Work in the area of pain and analgesia focusing on inflammatory psin and cancer pain. Examining mechanisms of chronic pain and mechanisms of acupuncture's effects on pain, inflammation and cancer growth.
Our research lab is focused on understanding the role of host responses in the pathogenesis of viral infections, with a substantial effort devoted to investigating the impact of neuroinflammation on CNS viral disease and in promoting recovery from brain damage. We use a mouse model of herpes encephalitis to study the impact of specific immune components of the virus-induced inflammation cascade on neurogenesis in the adult brain. We also investigate immune responses to viral infections in farm animals, most notably swine. Using these animal models, we study mechanisms of disease and emergence of novel viruses like swine influenza virus and porcine epidemic diarrhea virus (PEDv).
Anatomic pathology as it relates to infectious diseases, agriculture, public health and biomedical research
Our focus is on pain, especially musculoskeletal pain, and depression. We're interested in the role stress hormones, mast cells and TRPV1 receptors play in these two areas.
Our research focuses on the genetic basis and functional analysis of naturally occurring neuromuscular and metabolic disease in horses. Our work includes both diseases that are both clinically and economically important in the horse, as well as the use of the horse as a biomedical model.
I am a major contributor to the international equine genome mapping effort and study the molecular and genetic basis of metabolic, neuromuscular and musculoskeletal disease in dogs and horses. I also collaborate on the identification of genomic signatures of selection for performance traits and the functional underlying alleles in the horse.
My research area is neuroimmunology. My lab uses a mouse model to study multiple sclerosis and pain in humans. The mouse model is a virus-induced disease and we study the immune response that leads to demyelinating disease and treatments to reduce and/or prevent disease.
My primary research currently is in epilepsy, genetics, metabolic disease, neurologic disorders, molecular medicine, neuromodulation, electrophysiology, and comparative medicine. Much of the research is in naturally occurring canine models for the sake of dogs and as translational for human research including epilepsy, neuropathies, and calcium oxalate urolithasis.
I am currently running 3 clinical trials in dogs with brain tumors looking at novel therapies that may translate to human medicine. I also am developing a new model of a chronic critical size defect in goat tibias also to be used the large animal model used to test and compare novel bone regenerative therapies for translation into human orthopedic disease. I am also using a swine model to test treatment of traumatic brain injury and a sheep model of osteoporosis to examine the effects of PTH.
Our laboratory studies the pathogenic mechanisms in the deer-origin prion disease, Chronic Wasting Disease (CWD), including: 1) mechanisms of neuronal pathology, 2) pathways of prion intestinal invasion, and 3) elucidation of the linkage between the accumulation of misfolded prion protein and the clinical symptoms of CWD. Additionally, our laboratory is seeking to refine the diagnosis and characterization of lymphoproliferative disease in the dog.
My research program is working to gain understanding of disease pathogenesis and to develop novel therapeutic approaches for HIV and Prion diseases.
I am interested in ecology, evolution, and epidemiology of infectious agents. My group uses a combination of epidemiological, evolutionary, and molecular tools to address - pathogen-host interactions, population genetic structure of microbes, and investigations on molecular mechanisms host adaptation, enhanced transmissibility and virulence.
The genetic and nutritional basis for equine neurologic and muscle disorders including Shivers, rhabdomyolysis and other myopathies.
My primary area of research is pain mechanisms. We also have ongoing projects on neuro-immune interactions in skin and intestinal mucosa.