My primary and active research areas involve diseases and injuries that occur at the human-animal interface. These often reflect new and emerging issues (i.e. C. difficile, MRSA) or evolving disciplines such as veterinary infection prevention in the clinic/hospital setting.
Investigating the mechanisms by which neuroimmune signaling processes influence the interactions of microorganisms with mucosal epithelial cells located on internal body surfaces susceptible to infection.
Morphological and MRI studies of osteoarthritis and osteochondrosis.
Our research lab is focused on understanding the role of host responses in the pathogenesis of viral infections, with a substantial effort devoted to investigating the impact of neuroinflammation on CNS viral disease and in promoting recovery from brain damage. We use a mouse model of herpes encephalitis to study the impact of specific immune components of the virus-induced inflammation cascade on neurogenesis in the adult brain. We also investigate immune responses to viral infections in farm animals, most notably swine. Using these animal models, we study mechanisms of disease and emergence of novel viruses like swine influenza virus and porcine epidemic diarrhea virus (PEDv).
Anatomic pathology as it relates to infectious diseases, agriculture, public health and biomedical research.
The broad aim of my research program is to understand infectious disease dynamics within wild animal populations, within domestic animal populations, and at the interface between wild and domestic animals.
Infectious disease epidemiology in pigs including foodborne and zoonotic pathogens, and occupational health and safety
Main focus is diagnostic bacteriology and development/evaluation of diagnostic tests. Research involves enteric diseases of animals caused by bacteria, especially Lawsonia, Brachyspira, and Campylobacter species.
Dr. Goyal's research interests include diagnosis, pathogenesis and control of viral infections in livestock and poultry and the development of methods for the detection and prevention of human and animal viruses in food, water and environment.
Research to support public policy-making in the areas of animal health, food safety and public health. Using risk analysis tools to support decision-making for preparedness and response. One Health competencies and leadership.
My laboratory is studying the molecular basis of pathogenesis of two pathogens: Escherichia coli and Salmonella enterica serovar Typhimurium. A common theme in each project is the identification of unique genes required for pathogenesis, understanding the functions of those genes, and determining the mechanisms controlling their expression.
I have two primary research areas: 1) understanding the mechanisms of plasmid dissemination associated with antibiotic resistance in bacterial pathogens; and 2) understanding the succession of the microbial communities in the animal gastrointestinal tract related to health and development. I work primarily with multidrug resistance-encoding plasmids of E. coli and Salmonella humans and production animals. The goal of this work is to understand the spread of these plasmids within and between human and animal bacterial populations. I also work closely with the poultry industries to study the bacterial populations inhabiting the gastrointestinal tracts of turkeys and chickens. The goal of this work is to understand the succession of bacterial communities over time, and how the modulation of these communities can be achieved using non-antibiotic alternatives.
Molecular mechanisms of infectious disease resistance in swine using relevant viral infection models.
I am currently running 3 clinical trials in dogs with brain tumors looking at novel therapies that may translate to human medicine. I also am developing a new model of a chronic critical size defect in goat tibias also to be used the large animal model used to test and compare novel bone regenerative therapies for translation into human orthopedic disease. I am also using a swine model to test treatment of traumatic brain injury and a sheep model of osteoporosis to examine the effects of PTH.
Risk analysis of food safety and animal health issues Antibiotic resistance of foodborne pathogens.
I seek to identify cost-effective and efficacious interventions for reducing foodborne pathogen contamination of meat and for minimizing the development and spread of antibiotic resistance in bacteria.
Understanding transmission of influenza virus and other swine viruses and designing strategies to control and eliminate influenza infections.