My laboratory is focused on understanding factors (genetics, metabolic state, nutrition, management, behavior) associated with immune function and health of periparturient dairy cows. Furthermore, in my laboratory we explore reproductive strategies to improve fertility of cows.
My research program focuses on providing evidence based therapeutic and preventative solutions for dairy cow lameness.
The Dickerson laboratory focuses on mechanisms of drug resistance, identifying drug targets, and new therapeutic approaches. In addition, we are focusing on how metabolic changes affect these processes.
Calcium oxalate urinary stones represent a painful, debilitating, and costly disease that affects humans and dogs. Our long-term research goals are to understand key factors responsible for calcium oxalate stone disease and develop safe and effective therapies to prevent stone recurrence. In addition to clinial nutritional studies we investigating genetic markers of disease and investigating the microanatomy of uroliths.
Our research focuses on the genetic basis and functional analysis of naturally occurring neuromuscular and metabolic disease in horses. Our work includes both diseases that are both clinically and economically important in the horse, as well as the use of the horse as a biomedical model.
I am a major contributor to the international equine genome mapping effort and study the molecular and genetic basis of metabolic, neuromuscular and musculoskeletal disease in dogs and horses. I also collaborate on the identification of genomic signatures of selection for performance traits and the functional underlying alleles in the horse.
Genetics/molecular biology of cancer - understanding heritable risk traits for common canine tumors Cancer immunology/immunotherapy - understanding mechanisms of immune response to cancer in lab, in clinic, back to lab. Current work specifically studying tumor immunosuppressive barrier Lymphocyte activation - intrinsic negative regulation and its role in maintaining lymphocyte quiescence Cancer pathology/diagnostic medicine - stratification of molecular tumor subtypes that are clinically relevant (prognostic and to guide therapy) Pre-clinical (lab animals and spontaneous tumors of dogs) drug development studies for cancer therapeutics (drugs and biologics). Development of FasL gene-based immunotherapy, ligand targeted toxins, antibodies, genetically modified bacterial vectors, targeted nanoparticles carrying gene therapy, small molecules Nicotine immunotoxicology - role of nicotine in lymphocyte activation and in tumor progression
My research area is neuroimmunology. My lab uses a mouse model to study multiple sclerosis and pain in humans. The mouse model is a virus-induced disease and we study the immune response that leads to demyelinating disease and treatments to reduce and/or prevent disease.
My primary research currently is in epilepsy, genetics, metabolic disease, neurologic disorders, molecular medicine, neuromodulation, electrophysiology, and comparative medicine. Much of the research is in naturally occurring canine models for the sake of dogs and as translational for human research including epilepsy, neuropathies, and calcium oxalate urolithasis.
I am currently running 3 clinical trials in dogs with brain tumors looking at novel therapies that may translate to human medicine. I also am developing a new model of a chronic critical size defect in goat tibias also to be used the large animal model used to test and compare novel bone regenerative therapies for translation into human orthopedic disease. I am also using a swine model to test treatment of traumatic brain injury and a sheep model of osteoporosis to examine the effects of PTH.
I perform clinical research focused on developing and optimizing diagnostic testing in companion animal species, primarily dogs and cats. My clinical research focuses on complications of chemo and radiation therapy in laboratory animal models, predominantly effects on heart, blood, and bone. Recently, I am collaborating on some human studies that branch off from the laboratory animal.
Dr. Trumble in collaboration with Dr. Murray Brown at the University of Florida, established the Collaborative and Comparative Orthopedic Biomarker Research lab that focuses on the use of direct and indirect biomarkers of osteoarthritis in horses. The goal of this collaborative effort is to be able to use biomarkers to diagnose osteoarthritis in its early stages when treatment may have an effect and possibly prevent further progression in both horses and humans.
The genetic and nutritional basis for equine neurologic and muscle disorders including Shivers, rhabdomyolysis and other myopathies.