Connie Gebhart

NAME: Connie J. Gebhart

ACADEMIC RANK : Assistant Professor

DEPT:
Veterinary and Biomedical Sciences
257B Vet Sci Bldg
1971 Commonwealth Ave
St Paul, MN 55108
Phone: (612) 624-3444
Fax: (612) 625-5203
E-mail: gebha001@umn.edu

EDUCATION AND SPECIALTY TRAINING:
Ph.D. "Proliferative enteropathy"-Veterinary Microbiology, University of MN, 1987.
M.S. "Proliferative enteropathy"-Veterinary Microbiology, University of MN, 1983.
B.S. - Medical Technology, North Dakota State University. With Honors, 1977.

MAJOR ACADEMIC INTERESTS:
Veterinary microbiology with emphases on diagnostic microbiology and molecular biology.

CURRENT RESEARCH PROJECTS AND SUPPORT:
Co-investigator:
Whole genome sequencing of Lawsonia intracellularis.
USDA IFAFS
09/01/2000 to 08/31/2003

Improved antemortem diagnosis of proliferative enteropathy in horses.
Minnesota Equine Research Center
07/01/1999 to 06/03/2000

Primary Investigator:
Susceptibility testing of L. intracellularis vaccine strains.
Boehringer Ingelheim Vetmedica
06/01/2003 to 5/31/2004

Passive L. intracellularis protection using egg antibodies
MN Pork Producers
05/01/2003 to 09/01/2004

Porcine proliferative enteropathy pathogenesis.
Elanco Animal Health
06/01/2001 to 12/31/2003

Lawsonia intracellularis immunity.
Boehringer Ingelheim, Ltd.
01/01/2001 to 12/31/2002

Cell-mediated immune response of L. intracellularis.
National Pork Producers Council
05/01/2001 to 04/30/2002

Hamster challenge model for proliferative enteropathy
Fleming Laboratories, Inc.
08/01/2001 to 07/31/2002

In vitro growth of L. intracellularis.
Pfizer Animal Health
12/01/1999 to 06/30/2001

Determination of MICs of CP-472 against L. intracellularis.
Pfizer Animal Health
03/15/1999 to 12/31/2001

Isolation and growth of new strains of Lawsonia intracellularis from the United States and Europe for phenotypic and genotypic comparisons.
Boehringer Ingelheim / NOBL Labs, Inc.
11/01/1998 to 10/31/2000

Molecular discrimination of Lawsonia intracellularis isolates.
Boehringer Ingelheim / NOBL Labs, Inc.
4/1/1998 to 3/31/2000

Expression of major proteins of the agent of proliferative enteropathy.
National Pork Producers Council
07/01/1994 to 10/01/2000

PUBLICATIONS SINCE 1993:
Guedes, R.M.C. and C. J. Gebhart. 2003. Polyclonal and monoclonal antibodies for diagnosis of proliferative enteropathy. J. Vet. Diag. Investi. (in press).

Guedes, R.M.C., N.L. Winkelman, and C.J. Gebhart. 2003. Severity of porcine proliferative enteropathy is dose dependent. Vet. Rec. (in press).

Guedes, R.M.C. and C.J. Gebhart. 2003. Onset and duration of fecal shedding, cell-mediated and humoral immune responses after challenge with a pathogenic isolate or a commercial vaccine of Lawsonia intracellularis. Vet. Microbiol. 91:135-145.

Guedes, R.M.C. and C.J. Gebhart. 2003. Comparison of pure culture of Lawsonia intracellularis and intestinal mucosa homogenate as challenge models for porcine proliferatie enteropathy. Vet. Microbiol. 93:159-166.

Guedes, R.M.C. and C.J. Gebhart. 2002. Proliferative enteropathy (Ileitis): learning how to use and interpret diagnostic tests. Internat. Pigletter 22:19-23.

Guedes, R.M.C., C.J. Gebhart, G.A. Armbruster, and B.D. Roggow. 2002. Serologic follow-up of a repopulated swine herd after an outbreak of proliferative hemorrhagic enteropathy. Can. J. Vet. Res. 66:258-263.

Guedes, R.M.C., C.J. Gebhart, N.L. Winkelman, R.A. Mackie-Nuss, T.A. Marsteller and J. Deen. 2002. Comparison of different methods for diagnosis of porcine proliferative enteropathy. Can. J. Vet. Res.66:99-107.

Guedes, R.M.C., C.J. Gebhart, N.L. Winkelman, and R.A. Mackie-Nuss. 2002. A comparative study of an indirect immunofluorescent test and an immunoperoxidase monolayer assay for the diagnosis of porcine proliferative enteropathy. J. Vet. Diag. Investi. 14:420-423.

Guedes, R.M.C., C.J. Gebhart, J. Deen and N.L. Winkelman. 2002. Validation of an immunoperoxidase monolayer assay as a serologic test for porcine proliferative enteropathy. J. Vet. Diag. Investi.14:528-530.

Zhang, P., C.J. Gebhart, D. Burden, and G.E. Duhamel. 2000. Improved diagnosis of porcine proliferative enteropathy caused by Lawsonia intracellularis using polymerase chain reaction-enzyme-linked oligosorbent assay (PCR-ELOSA). Mol. and Cell. Probes 14:101-108.

Lavoie, J.P., R. Drolet, D. Parsons and C.J. Gebhart. 2000. Equine proliferative enteropathy: a cause of weight loss, colic, diarrhea and hypoproteinemia in foals on three breeding farms. Equine Vet. J. 32:418-425.

Schumacher, J., J. Schumacher, M. Rolsma, K.V. Brock, and C.J. Gebhart. 2000. Surgical and medical treatment of an Arabian filly with proliferative enteropathy caused by Lawsonia intracellularis. J. Vet. Intern. Med. 14:630-632.

Lawson, G.H.K. and C.J. Gebhart. 2000. Proliferative Enteropathy (Review). J. Comp. Pathol. 122:77-100.

Klein, E.C., C.J. Gebhart, and G.E. Duhamel. 1999. Fatal outbreaks of proliferative enteropathy caused by Lawsonia intracellularis in colony-raised Rhesus Macaques (Macaca mulatta). J. Med. Primatology 28:11-18.

Frank, N., C.E. Fishman, C.J. Gebhart, and M. Levy. 1998. Lawsonia intracellularis proliferative enteropathy in a weanling foal. Equine Vet. J. 30:549-552.

Duhamel, G.E., E.C. Klein, R.O. Elder, and C.J. Gebhart. 1998. Subclinical proliferative enteropathy in sentinel rabbits associated with Lawsonia intracellularis. Vet. Pathol. 35:300-303.

Cooper, D.M., and C.J. Gebhart. 1998. Comparative aspects of proliferative enteritis. Am. J. Vet. Res. 212:1446-1551.