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  Home > Swine Diseases > Influenza


Influenza Research at the UMN (Areas of research focus, accomplishments and highlights)

• Validation of oral fluids for influenza virus and sensitivity of detection in vaccinated and non-vaccinated populations
• Assessment of the effect of vaccination to reduce influenza transmission
• Assessment of the effect of maternal immunity on influenza spread
• Validation of air collection methods to study airborne influenza in pigs
• Characterization of influenza viruses affecting US swine

Recent Publications

*Detmer SE, Patnayak DP, Jiang Y, Gramer MR, Goyal SM. Detection of Influenza A virus in porcine oral fluid samples. J Vet Diagn Invest. 2011 Mar;23(2):241-7. PubMed PMID: 21398442.

*Evseenko VA, Boon AC, Brockwell-Staats C, Franks J, Rubrum A, Daniels CS, Gramer MR, Webby RJ. Genetic composition of contemporary swine influenza viruses in the West Central region of the United States of America. Influenza Other Respi Viruses. 2011 May;5(3):188-97. DOI: 10.1111/j.1750-2659.2010.00189.x. Epub 2011 Jan 25. PubMed PMID: 21477138; PubMed Central PMCID: PMC3079267.

*Lorusso A, Vincent AL, Harland ML, Alt D, Bayles DO, Swenson SL, Gramer MR, Russell CA, Smith DJ, Lager KM, Lewis NS. Genetic and antigenic characterization of H1 influenza viruses from United States swine from 2008. J Gen Virol. 2011 Apr;92(Pt 4):919-30. Epub 2010 Dec 22. PubMed PMID: 21177926.

*Nelson MI, Lemey P, Tan Y, Vincent A, Lam TT, Detmer S, Viboud C, Suchard MA, Rambaut A, Holmes EC, Gramer M. Spatial dynamics of human-origin h1 influenza a virus in north american Swine. PLoS Pathog. 2011 Jun;7(6):e1002077. Epub 2011 Jun 9. PubMed PMID: 21695237; PubMed Central PMCID: PMC3111536.

*Romagosa A, Gramer M, Joo HS, Torremorell M. Sensitivity of oral fluids for detecting influenza A virus in populations of vaccinated and non-vaccinated pigs. Influenza and Other Respiratory Viruses. 2011 Jul 21. DOI: 10.1111/j.1750-2659.2011.00276.x. [Epub ahead of print] PubMed PMID: 21777397.

*Beaudoin A, Gramer M, Gray GC, Capuano A, Setterquist S, Bender J. Serologic survey of swine workers for exposure to H2N3 swine influenza A. Influenza Other Respi Viruses. 2010 May 1;4(3):163-70. PubMed PMID: 20409213; PubMed Central PMCID: PMC2859468.

*Ramakrishnan MA, Wang P, Abin M, Yang M, Goyal SM, Gramer MR, Redig P, Fuhrman MW, Sreevatsan S. Triple reassortant swine influenza A (H3N2) virus in waterfowl. Emerg Infect Dis. 2010 Apr;16(4):728-30. PubMed PMID: 20350405.

*Ramakrishnan MA, Gramer MR, Goyal SM, Sreevatsan S. A Serine12Stop mutation in PB1-F2 of the 2009 pandemic (H1N1) influenza A: a possible reason for its enhanced transmission and pathogenicity to humans. J Vet Sci. 2009 Dec;10(4):349-51. PubMed PMID: 19934602; PubMed Central PMCID: PMC2807273.

*Ramakrishnan MA, Tu ZJ, Singh S, Chockalingam AK, Gramer MR, Wang P, Goyal SM, Yang M, Halvorson DA, Sreevatsan S. The feasibility of using high resolution genome sequencing of influenza A viruses to detect mixed infections and quasispecies. PLoS One. 2009 Sep 22;4(9):e7105. PubMed PMID: 19771155; PubMed Central PMCID: PMC2740821.

Torremorell M, Juarez A, Chavez E, Yescas J, Doporto JM, Gramer M. Procedures to eliminate H3N2 swine influenza virus from a pig herd. Vet Rec. 2009 Jul 18;165(3):74-7. PubMed PMID: 19617611

Vincent AL, Ma W, Lager KM, Gramer MR, Richt JA, Janke BH. Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States. Virus Genes. 2009 Oct;39(2):176-85. PubMed PMID: 19597980.

Vincent AL, Lager KM, Janke BH, Gramer MR, Richt JA. Failure of protection and enhanced pneumonia with a US H1N2 swine influenza virus in pigs vaccinated with an inactivated classical swine H1N1 vaccine. Vet Microbiol. 2008 Jan 25;126(4):310-23. Epub 2007 Jul 17. PubMed PMID: 17719188

*Gramer MR, Lee JH, Choi YK, Goyal SM, Joo HS. Serologic and genetic characterization of North American H3N2 swine influenza A viruses. Can J Vet Res. 2007 Jul;71(3):201-6. PubMed PMID: 17695595; PubMed Central PMCID: PMC1899866.

Lee JH, Gramer MR, Joo HS. Efficacy of swine influenza A virus vaccines against an H3N2 virus variant. Can J Vet Res. 2007 Jul;71(3):207-12. PubMed PMID: 17695596; PubMed Central PMCID: PMC1899867

Ma W, Vincent AL, Gramer MR, Brockwell CB, Lager KM, Janke BH, Gauger PC, Patnayak DP, Webby RJ, Richt JA. Identification of H2N3 influenza A viruses from swine in the United States. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20949-54. Epub 2007 Dec 18. PubMed PMID: 18093945; PubMed Central PMCID: PMC2409247

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