Meet the VMED Students
Graduate Students in Veterinary Medicine
MS and PhD students in VMED are engaged in research related to animal and human health and welfare. Our students study infectious and zoonotic diseases, the development of novel treatments for cancer and other diseases, genetic research and therapies, virology and bacteriology, and ecosystem and wildlife health, among other areas of research.
M.S. Veterinary Medicine, University of Minnesota, 2012
D.V.M., Universidad Complutense Madrid, 2003
Dr. Peter Davies & Dr. Montserrat Torremorell
My research focuses on the characterization of particle size ranges that are associated with airborne viruses in swine aerosols, under controlled and field conditions, to better understand the mechanisms of disease transmission within and between farms
Alonso, C; Goede, DP; Morrison. RB; Davies, PR; Marthaler, DG; Torremorell, M; Evidence of long-distance transport and infectivity of airborne porcine epidemic diarrhea virus. Vet Res. (2014)July 14, 45(1):73
Alonso, C; Davies, P.R; Polson, D. D; Dee, S. A; Lazarus, W. F. Financial implications of air filtration systems for preventing PRRSV infection in large sow herds. Prev Vet Med. (2013) Sep 1;111(3-4):268-77
Alonso, C; Murtaugh, M. P; Dee, S. A; Davies, P.R .Epidemiological study of air filtration systems for preventing for preventing PRRSV infection in large sow herds. Prev Vet Med. (2013) Oct 1;112(1-2):109-17
Alonso C, Otake S, Davies P, Dee S. An evaluation of interventions for reducing the risk of PRRSV introduction to filtered farms via retrograde air movement through idle fans. Vet. Microbiol. (2012), 157, 3-4, 304-10
Alonso C, Raynor P, Davies P, Torremorell M. Effect of the electrostatic particle ionization technology on PRRSV and influenza aerosols under experimental conditions. American Association of Swine Veterinarians Conference. Dallas, Texas, USA; 2014
Alonso C, Raynor P, Davies P, Torremorell M. Electrostatic Particle Ionization (EPI) system as a means to decrease artificially generated PRRSV aerosols. International PRRSV Symposium. Chicago, Illinois, USA; 2013
Alonso C, Raynor P, Davies P, Torremorell M. Preliminary data on the effect of electrostatic particle ionization system on decreasing infectious aerosols. Allen D. Leman Swine Conference-Carlos Pijoan SDEC Symposium: Scientific Challenges and Approaches to Regional Disease Control. St. Paul, Minnesota, USA; 2013
Alonso C, Dee S, Polson D, Davies P. Phylogenetic evaluation of historic PRRSV isolates from air filtered sow herds in North America. American Association of Swine Veterinarians Conference. San Diego, California, USA; p. 65, 2013
Alonso C, Dee S, Davies P. Payback period for air filtration systems in large sow herds targeting the prevention of PRRSV entry- Partial budget analysis. Allen D. Leman Swine Conference-Carlos Pijoan SDEC Symposium: Managing filtered farms. St. Paul, Minnesota, USA; 2012
Alonso C, Dee S, Davies P. Epidemiological evaluation of air filtration in large sow herds in North America. International Symposium on Veterinary Epidemiology and Economics-ISVEE. Maastricht, Netherlands; p. 86, 2012
Alonso C, Dee S, Davies P, Lazarus W. Economic evaluation of air filtration systems for PRRSV in large sow herds in a swine dense region in North America. International Pig Veterinary Society Congress-IPVS. Jeju Island, South Korea; Volume 2, p. 994, 2012
Carlos Pijoan Scholarship. CVM, University of Minnesota (January 2014)
University of Minnesota Distinguished Master's Thesis Award. College of Veterinary Medicine University of Minnesota (October 2013)
OGP Graduate Education Travel Award. College of Veterinary Medicine University of Minnesota (April 2013)
Awarded poster. Allen D. Leman Swine Conference. Economic evaluation of air filtration systems for PRRSV in large sow herds in North America (September 2012)
1st Prize Oral. Biosafety and Biosecurity Award from the Animal Health Institute-Joseph J. Garbarino Foundation. Conference of Research Workers in Animal Diseases 2011. An evaluation of interventions for reducing the risk of PRRSV introduction to filtered farms via retrograde air movement through idle fans (back-drafting) (December 2011)
B.S., Animal Science, University of Minnesota, 2012
Dr. Molly McCue
Bueno Padilla, Irene
M.P.H. University of Minnesota, 2013
D.V.M., University of Cordoba, Spain, 2007
Dr. Srinand Sreevatsan
I am interested in ecosystem health research-specifically the disease dynamics at the interface between wildlife, humans and the environment.
Bueno Padilla, I; Klauss, G; Gardiner, C.H; Wuenschmann, A. Disseminated mite infection with ocular involvement in a juvenile bald eagle (Haliaeetus leucocephalus). Veter. Ophthalmol. J. 15(4): 271-275. 2012.
Rutkiewicz, J; Nam, D; Cooley, T; Neumann, K; Bueno Padilla, I; Route, W; Strom, S; Basu, N. ‘Mercury exposure and neurochemical impacts in bald eagles across several Great Lakes states’. Ecotoxicol. July 2011.
Bueno-Padilla, I; Arent, L; Ponder, J. ‘Tips for Raptor Bandaging’. Exotic DVM, Volume 12, Issue 3. 2010.
Willette, M; Ponder, J; Cruz, L; Arent L; Bueno, I; Nicolas, O; Redig,P. ‘Management of Select Bacterial and Parasitic Conditions of Raptors’. Veter. Clinics N. Amer.- Exotic Animal Practice. September 2009.
Bueno, I.; Redig, PT.; Ponder, J.; Willette, M. Bullets and bald eagles: Developing a model for dealing with conflicts in ecosystem health. The Wildlife Society, Milwaukee, WI. October 6th 2013.
Bueno-Padilla, I.; Redig, P.T.; Willette, M.; Ponder, J. Socio-economical and political aspects of spent lead ammunition. Wildlife Disease Association. Knoxville, Tennessee. July 2013.
Bueno-Padilla, I.; Smith, K.; Travis, D.; Machalaba, C.; Karesh, W.B. A tool to assess the public health risks of wildlife importation into the United States: The case of rodents from Latin America. Wildlife Disease Association. Knoxville, Tennessee. July 2013.
Bueno, I. Treatment of lead intoxication in raptors. National Wildlife Rehabilitation Association Symposium. Baton Rouge, LA. March 2012.
Bueno, I. Raptor Tissue Sampling and Necropsy. Raptor Research Foundation Conference. Duluth, Minnesota. October 2011.
B.S., Biochemistry and Animal Science, Berry College
Dr. Carol Cardona
My research interest is viral disease pathogenesis with a focus on influenza A viruses. My current research is directed toward the stability of the viral envelope under varying environmental conditions. I am interested in the viral and host factors that determine transmissibility of influenza A viruses in poultry species.
NIFA Fellowship in Food Animal Biosecurity: Infectious Disease Ecology, 2013-2016
D.V.M., Universidad Central de Ecuador
Dr. Srinand Sreevatsan & Dr. Montse Torremorell
My research interest seeks to understand the effect of control measures like vaccination over genetic and antigenic evolution and variation of Influenza A virus in pig populations, especially in breeding herds.
Clavijo, Maria Jose
D.V.M - Universidad Central de Venezuela 2009
Dr. Albert Rovira & Dr. Robert Morrison
The focus of my research is gaining knowledge on the epidemiology of Mycoplasma hyorhinis by developing highly specific and sensitive diagnostic and genotyping tools that would aid in the establishment of proper prevention and control measures for this pathogen.
Clavijo M.J., Oliveira S. (2009). Development of a quantitative real-time PCR for the detection of Actinobacillus suis in clinical samples. Proceedings of the 40th Annual Meeting of the American Association of Swine Veterinarians, Dallas, Texas.
Clavijo M.J., Oliveira S. (2008). Molecular characterization of Streptococcus suis isolates recovered from U.S. swine herds – unraveling the human link. Proceedings of the 39th Annual Meeting of the American Association of Swine Veterinarians, San Diego, California.
Clavijo MJ, Rovira A, Murray D, Oliveira S (2011) Mycoplasma hyorhinis: Epidemiology of infection in endemically infected farms. Proceedings of the 40th Annual Meeting of the American Association of Swine Veterinarians, Phoenix, Arizona.
Clavijo MJ, L Bruner, S Olson, EL Rosey, D Pearce, A Rovira (2012) Dynamics of Mycoplasma hyorhinis infection in clinically affected swine herds. Proceedings of the 22nd International Pig Veterinary Society Congress, Jeju, South Korea.
Clavijo MJ, L Bruner, S Olson, EL Rosey, D Pearce, A Rovira (2012) Dynamics of Mycoplasma hyorhinis infection in clinically affected swine herds. Proceedings of the XLVII Congreso de la Asociacion Mexicana de Especialistas en Cerdos, Guadalajara, Mexico.
Clavijo MJ, A Rovira (2012) Mycoplasma hyorhinis: Que provoca y como buscarlo? In: Proceedings of 15 Foro Porcino Pfizer, Barcelona, Spain. October 1st and 2nd.
Clavijo MJ, (2013). Insight into Mycoplasma hyorhinis. Pork community webcast Pfizer Animal Health. January 18th 2013.
Clavijo MJ (2013). Actualidades sobre M. hyorhinis y M. hyosynoviae. Boehringer Ingelheim Vetmedica “Se habla en español”. February 25th 2013.
Co-investigator: Characterization of Mycoplasma hyorhinis transmission and spread within endemically infected populations National Pork Board. Funded $49,685 May 2010.
Principal investigator: Emerging and Zoonotic Diseases Signature Program Mentored Research. Funded $7,000 August 2011.
Co-investigator: Characterization of the genetic diversity of Mycoplasma hyorhinis field isolates by multiple locus variable number of tandem repeats analysis (MLVA) and multi-locus sequence typing (MLST). National Pork Board. Funded $35,000 May 2012.
Co-investigaotr: Comparison of different times of Draxxin administration for the control of Mycoplasma hyorhinis disease. Pfizer animal Health Draxxin 2012 call for abstracts. Funded $25,273 December 2012.
Veterinary Student of the year 2006-2007. Universidad Central de Venezuela.
Scientific Merit 2008. Facultad de Ciencias Veterinarias - Universidad Central de Venezuela.
Student session oral presentation: Scholarship awarded by the American Association of Swine Veterinarians at 39th Annual Meeting 2008 - Student session oral presentation.
Student session oral presentation: Scholarship awarded by the American Association of Swine Veterinarians at the 40th Annual Meeting 2008.
Carlos Pijoan Fellowship at the College of Veterinary Medicine of the University of Minnesota Graduate Program, Fall 2010.
AAVLD-sponsored Trainee Travel Award 2011. AAVLD annual meeting.
First place in poster competition. Research Days 2012, College of Veterinary Medicine, University of Minnesota. Poster entitled: Dynamics of Mycoplasma hyorhinis infection in two commercial swine herds.
D.V.M., The Ohio State University, 2013
B.S., Animal Sciences, with specialization in animal biology, University of Florida, 2009
Dr. Troy Trumble
My research explores the use of biomakers in the synovial fluid of the tibiotarsal joint to determine the severity of osteoarthritis (OA) in the distal intertarsal (DIT) and tarsometatarsal (TMT) joints of horses. Currently, the most accurate method of identifying OA in these joints is a combination of thorough physical, lameness, and radiographic examinations. Molecular biomarkers of OA reflect quantitative and dynamic variations associated with joint metabolism. The specific aims are to: (1) define the direct and indirect biomarker concentrations in synovial fluid, and (2) validate/refute that the biomarker concentrations in these joints increase with severity of OA in the distal joints.
The Ohio State University’s research grant for a project titled “Pregnancy Diagnosis before the Collection and Transfer of Horse Embryos”
Albert Schweitzer Fellowship Award, 2011.
Diaz, Carlos Andres
M.S., National University of Colombia, 2010
D.V.M., National University of Colombia, 2005
Dr. Montserrat Torremorell
My research is focused on the diversity and evolution of Influenza A viruses in pig populations. Influenza A is a main cause of respiratory disease in pigs and a public health threat. I use next-generation sequencing technologies to reconstruct the viral population and understand the genetic factors that allow the virus to persist in swine populations for prolonged periods of time.
Diaz A. Enomoto S. Romagosa A. Sreevatsan S. Nelson M. Culhane M. Torremorell M. Genome plasticity of a triple reassortant H1N1 influenza A virus during infection of vaccinated pigs. Submitted for publication.
Diaz A. Allerson M. Culhane M. Sreevatsan S. Torremorell M. Antigenic drift of H1N1 influenza virus in pig with and without passive immunity. Influenza and Other Respir Viruses 2013 dec: 7 Suppl 4:52-60 doi: 10.1111/irv.12190.
Torremorell M, Allerson M, Corzo C, Diaz A, Gramer M. Transmission of influenza A virus in pigs. Transbound Emerg Dis. 2012; 59:68-84 .
Diaz A. Rodriguez N. Vera V. Ramirez G. Casas G. Mogollon D. Characterization of pig farms in the main swine producing regions of Colombia. Rev Colomb Cienc Pecu 2011;24:131-144
Diaz A. Jaime J. Vera V. Rodriguez N. Casas GA. Mogollon JD. Postweaning multisystemic wasting syndrome: epidemiological issues. Rev Med Vet Zoot
Diaz A. Corzo C. Culhane M. Sreevatsan S. Torremorell. M. Co-circulation of influenza A viruses in swine populations. Allen D. Leman Swine Conference. Saint Paul,MN, USA 2014
Diaz A. Torremorel M. Culhane M. Sreevatsan S. Complete genome characterization of influenza A virus in sow herds. MISM Influenza workshop. Fogarty International Center. NIH. Bethesda, MD. 2014
Diaz A. Swine Influenza A virus. V national Symposium on virology. I Latin-American congress on virology. Pontificia Universidad Javeriana Bogota, Colombia 2013.
Diaz A. S. Enomoto. Corzo C. Culhane M. Sreevatsan S. Torremorell M. Influenza A virus infection and diversity in commercial pig herds. AASV Meeting Dallas, TX 2014
Diaz A. Enomoto S. Culhane M. Sreevatsan S. Torremorell M. Use of NGS to study within-host and between host diversity of influenza. USDA-NIH MISMS WORKSHOP. USDA NATIONAL Centers for animal health, Ames, IA 2013.
Diaz A. Torremorell M. Influenza infection in the sow herd. Allen D. Leman Swine Conference. Saint Paul MN, USA, 2012.
Diaz A. Enomoto S. Sreevatsan S. Gramer M. Torremorell M. Full genome of swine influenza A virus subtype H1N1 using next generation sequencing. IPVS. Jeju, South Korea 2012.
Diaz A. Allerson M. Romagosa A. Gramer M. Sreevatsan S. Torremorell M. Influenza A virus diversity in immune pigs. CRWAD. Chicago, IL 2011.
University of Minnesota Doctoral Dissertation Fellowship, 2014-2015
Scholarship to attend the 19th summer institute in statistical Genetics. Module 9 and 14 University of Washington. 2014
Scholarship to attend the 6th Summer Institute in Statistics and Modeling in Infectious Diseases. Module 14. University of Washington, 2014
MnDrive student fellowship. MnDrive Global food supply initiative. 2013-2014
CVM student travel award. University of Minnesota, 2014
Veterinary medicine graduate students’ representative to the Program Advisory Committee, 2013
Vaughn Larson Award. CVM, University of Minnesota, 2013
Carlos Pijoan scholarship. CVM, University of Minnesota, 2012
CVM student travel award. University of Minnesota, 2012
Caldas scholarship. Colombian Government. 2010
M.Phil., Microbiology, University of Peradeniya, Sri Lanka, 2004
B.V.Sc., University of Peradeniya, Sri Lanka, 1996
Dr. Mathur Kannan
Our lab is interested in the gene CD38 and its role in the pathogenesis of asthma. Previous studies from our lab showed that it is playing a role in hyper-responsiveness and inflammation, two of the cardinal features of asthma. Further it was shown that TNF-alpha induced CD38 expression is transcriptionally regulated by transcription factors NFK-B and AP-1 through MAPK pathway. My aims are to determine whether CD38 has a role in remodeling of airways, another feature of asthma and to find out whether CD38 is post-transcriptionally regulated by microRNAs.
Dileepan, M., Wijewardana, T.G., Horadagoda, N.U., Stipkovits, L., Varga, I and Dharmawardena, I.V.P. (2005). Evidence of Mycoplasma hyopneumoniae infection among slaughtered pigs in Sri Lanka. Tropical Animal Health and Production, 37(1): 21-23
Dileepan.M., Wijewardana T.G., Horadagoda N.U. and Dharmawardena,I.V.P. (2002). Serological evidence for the presence of Mycoplasma hyopneumoniae in pigs in Sri Lanka. Sri Lanka Veterinary Journal. 49(1A): 1-4
Dileepan, M., Wijewardana, T.G., Horadagoda, N.U. and Dharmawardana, I.V.P. (2001). An abattoir study on the aetio-pathology of lung lesions in pigs in Sri Lanka. Sri Lanka Veterinary Journal. 48(1A): 1-8
Dileepan, M., Wijewardana, T.G., Horadagoda, N.U.and Townsend, M. Kirsty. (2001). Screening for toxigenic Pasteurella multocida among isolates recovered from tonsils and lungs of pigs. Sri Lanka Veterinary Journal. 48(1A): 17-19
B.V.M.S., Glasgow University, 2009
Dr. Stephanie Valberg
My masters project is looking at horses with suspected immune mediated myositis, trying to identify the underlying cause and if there is a genetic link.
Durward-Akhurst SA, Mair TS, Boston R, Dunkel B. Comparison of two antimicrobial regimens on the prevalence of incisional infections after colic surgery. Vet Rec. 2013 Mar 16;172(11):287
Naylor RJ, Durward-Akhurst SA. Use of the Accutrend Plus point-of-care monitor for blood triglyceride measurement in horses. Vet Rec. 2012 Mar 3;170(9):228.
D.V.M., University of Minnesota, 2013
B.S., Agricultural Biochemistry, Iowa State University, 2009
Dr. Peter Davies
D.V.M., Ross University School of Veterinary Medicine, 2010
B.S., Biology, Ursinus College, 2007
Dr. Lynelle Graham & Dr. Alice Larson
My research focuses on pain as it relates to the brown adipose tissue in mice as well as tramadol pharmacokinetics in dogs.
D.V.M., Kasetsart University, Thailand, 2005
Dr. John Deen
My research is focused on creating Bayesian epidemiologic models to describe the within-herd transmission of swine Influenza A virus (IAV) with various conditions of the swine production system. The epidemiological model can serve as a tool to bridge unconnected pieces of information obtained from several places in order to provide insights into the underlying process of the IAV transmission. With the goal of developing an effective IAV surveillance scheme, Bayesian epidemiological models are proposed to describe and predict the IVA transmission within the swine herd conditional to piglet production batching, gilt replacement, and vaccination programs.
Kanjanapruthipong, J., N. Homwong and N. Buatong. 2010. Effects of prepartum roughage neutral detergent fiber levels on periparturient dry matter intake, metabolism, and lactation in heat-stressed dairy cows. J. Dairy Sci. (93): 2589-2597
Chairattanasat, C., O. Songserm, N. Homwong and N. Paraksa. 2009. Effect of Crude Extract Product from Capsicum spp. Supplementation in Sow Dies on Passive Immunity in Piglets. Agriculture Sci. J. (1):65-72
Rukkwamsuk, T., N. Homwong, W. Bumkhuntod, P. Rohitakanee and R. Sukcharoen. 2006. Negative Energy Balance in Periparturient Diary Cows Raised in Small-Holder Farms in Kamphaengsaen District, Nakhonpathom Province. Kasetsart J. (Nat. Sci.) 40:1000-1004.
“A comparison of two lameness detection methods in sows: A search for the best method” 13th KVAC: International conference on Trans-boundary Disease; Impact on ASEAN One Health, June 7-8, 2012, Khon Kaen, Thailand.
“Estimating hiding behavior for lameness in sows,” Conference of research workers in animal diseases (CRWAD) annual meeting, December 5th, 2011, Chicago, Illinois, USA
“A simulation models for Influenza A virus dissemination in a growing pig herd with waning immunity” Points of Pride Research Day, October 2, 2013, Minnesota, USA
“Using discriminant analysis to estimate sow culling-decision error rate and its posterior probability based on lameness and productivity” Points of Pride Research Day, October 10, 2012, Minnesota, USA
D.V.M., Chulalongkorn University, Thailand, 2007
Dr. Jody Lulich & Dr. Carl Osborne
My research interest is focused on epidemiology of feline struvite urolithiasis, with emphasis on the association of the host, agent and environment factors to the development of struvite urolith in cats.
M.S., Comparative Biomedical Science, University of Wisconsin-Madison, 2012
Postgraduate Diploma, Applied Statistics, University of Peradeniya, Sri Lanka, 2010
BVSc., University of Peradeniya, Sri Lanka, 2008
Dr. Nicholas Phelps & Dr. Andres Perez
D.V.M., Iowa State University, 2012
B.S., Physics, Creighton University, 2006
Dr. Molly McCue
D.V.M., Konkuk University, Republic of Korea, 2010
Dr. Maxim Cheeran
D.V.M., Konkuk University, Republic of Korea, 2008
B.A., Mass Communication, Ewha Women's University, Republic of Korea, 2000
Dr. David Polzin
I am interested in acute kidney injury and chronic kidney disease in dogs and cats. My current research focuses on new renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), cystatin B, clusterin, and inosine to help an early detection of acute kidney injury in dogs and improve its prognosis.
D.V.M., University of Minnesota, 2014
B.S., Civil Engineering, University of Florida, 2006
Dr. Meggan Craft & Dr. Andres Perez
I am interested in understanding infectious disease dynamics in animal populations. My research focuses on developing a mathematical model to predict and control the spread of foot and mouth disease in swine.
Amy Kinsley, Roger Moon, Kirk Johnson, Michelle Carstensen, David Neitzel, Meggan Craft. Eastern equine encephalitis virus mosquito vectors in Minnesota (In Review, PLOS ONE)
North Central Mosquito Control Association 9th Annual Meeting. April, 2013. Ham Lake, Minnesota. EEE Vector Surveillance in Northern Minnesota.
116th Minnesota Veterinary Medical Association Annual Meeting (MVMA). February, 2013. Minneapolis, Minnesota. Public Heath emerging topics-Eastern Equine Encephalitis in Minnesota.
Conference of Research Workers in Animal Diseases (CRWAD). December 2012. Chicago, Illinois: The ecology of eastern equine encephalitis virus in Minnesota.
University of Minnesota College of Veterinary Medicine Points of Pride Research Day, October 2012. St. Paul, Minnesota: The ecology of eastern equine encephalitis virus in Minnesota.-Poster Competition-First Place Award
Merial-NIH National Veterinary Scholars Symposium, August 2012. Fort Collins, Colorado: The ecology of eastern equine encephalitis virus in Minnesota.-Poster Competition.
Career Development Program Fellowship, Center of Excellence for Emerging and Zoonotic Animal Diseases, 2014
Infectious Disease Dynamics and Data-Clinic on Dynamical Approaches to Infections Disease Data Travel Award (2014)
College of Veterinary Medicine, University of Minnesota-International Travel Grant-Infectious Disease Risk Assessment (2013)
University of Minnesota College of Veterinary Medicine, Quinlan-Litvak Scholarship Recipient (2013)
College of Veterinary Medicine, University of Minnesota-Summer Scholars Recipient (2012)
Summer Scholars Points of Pride Research Poster Award-1st Place (2012)
V.M.D., University of Pennsylvania, 2010
B.S., Animal Science, University of Vermont, 2006
Dr. Sandra Godden
My research focuses on the health, well-being, and behavior of the group housed, pre-weaned dairy calf. Currently, we are utilizing precision dairy technologies to investigate the relationship between sensor derived feeding, activity and temperature data and health. The goal of this work is to improve our understanding of normal calf behavior and to improve surveillance techniques that will help producers to improve calf health, performance and well-being at both the individual animal and group level.
NIFA Fellowship in Food Animal Biosecurity: Infectious Disease Ecology, 2013-2016
RK Anderson Fellowship, 2013
Lopes Leivas Leite, Fernando
M.S., Veterinary Microbiology and Immunobiology, Iowa State University, 2014
D.V.M., Federal University of Santa Maria, Brazil, 2011
Dr. Srinand Sreevatsan
My research interests are in microbiology and immunology. Specifically in investigating host-pathogen interactions to understand and discover mechanisms that may allow for the development of improved vaccines and diagnostics.
Fernando L. Leite, Timothy A. Reinhardt, John P. Bannantine, Judith R. Stabel. Envelope protein complexes of Mycobacterium avium subsp. paratuberculosis and their antigenicity. Veterinary Microbiology, 175 (2-4): 275-85, February 2015.
Marina C. Sinott, Luciana L. Dias de Castro, Fernando L. L. Leite, Tiago Gallina, Marlene T. De-Souza, Diogo F.L. Santos, Fabio P.L. Leite. Larvicidal activity of Bacillus circulans against the gastrointestinal nematode Haemonchus contortus in sheep. Journal of Helminthology, doi:10.1017/S0022149X14000844, 2014.
Fernando L. Leite, Kevin D Stokes, Suelee Robbe-Austerman, Judith R. Stabel. Comparison of fecal DNA extraction kits for the detection of Mycobacterium avium subsp. paratuberculosis by polymerase chain reaction. Journal of Veterinary Diagnostic Investigation 25 (1): 27-34, January 2013.
D’Avila Farias, Fernando Lopes Leivas Leite, Silvana Beutinger Marchioro, Bernardo Garziera Gasperin, Felipe Libardoni, Eduardo Kenji Masuda, Glaucia Denise Kommers, Luiz Francisco Irigoyen, Agueda Castagna de Vargas. Outbreak of Ovine Respiratory Mannheimiosis in Southern Brazil. Veterinária e Zootecnia 20(2): 255-260, June 2013.
Jackeline K. Kirinus, Luciana Pötter, Letícia T. Gressler, Fernando L. L. Leite, Agueda P. C. Vargas. Phenotypic profile and antimicrobial susceptibility of Streptococcus equi isolated from horses in southern Brazil. Pesquisa Veterinária Brasileira 31(3):231-238, March 2011.
Priscila M. S. Carmo, Agueda C. Vargas, Daniel R. Rissi, José C. Oliveira Filho, Felipe Pierezan, Ricardo B. Lucena, Fernando L. Leivas Leite, Claudio S. L. Barros. Outbreak of infectious bovine keratoconjunctivitis and haemonchosis causing mortality in calves. Pesquisa Veterinária Brasileira 31(5):374-378, May 2011.
2014: Lopes Leivas Leite F., Reinhardt T., Bannantine J., Stabel J. Envelope Protein Complexes of Mycobacterium avium subsp. paratuberculosis and their Antigenicity. Oral Presentation. 12th International Colloquium on Paratuberculsis (ICP). Parma, Italy.
2014: Lopes Leivas Leite F., Budziarek Eslabao L. Reinhardt T., Bannantine J., Stabel J. ZAP-70, CTLA-4 and Proximal T Cell Receptor Signaling in Cows Infected with Mycobacterium avium subsp. paratuberculosis. Poster Presentation. 12th ICP, Parma, Italy.
2014: L. L. Leite F., Reinhardt T., Bannantine J., Stabel J. Antigenicity of Envelope Protein Complexes of Mycobacterium avium subsp. paratuberculosis and insights in to T cell responses of infected animals. Seminar. National Animal Disease Center, Ames, IA.
2013: L. L. Leite F., Reinhardt T., Bannantine J., Stabel J. Antigenicity of Envelope Protein Complexes of Mycobacterium avium subsp. paratuberculosis. Oral Presentation. Conference of Research Workers in Animal Diseases (CRWAD), Chicago, IL.
2012: Leite F., Stabel J. Comparison of Fecal DNA Extraction Kits for the Detection of Mycobacterium avium subsp. paratuberculosis. Poster Presentation. 11th ICP, Sydney, Australia.
2010: L. L. Leite F, Herrmann G. P., Vidal C. E., Vargas A. C., Controlling brucellosis in a bovine herd in the state of Rio Grande do Sul. Poster Presentation. First Meeting of the Associação de Universidades Grupo Montevideo (AUGM), Santa Maria, Brazil.
2009: Leite F. L, Sá M., Bach B.C., Lovato, L.T., Lara V.M. Antimicrobial Resistance of Staphylococcus spp. Isolated from Ear Samples of Domestic Cats. Poster Presentation. 1st Latin-American Congress of Microbial Resistance. Santa Cruz do Sul, Brazil.
2008: Leite F. L, Sá M., Bach B.C., Lovato, L.T., Lara V.M., Staphylococcus spp. Isolated from Ear Swabs of Healthy Cats and their Antimicrobial Susceptibility. Poster Presentation. 35th Brazilian Veterinary Medicine Congress. Gramado, Brazil.
Helping Hand Award, International Association for Paratuberculosis, 12th International Colloquium on Paratuberculosis, Parma, Italy, 2014.
Graduate Competition Award, Best in vitro study, awarded by the American College of Veterinary Microbiologists – ACVM, CRWAD, Chicago, IL, 2013.
Travel Award, Iowa State University, Ames, IA, 2013
Inducted in to the honorary society for agriculture Gamma Sigma Delta, for high academic achievement, Iowa State University, Ames, IA, 2013.
Awarded Poster. First Meeting of the AUGM Health Committee. Santa Maria, RS, Brazil, 2010.
M.S., Federal University of Minas Gerais, Brazil, 2006.
D.V.M., Federal University of Minas Gerais, Brazil, 2005.
Dr. Montserrat Torremorell & Dr. Albert Rovira
My research focuses on investigating the use of antibiotics as a factor that influences Haemophilus parasuis colonization and its effect on immune response development. Currently, my interest is in evaluating whether H. parasuis colonization may elicit an immune response that will be protective and whether this response may be impaired by the use of antibiotics.
N. Macedo, A. Rovira, S. Oliveira, M. Torremorell. Effect of enrofloxacin on the carrier stage of Haemophilus parasuis in naturally colonized pigs. Canadian J. Veter. Res. Accepted on March 14, 2013.
A. Olvera, S. Pina, N. Macedo, S. Oliveira, V. Aragon, A. Bensaid, 2012. Identification of potentially virulent strains of Haemophilus parasuis using a multiplex PCR for virulence-associated autotransporters (vtaA). The Veter. J. 191:213–218.
N. Macedo, S.R. Oliveira, A.P. Lage, J.L. Santos, M.R. Araujo, R.M. Guedes, 2011. ERIC-PCR genotyping of Haemophilus parasuis isolates from Brazilian pigs. Veter. J. 188:362-364.
N. Macedo, G.M. Alghamdi, C.J. Gebhart, R.M. Guedes, 2008. Enteropatia proliferativa em Equinos. Ciência Rural. , v.38, p.889 - 897.
An experimental model to evaluate the effect of antibiotics on Haemophilus parasuis colonization and immunity, 44th American Association of Swine Veterinarians, March 2 - 5, 2013
Evaluation of the immunogenic and protective capacity of a transmembrane protein of Haemophilus parasuis, 22nd International Pig veterinary Society Congress, June 10 - 13, 2012
Enrofloxacin treatment affects the colonization stage of Haemophilus parasuis in weaned pigs, AASV, March 10-13, 2012
Development and validation of an ELISA test to detect antibodies against Haemophilus parasuis, AAVLD, September 29-October 5, 2011
Travel award, Veterinary Medicine Graduate Student Conference Travel Award, 2013
J. Lindsay Oaks Bacteriology Award (Best Oral presentation). 54th Annual Conference of the American Association of Veterinary Laboratory Diagnosticians (AAVLD). September 29-October 5, 2011.
Travel award: American Association of Veterinary Laboratory Diagnosticians (AAVLD) Foundation, 2011.
University Innovations - University of Minnesota, 2011.
B.V.Sc. & A.H., Bombay Veterinary College, Maharashtra Animal & Fishery Sciences University, India, 2010
Dr. Connie Gebhart
Swine Dysentery, caused by Brachyspira hyodysenteriae is a mucohemorragic diarrheal disease of grower-finisher pigs, responsible for significant economic losses globally. In addition, B. pilosicoli causes porcine intestinal spirochetosis, a chronic muco-diarrheal disease, and “B. hampsonii” causes a mucohemorrhagic diarrheal disease which is clinically indistinguishable from Swine Dysentery. Largely disappearing from the U.S. in the late 1980s, the disease has re-emerged across U.S. swine herds during the late 2000s. Broadly, I am interested in developing and implementing techniques useful in the diagnosis, prevention, control and treatment of porcine Brachyspira infections. My research involves validation of antimicrobial susceptibility testing techniques, their implementation for studying antimicrobial susceptibility patterns and investigation of potential resistance mechanisms of Brachyspira species. In addition, it involves molecular genotyping, phylogenetic analyses and molecular epidemiological studies to help elucidate the diversity, distribution, dissemination and potential evolutionary patterns of these pathogens. I am also interested in identifying potential virulence-associated genes/factors for B. hyodysenteriae and “B. hampsonii”, and their role in the pathogenesis of this disease.
Mirajkar N.S. and Gebhart C.J. ‘Antimicrobial susceptibility patterns of Brachyspiraspecies in U.S. swine herds’. Oral presentation, 6th International Conference on Colonic Spirochaetal Infections, Surrey, U.K., 2013.
Mirajkar N.S. and Gebhart C.J. ‘Molecular epidemiology of global Brachyspira hyodysenteriae isolates’. Oral presentation, 6th International Conference on Colonic Spirochaetal Infections, Surrey, U.K., 2013.
Mirajkar N.S. and Gebhart C.J. ‘Association of Brachyspira antibiograms with species and source’. Oral presentation, 2013 Allen D. Leman Swine Conference, Saint Paul, U.S.A., 2013.
Mirajkar N.S. and Gebhart C.J. ‘Validation of a broth microdilution method and investigation of in vitro antimicrobial susceptibilities of porcine Brachyspira species’. Oral presentation, 56th Annual Conference of the American Association of Veterinary Laboratory Diagnosticians, San Diego, California, U.S.A., 2013.
Mirajkar N.S. and Gebhart C.J. ‘Molecular characterization and epidemiology ofBrachyspira hyodysenteriae in U.S. swine herds’. Oral presentation, 56th Annual Conference of the American Association of Veterinary Laboratory Diagnosticians, San Diego, California, U.S.A., 2013.
Mirajkar N.S. and Gebhart C.J. ‘Molecular epidemiology of global Brachyspira hyodysenteriae isolates’. Poster presentation, CVM Points of Pride Research Day, University of Minnesota, Saint Paul, U.S.A. 2013.
Mirajkar N.S., Bekele A.Z., Chander Y and Gebhart C.J. ‘Diversity and distribution of “Brachyspira hampsonii” in U.S. swine herds’. Oral presentation, 23rd International Pig Veterinary Society Congress, Cancun, Mexico, 2014.
Mirajkar N.S., Bekele A.Z., Chander Y and Gebhart C.J. ‘Molecular characterization of emerging “Brachyspira hampsonii”, Poster presentation, 2014 Allen D. Leman Swine Conference, Saint Paul, U.S.A., 2014.
Mirajkar N.S. and Gebhart C.J. ‘Source and species of swine Brachyspira influence antibiogram profiles’. Poster presentation, CVM Points of Pride Research Day, University of Minnesota, Saint Paul, U.S.A. 2014.
Mirajkar N.S., Bekele A.Z., Chander Y and Gebhart C.J. ‘Diversity and distribution of a novel swine dysentery pathogen “Brachyspira hampsonii”.’ Oral presentation, 95th Conference of Research Workers in Animal Disease, Chicago, U.S.A., 2014.
Mirajkar N.S. and Gebhart C.J. ‘Understanding the Molecular Epidemiology and Global Relationships of Brachyspira hyodysenteriae from Swine Herds in the United States: A Multi-Locus Sequence Typing Approach’. PLoS ONE 9(9): e107176. doi: 10.1371/journal.pone.0107176
Mirajkar NS and Gebhart CJ ‘Identifying Dysentery Genotypes’. National Hog Farmer, Jan 2014.
Emerging and Zoonotic Diseases Graduate Fellowship 2014-2015, College of Veterinary Medicine, University of Minnesota.
Carlos Pijoan Graduate Student Fellowship in Swine Medicine 2014-2015, College of Veterinary Medicine, University of Minnesota, U.S.A.
MnDRIVE Global Food Supply Initiative Graduate Research Fellowship 2014-2015, University of Minnesota, U.S.A.
Travel Award for two oral presentations at the 6th International Conference on Colonic Spirochaetal Infections in U.K., provided by the VMED program, College of Veterinary Medicine, University of Minnesota, U.S.A.
J. Lindsay Oaks Best Student Bacteriology Award, 56th Annual Conference of the American Association of Veterinary Laboratory Diagnosticians, San Diego, U.S.A., 2013.
Trainee travel award for the 56th Annual conference of the American Association of Veterinary Laboratory Diagnosticians, San Diego, U.S.A., 2013.
Best poster presentation award in the Emerging and Zoonotic Diseases program at the CVM UMN Points of Pride Research Day, Saint Paul, U.S.A, 2013.
Young scientist award at the 6th International Conference on Colonic Spirochaetal Infections, Surrey, U.K., 2013.
AAA Scholars Abroad Program 2011 Award from the American Alumni Association, India, 2011.
Lotus Trust Graduate studies scholarship from the Lotus Trust foundation, India, 2011.
S.K. Patil Scholarship from the Shri Brihad Bhartiya Samaj foundation, India, 2011.
Travel award for graduate studies abroad from the Tatachem Golden Jubilee foundation, India, 2011.
Graduate education abroad grant from the Pirojshah Godrej foundation, India, 2011.
M.S., Microbiology, Zagazig University, 2010
B.S., Pharmacy, Zagazig University, 2004
Dr. Pam Skinner
The mucosal surfaces are critical sites of transmission of both HIV & simian immunodeficiency virus (SIV). I believe that the ability of a vaccine to induce mucosal immunity is important in order to prevent or reduce the dissemination of HIV and SIV by providing a first line of defense. Using the SIV-infected rhesus macaque as a model for HIV infection, my research focuses on evaluating the ability of CD8 T cell-vaccines to induce high levels of functional SIV-specific CD8 T cells in genital, rectal & lymphoid tissue. I am determining the localization, abundance, and phenotype of SIV-specific CD8 T cells in situ in genital, rectal & lymphoid tissue of vaccinated and control animals.
M.S., Veterinary Medicine, University of Minnesota, 2010
D.V.M., University of Nigeria, Nsukka, Nigeria, 1987
Dr. Carl Osborne & Dr. Jody Lulich
My research interests focus on the epidemiology of urolithiasis in domestic animals. As a team we have worked on the epidemiology of urolithiasis in dogs, cats and ferrets. Now we are working on the epidemiology of urolithiasis in goats. We plan to extend this study to sheep, cows, horses, pigs, rabbits and guinea pigs. Knowledge of these risk factors may facilitate development of surveillance strategies that result in earlier detection of urolithiasis in domestic animals as well as help in the design of effective diagnostic, therapeutic and prevention of this condition.
Osborne CA, Albasan H, Lulich JP, Nwaokorie EE et al. Quantitative Analysis of 4468 Uroliths Retrieved from Farm Animals, Exotic Species, and Wildlife Submitted to the Minnesota Urolith Center: 1981 to 2007. Vet Clin North Am Small Anim Pact 2009; Vol.39, Issue 1: 65-78.
Nwaokorie EE, Osborne CA, Lulich JP, Albasan H et al. Epidemiology of struvite uroliths in ferrets 272 cases (1981-2007). J Am Vet Med Assoc 2011; 339: 1319-1324.
Osborne CA, Ulrich LK, Nwaokorie E E. Reactive versus empathic listening: what is the difference? J Am Vet Med Assoc 2013; 242: 460-462.
Nwaokorie EE, Osborne CA, Lulich JP, Albasan H et al. Epidemiological evaluation of cystine urolithiasis in domestic ferrets (Mustela putorius furo):70 cases (1992-2009) J Am Vet Med Assoc 2013; 242: 1099-1103.
D.V.M., Universidad de la Republica Oriental del Uruguay. Facultad de Veterinaria, 2009
Dr. Andres Perez
The goal of my MsSc thesis is to characterize the spatial and temporal dynamics of bovine tuberculosis (BT), and to assess the nature and extent of the association between epidemiological factors and BT outbreaks in Uruguay. Results will contribute to design and implement risk-based surveillance strategies for BT in Uruguay and the United States.
Ribeiro Roos, Luiza
D.V.M., Universidade de Brasilia, 2013
Dr. Maria Pieters
I'm interested in the infection dynamics of Mycoplasmas that affect the swine species. My current research focus on understanding the transmission patterns of Mycoplasma hyopneumoniae in order to develop a gilt acclimation protocol prior entering the breeding herd.
Roos L.R., Fano E., Payne B., Pieters M. ‘Optimal ratio for successful exposure of gilts to Mycoplasma hyopneumoniae’. Poster presentation, CVM Points of Pride Research Day, University of Minnesota, Saint Paul, Minnesota, USA. 2014
(To be held in Feb 2015) Roos L.R., Pieters M.' Preliminary results on a protocol for Mycoplasma hyopneumoniae gilt acclimation'. Minnesota Veterinary Medical Association Annual Meeting. Minneapolis, Minnesota, USA.
M.S., Pathogenic Organisms, Fudan University, 2005
B.S., Forensic Medicine, Fudan University, 2002
Dr. Yuying Liang
I am working on the arenaviruses family, with a research focus on the interaction between viral proteins and host, and the pathogencity of the different GPC mutants of PICV.
Sharafeldin, Tamer Ahmed
M.V.Sc., Zagazig University, Egypt, 2008
B.V.Sc, Zagazig University, Egypt, 2004
Dr. Sagar Goyal & Dr. Rob Porter
I am studying pathogenesis and immunology of reovirus arthritis in turkeys. The virus has been isolated from tendons of 15 weeks old tom turkeys with lameness and ruptured tendons in 2011. We experimentally could reproduce the disease in turkeys. The virus induced tenosynovitis in gastrocnemius tendon sheath at 4 weeks post inoculation with no lameness. Lameness started in experimentally infected birds at 7 weeks post inoculation and % of lameness increased at 15 weeks post inoculation with tendon rupture in some turkeys. Further work is going on to study the pathogenesis of the virus and tissue spread using S4 gene copy number determination by rRT-PCR and immunohistochemisrty. Cytokine profile will be studied also in the infected birds. In addition, gastrocnemius tendon biomechanics will be evaluated in infected birds and electron microscopy will be used to report ultra structural changes in infected birds' tendons.
Mor, S.K., Sharafeldin, T.A., Abin, M., Kromm, M., Porter, R.E., Goyal, S.M. and Patnayak, D.P. (2013) The occurrence of enteric viruses in Light Turkey Syndrome. Avian Patholology, 42, 497-501
Mor, S.K., Sharafeldin, T.A., Porter, R.E., Ziegler, A., Patnayak, D.P. and Goyal, S.M. (2013) Isolation and characterization of a turkey arthritis reovirus. Avian Diseases, 57, 97-103
Mostafa Y. Abdel-Glil, Sunil Kumar Mor, Tamer A. Sharafeldin, Rob Porter, and Sagar M. Goyal. Detection and characterization of Newcastle disease virus in formalin-fixed, paraffin-embedded tissues from commercial broilers in Egypt. Avian Diseases (2014). in press
Sharafeldin T. A., Mor S. K., Bekele A. Z., Verma, H., Goyal S. M and Porter R. E. The role of reoviruses in turkey arthritis. Avian Pathology (2014). Submitted
Tamer A. Sharafeldin, Sunil K. Mor, Harsha Verma, Aschalew Z. Bekele, Sagar M. Goyal and Robert E. Porterthogenicity of Turkey Arthritis Reoviruse in Chickens, Under review
Tamer A. Sharafeldin, Sunil K. Mor, Harsha Verma, Aschalew Z. Bekele, Sally Noll, Sagar M .Goyal and Robert E. Porter, Long term pathogenicity of turkey arthritisreovirus (TARV) in turkeys, Under review
Role of enteric viruses in light turkey syndrome (Oral presentation) in 62nd North Central Avian Disease Conference, Saint Paul, MN 2012
Comparative pathogenecity of turkey arthritis reovirus in turkeys (Oral presentation) in 63rd North Central Avian Disease Conference, Saint Paul, MN 2013
Comparative pathogenecity of turkey arthritis reovirus in turkeys (Poster presentation) in AAAP/AVMA annual conference, Chicago, IL 2013
Long term pathogenicity of turkey arthritis reovirus in turkeys, North Central Avian Disease Conference (NCADC), 2014
Pathogenesis of turkey arthritis reovirus, western conference of poultry diseases (WCPD), Puerto Vallarta, Mexico, 2014
Partnership and Ownership (ParOwn) 6 months fellowship to Veterinary Diagnostic Laboratory, University of Minnesota (2009)
North Central Avian Disease Conference (NCADC) student travel award, 2014
VMED graduate student travel award, spring, 2014, University of Minnesota
B.S., Biological Sciences, Federal University of Uberlandia, Brazil
Dr. Srinand Sreevatsan
My master’s project is to understand the metabolic networks of Mycobacterium avium subsp. paratuberculosis (MAP) in order to sharpen our understanding of MAP virulence and to devise optical vaccines and cultivation media to enhance its diagnosis.
Yaya Wang, Iftach Shaked, Stephanie M. Stanford, Wenbo Zhou, Julie M. Curtsinger, Zbigniew Mikulski, Zachary R. Shaheen, Genhong Cheng, Kristy Sawatzke, Amanda M. Campbell, Jennifer L. Auger, Hatice Bilgic, Fernanda M. Shoyama, David O. Schmeling, Henry H. Balfour Jr., Kiminori Hasegawa, Andrew C. Chan, John A. Corbett, Bryce A. Binstadt, Matthew F. Mescher, Klaus Ley, Nunzio Bottini, & Erik J. Peterson. The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity. Immunity, 2013 39(1), 111–122
Silva, Alexandre L. Neves ; Adade, Camila M. ; Shoyama, Fernanda M. ; Neto, Cecílio Purcino S. ; Souto-Padrón, T. C. B. S. ; de Almeida, Mauro V. ; Rezende, Carlos A. de MagalhÃ es ; Silva, Claudio V. ; Souza, Maria A. . In vitro leishmanicidal activity of N-dodecyl-1,2-ethanediamine. Biomedicine & Pharmacotherapy, v. 66, p. 180-186, 2012.
MnDRIVE Global Food Supply Initiative Fellowship, 2014-2015
B.S., Animal Science, University of Wisconsin-River Falls
Dr. Gerard Cramer & Dr. Sandra Godden
My research interests are in the dairy industry, specifically animal welfare and the hoof trimming process. This area is currently lacking strong scientific evidence for its efficacy. I am going to use random controlled trials and observational studies to investigate the effect, timing and proper technique of hoof trimming for dairy cattle.
Stoddard G. C. and K. D. Vogel. 2013. Cull with care. Hoard’s Dairyman. 158(18):679.
Stoddard G. C. and K. D. Vogel. 2013. From farm to harvest: beef quality begins with smart culling. Hoard’s Dairyman. 158(20):745.
Stoddard G. C. and K. D. Vogel. 2013. Cull With Care: When Culling is Not an Option. Hoard’s Dairyman. 158(21):804.
RK Anderson Fellowship, 2014
University of Wisconsin River Falls Rochelle Junkman Seymour Award, 2014
University of Wisconsin River Falls Summa Cum Laude, 2014
M.S., Preventive Medicine, Kangwon National University, Republic of Korea, 2012
D.V.M., Kangwon National University, Republic of Korea, 2010
Dr. Peter Davies
My research focuses on the prevalence investigation of Staphylococcus aureus including methicillin resistant Staphylococcus aureus (MRSA) in pig and swine veterinarian in U.S to evaluate colonization and infection patterns. We also have determined the predominant S.aureus genetic types using spa typing and MLST methods from isolates to understand the current distribution of this pathogen in pig industry.
Office of Graduate Programs Travel Award, Fall 2013
D.V.M., University of Saskatchewan, 2011
Dr. Troy Trumble
My area of research is investigating intra-articular therapies for management of osteoarthritis in the horse, through use of measuring indirect immunologic biomarkers in synovial fluid. Specifically, my current investigation is focused on the intra-articular medication: autologous conditioned serum (more commonly known as 'IRAP').
2013 recipient of the American College of Veterinary Surgeons Foundation - Surgeon In-Training Grant, entitled: "Concentrations of Cytokines and Matrix Metalloproteinases in Serum and Synovial Fluid Following Injection of Autologous Conditioned Serum into Equine Osteoarthritic Distal Inter-Phalangeal Joints."
D.V.M., Universidade Paulista, Brazil, 2004
Dr. Molly McCue
A correlation between the gray coat color and melanoma development has long been recognized with up to 80% of gray horses older than 15 years developing melanoma. Both graying and melanoma formation have been linked to a duplication in the Syntaxin 17 (STX17) gene, with the STX17 genotype affecting melanoma grade and severity in the Lipizzaner breed. An ASIP mutation, responsible for the bay/black coat color modifies melanoma risk in gray horses, with increased melanoma severity potentially due to an increase in MC1R pathway signaling. We have identified a population of gray Quarter Horses (QH) that appear to have a decreased melanoma risk. The objective of our study is to determine if the decreased incidence of melanoma in gray QH is related to decreased MC1R signaling resulting from the MC1R chestnut coat color allele. Identification of genetic factors that result in altered melanoma susceptibility will allow for more accurate assessment of prognosis and metastasis risk in horses with dermal melanomas.
Genetic determinants of melanoma susceptibility in gray horses, 2012 ACVIM Forum, New Orleans, LA, May 31, 2012.
William and Deanna Pritchard Fellowship, 2013
CVM Research Day Best Poster Award, 2013
D.V.M., University of Minnesota, 2011
B.S., University of Minnesota, 2008
Dr. Bob Morrison
My research focus is on the epidemiology of PRRS virus in swine herds with an interest in risk factors of infection including spatial and temporal analysis and mapping. We have worked to develop a database of 10 production companies, of approximately 300 sow herds, representing nearly 1,000,000 sows in 14 states. Using this database, we have designed field trials to understand the effect of PRRS vaccination on the frequency and variety of PRRS viruses detected in air within a region. I have also conducted several trials on the role of oral vitamin D3 supplementation in suckling and post-weaned pigs and the response in performance and immune function.
Tousignant S., Henry S., Rovira A., Morrison R. Effect of oral vitamin D3 supplementation on growth and serum 25-hydroxy vitamin D levels in pigs up to 7 weeks of age (under review).
Tousignant S., Morrison R. National PRRS project provides infection rate. National Hog Farmer Online, July 2012.
Tousignant S., Morrison R. Are you ready for PRRS season? Pork Magazine, November 2012.
Tousignant S., Morrison R. (2010). A survey of anaerobic digesters on swine farms (student poster session). American Association of Swine Veterinarians, Omaha, Nebraska.
Tousignant S., Henry S., Morrison R. (2011). A field trial to determine effect of vitamin D oral supplementation (oral presentation). Allen D. Leman Swine Conference, St. Paul, MN.
Tousignant S., Goede D., Morrison R. (2012). Identifying areas at high risk for epidemic spread of PRRS virus (oral presentation). Allen D. Leman Swine Conference, St. Paul, MN.
Tousignant S., Morrison R. (2012). Sow herd PRRS incidence/prevalence project (oral presentation). Allen D. Leman Swine Conference, St. Paul, MN.
Tousignant S., Rovira A., Morrison R. (2012). Reproduction of Peri Weaning Failure to Thrive Syndrome in weaned pigs and effect of supplemental vitamin D (oral presentation). Allen D. Leman Swine Conference, St. Paul, MN.
Morrison R., Tousignant S. (co-investigator). Impact of pig farm density on incidence of PRRS in a cohort of sow herds. National Pork Board. Funding begins October 2012.
Morrison R., Tousignant S. (co-investigator). A pilot study to determine risk of PRRS infection from 3 years of retrospective data as a means of predicting future outbreaks in a large sample of US sow herds. College of Veterinary Medicine, Population systems signature series grant. Funding begins October 2012.
National Needs Fellowship in Food Animal Biosecurity: Infectious Disease Biology. Fellowship begins January 2013.
M.S., Pathobiology, Pennsylvania State University, 2012
BVSc. & A.H., Anand Agricultural University, India, 2009
Dr. Subbaya Subramanian & Dr. David Largaespada
Osteosarcoma is the most common primary bone malignancy affecting children, adolescents and young adults. Additionally, osteosarcoma is commonly found in canines, with approximately 10,000 new cases each year. The complex biology of osteosarcoma and tumor heterogeneity makes it challenging to identify effective new gene targets and therapeutic agents. We have found that a unifying feature of osteosarcoma is the overexpression of miR-17-92 microRNAs. We have deciphered that deregulation of 14q32miR/cMYC network leads to overexpression of miR-17-92 in osteosarcoma. This deregulation is associated with poorer outcomes in osteosarcoma and is preserved in naturally occurring canine osteosarcoma suggesting a conserved disease mechanism. Upregulation of miR-17-92 miRNAs contributes to osteosarcoma progression by targeting potential tumor suppressor osteosarcoma driver genes such as PTEN. Additionally, our studies show that the prodrug Minnelide inhibits cMYC expression and downregulates miR-17-92 miRNAs. Together, our data suggests that upregulation of miR-17-92 miRNAs contributes to osteosarcoma progression and Minnelide reduces tumor burden in osteosarcoma by inhibiting miR-17-92 expression.
Varshney Jyotika B., Very Katherine J., Williams Jen L., Hegarty John P., Stewart David B., Lumadue Jeanne, Venkitanarayanan Kumar, and Jayarao Bhushan M.. Foodborne Pathogens and Disease. October 2014, 11(10): 822-829. doi:10.1089/fpd.2014.1790.
Varshney, J.; Ooi, J.H.; Jayarao, B..M.; Istvan, A.; Fisher, J.; Smith, R.; Patterson, A.; Cantorna, M.T. White button mushrooms increase microbial diversity and accelerate the resolution of Citrobacter rodentium infection in mice. The Journal of Nutrition 143, no. 4 (2013): 526-532.
Varshney J, Subramanian S. “MicroRNAs in Cancer.” Current Science. 2013
Varshney J and Subramanian S. “MicroRNA gene regulation in osteosarcoma, Osteosarcoma: Symptoms, Diagnosis and Treatment Options.” Nova Publications. Book chapter.
Platform presentation: cMYC transactivated miR-17-92 cluster plays a crucial role in osteosarcoma progression, 2013 International Conference on Advances in Canine and Feline Genomics and Inherited Diseases. Broad Institute at MIT Cambridge, USA
Vaughn Larson Award. CVM, University of Minnesota, 2014
CGE Travel Grant, August 2014
CVM Research Day Best Poster Award, University of Minnesota, Minneapolis, MN 2013
Anand Agricultural University: University topper and Gold Medalist (2009):
- Highest GPA in Clinical Sciences (Surgery, Radiology, and Theriogenology)
- Highest GPA in Para-clinical Sciences (Pathology, Microbiology and Parasitology)
M.S., Pharmacology, University of Minnesota, 2013
M.S., Toxicology, University of Michigan, 2008
M.E., Chemical Engineering, Tsinghua University, 2006
D.V.M., Shandong Agricultural University, 2001
Dr. Sabita Roy
Alteration in gut microbiome has been shown to contribute to bowel dysfunction and gut barrier disruption. We have recently demonstrated that morphine treatment results in significant disruption in gut barrier function leading to increased translocation of gut commensal bacteria. Gut microbiome plays an important role in maintaining gut homeostasis. However, the effect of morphine on gut microbiome has not been investigated. Citrobacter rodentium is a natural mouse pathogen that models intestinal infection by enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) in humans and causes attaching and effacing (A/E) lesions and colonic hyperplasia. My research focuses on the effects of morphine treatment on host mucosal immunity, gut microbiota, and bacterial virulence in a Citrobacter rodentium-mouse model. My research will expand understanding of effects of morphine on the microbiome-neuroimmune axis, and of its role in the gut homeostasis.
Zhan Y, Chen PJ, Sadler WD, Wang F, Poe SA, Eaton KA, Nunez G, Chen G. Gut Microbiota Protects against Gastrointestinal Tumorigenesis Caused by Epithelial Injury. Cancer Research. 2013, 73(24):7199-210.
He X, Lyons DM, Toffaletti DL, Wang F, Qiu Y, Davis MJ, Meister DL, Dayrit JK, Lee A, Osterholzer JJ, Perfect JR, Olszewski MA. Virulence Factors Identified by Cryptococcus neoformans Mutant Screen Differentially Modulate Lung Immune Responses and Brain Dissemination. Am J Pathol. 2012, 181(4):1356-1366
Qiu Y, Zeltzer S, Zhang Y, Wang F, Chen GH, Dayrit J, Murdock BJ, Bhan U, Toews GB, Osterholzer JJ, Standiford TJ, Olszewski MA. Early Induction of CCL7 Downstream of TLR9 Signaling Promotes the Development of Robust Immunity to Cryptococcal Infection. Journal of Immunology. 2012, 188(8):3940-3948
Chen GY, Liu M, Wang F, Bertin J, Nunez G. A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. Journal of Immunology. 2011, 186(12):7187-7194.
Zhang Y, Wang F, Bhan U, Huffnagle GB, Toews GB, Standiford TJ, Olszewski MA. TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans infected lungs. Am J of Pathol. 2010, 177(2):754-765. (co-first author)
Zhang Y, Wang F, Tompkins KC, McNamara A, Jain AV, Moore BB, Toews GB, Huffnagle GB, Olszewski MA. Robust Th1- and Th17-Immunity Supports Pulmonary Clearance but Cannot Prevent Systemic Dissemination of Highly Virulent Cryptococcus neoformans H99. Am J of Pathol. 2009, 175(6):2489-2500.
Wang F, Miao C, Liu Z. Effect of Electric Field on Cell Growth, Permeability, and Extracellular Enzymatic Activity of Phanerochaete chrysosporium, Chinese Journal of Process Engineering. 2007, 07(02): 86-90.
Wang F, Diao Y. Isolation and Identification of Avian Escherichia coli from Chickens in Partial Regions of Shandong Province, Shandong Journal of Animal Science and Veterinary Medicine. 2002, 15(1):1-2.
Wang F, Sindberg G, Banerjee S, Ma J, Li D, Johnson T, Roy S. Morphine treatment shifts the mouse colonic microbiome and promotes systemic dissemination of Citrobacter rodentium. 20th Scientific Conference of Society on NeuroImmune Pharmacology (SNIP), New Orleans, Louisiana, March 26-29, 2014
Wang F, Meng J, Roy S. Morphine Treatment Increases Citrobacter rodentium Virulence and Disrupts Infection Induced IL17a Immune Response in Mice. The 16th International Congress of Mucosal Immunology (ICMI 2013), Vancouver, BC, Canada, July 2013
Liu M, Wang F, Shaw M, Nunez G, Chen GY. Nod1 functions in T cells to suppress inflammation-associated colorectal cancer. Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research, Chicago, IL. Mar 31-Apr 4, 2012. Cancer Res 2012;72(8 Suppl):Abstract nr 532. doi:1538-7445.AM2012-532
Zhang Y, Wang F, Hardison SE, Love CK, Chen G, Osterholzer JJ, Wormley FL, Toews GB, Adler A, Williamson PR, Huffnagle GB, Olszewski, MA. Cryptococcal virulence factor Ssa1 interferes with the innate host responses by inducing the alternative activation of macrophages during the afferent phase of the immune response in the infected lungs. The General Meeting of the American Society for Microbiology, San Diego, May 2010
Wang F, Olszewski MA, Zhang Y, Osterholzer JJ, Chen G, Zeltzer S, Huffnagle GB, Toews GB Bhan U, Standiford TJ. The Role of Toll-Like Receptor 9 (TLR9) in Anticryptococcal Host Defenses. The General Meeting of the American Society for Microbiology, Philadelphia, May 2009
Early Career Investigator Travel Award, Society on NeuroImmune Pharmacology (SNIP), 2014
Office of Graduate Programs Enhanced Learning Travel Award, 2013
M.Sc., Molecular Biology & Biotechnology, Makerere University, 2013
D.V.M., Makerere University, 2005
Dr. Srinand Sreevatsan
My research will involve the comprehensive tracking of biomarkers for diagnostics and One Health. I will be working on zoonotic TB in humans and animals as well as testing the efficacy of a novel diagnostic tool on samples from these populations (wildlife, cattle and humans).
ICI3D Clinic on Dynamical Approaches to Infectious Disease Data travel award, 2014
Fogarty Global Health Fellowship, 2012-2013