcome in patients with infectious disease.
Our focus is on pain, especially musculoskeletal pain, and depression. We're interested in the role stress hormones, mast cells and TRPV1 receptors play in these two areas.
My research interests are focused on the virus-host interactions in the replication and pathogenesis of two RNA viral pathogens, arenaviruses and influenza virus, with an ultimate goal of developing novel antiviral therapeutics.
We have recently developed an infectious molecular clone for a prototypic BSL2 arenavirus (i.e., Pichinde virus - PICV) as well as a safe and convenient mini-replicon system for the human Lassa fever virus (LASV). We have also developed a safe and useful small animal model for Lassa fever by infecting guinea pigs with PICV. Using these systems, we are interested in characterizing a novel functional mechanism of the Lassa viral nucleoprotein in mediating host innate immune suppression (Qi, et al., 2010, Nature, 468: 779-783) as well as to investigate in details the processes of viral genome replication/transcription and virulence.
Genetics/molecular biology of cancer - understanding heritable risk traits for common canine tumors Cancer immunology/immunotherapy - understanding mechanisms of immune response to cancer in lab, in clinic, back to lab. Current work specifically studying tumor immunosuppressive barrier Lymphocyte activation - intrinsic negative regulation and its role in maintaining lymphocyte quiescence Cancer pathology/diagnostic medicine - stratification of molecular tumor subtypes that are clinically relevant (prognostic and to guide therapy) Pre-clinical (lab animals and spontaneous tumors of dogs) drug development studies for cancer therapeutics (drugs and biologics). Development of FasL gene-based immunotherapy, ligand targeted toxins, antibodies, genetically modified bacterial vectors, targeted nanoparticles carrying gene therapy, small molecules Nicotine immunotoxicology - role of nicotine in lymphocyte activation and in tumro progression
My research area is neuroimmunology. My lab uses a mouse model to study multiple sclerosis and pain in humans. The mouse model is a virus-induced disease and we study the immune response that leads to demyelinating disease and treatments to reduce and/or prevent disease.
The focus of research in our laboratory is to understand the cellular and molecular mechanisms that lead to allergic diseases -including food allergies and asthma. This reserach involves collaboration with basic, applied and clinical researchers and has translational application for both human and animal health.
I perform clinical research focused on developing and optimizing diagnostic testing in companion animal species, primarily dogs and cats. My clinical research focuses on complications of chemo and radiation therapy in laboratory animal models, predominantly effects on heart, blood, and bone. Recently, I am collaborating on some human studies that branch off from the laboratory animal.
Our laboratory studies the pathogenic mechanisms in the deer-origin prion disease, Chronic Wasting Disease (CWD), including: 1) mechanisms of neuronal pathology, 2) pathways of prion intestinal invasion, and 3) elucidation of the linkage between the accumulation of misfolded prion protein and the clinical symptoms of CWD. Additionally, our laboratory is seeking to refine the diagnosis and characterization of lymphoproliferative disease in the dog.
My research program is working to gain understanding of disease pathogenesis and to develop novel therapeutic approaches for HIV and Prion diseases.
My primary area of research is pain mechanisms. We also have ongoing projects on neuro-immune interactions in skin and intestinal mucosa.