Meet the VMED Students

Graduate Students in Veterinary Medicine

MS and PhD students in VMED are engaged in research related to animal and human health and welfare. Our students study infectious and zoonotic diseases, the development of novel treatments for cancer and other diseases, genetic research and therapies, virology and bacteriology, and ecosystem and wildlife health, among other areas of research.

    Carmen Alonso VMED

    Alonso, Carmen

    alons015@umn.edu

    Degrees
    M.S. Veterinary Medicine, University of Minnesota, 2012
    D.V.M., Universidad Complutense Madrid, 2003

    Advisers
    Dr. Peter Davies & Dr. Montserrat Torremorell

    Research
    My research focuses on the characterization of particle size ranges that are associated with airborne viruses in swine aerosols, under controlled and field conditions, to better understand the mechanisms of disease transmission within and between farms

    Publications
    Alonso, C; Goede, DP; Morrison. RB; Davies, PR; Marthaler, DG; Torremorell, M; Evidence of long-distance transport and infectivity of airborne porcine epidemic diarrhea virus. Vet Res. (2014)July 14, 45(1):73

    Alonso, C; Davies, P.R; Polson, D. D; Dee, S. A; Lazarus, W. F. Financial implications of air filtration systems for preventing PRRSV infection in large sow herds. Prev Vet Med. (2013) Sep 1;111(3-4):268-77

    Alonso, C; Murtaugh, M. P; Dee, S. A; Davies, P.R .Epidemiological study of air filtration systems for preventing for preventing PRRSV infection in large sow herds. Prev Vet Med. (2013) Oct 1;112(1-2):109-17

    Alonso C, Otake S, Davies P, Dee S. An evaluation of interventions for reducing the risk of PRRSV introduction to filtered farms via retrograde air movement through idle fans. Vet. Microbiol. (2012), 157, 3-4, 304-10

    Presentations (selected)
    Alonso C, Raynor P, Davies P, Torremorell M. Effect of the electrostatic particle ionization technology on PRRSV and influenza aerosols under experimental conditions. American Association of Swine Veterinarians Conference. Dallas, Texas, USA; 2014

    Alonso C, Raynor P, Davies P, Torremorell M. Electrostatic Particle Ionization (EPI) system as a means to decrease artificially generated PRRSV aerosols. International PRRSV Symposium. Chicago, Illinois, USA; 2013

    Alonso C, Raynor P, Davies P, Torremorell M. Preliminary data on the effect of electrostatic particle ionization system on decreasing  infectious aerosols. Allen D. Leman Swine Conference-Carlos Pijoan SDEC Symposium: Scientific Challenges and Approaches to Regional Disease Control. St. Paul, Minnesota, USA; 2013

    Alonso C, Dee S, Polson D, Davies P. Phylogenetic evaluation of historic PRRSV isolates from air filtered sow herds in North America. American Association of Swine Veterinarians Conference. San Diego, California, USA; p. 65, 2013 

    Alonso C, Dee S, Davies P. Payback period for air filtration systems in large sow herds targeting the prevention of PRRSV entry- Partial budget analysis. Allen D. Leman Swine Conference-Carlos Pijoan SDEC Symposium: Managing filtered farms. St. Paul, Minnesota, USA; 2012

    Alonso C, Dee S, Davies P. Epidemiological evaluation of air filtration in large sow herds in North America. International Symposium on Veterinary Epidemiology and Economics-ISVEE. Maastricht, Netherlands; p. 86, 2012

    Alonso C, Dee S, Davies P, Lazarus W. Economic evaluation of air filtration systems for PRRSV in large sow herds in a swine dense region in North America. International Pig Veterinary Society Congress-IPVS. Jeju Island, South Korea; Volume 2, p. 994, 2012

    Awards
    Carlos Pijoan Scholarship. CVM, University of Minnesota (January 2014)

    University of Minnesota Distinguished Master's Thesis Award. College of Veterinary Medicine University of Minnesota (October 2013)

    OGP Graduate Education Travel Award.  College of Veterinary Medicine University of Minnesota (April 2013)

    Awarded poster. Allen D. Leman Swine Conference. Economic evaluation of air filtration systems for PRRSV in large sow herds in North America (September 2012)

    1st Prize Oral. Biosafety and Biosecurity Award from the Animal Health Institute-Joseph J. Garbarino Foundation. Conference of Research Workers in Animal Diseases 2011. An evaluation of interventions for reducing the risk of PRRSV introduction to filtered farms via retrograde air movement through idle fans (back-drafting) (December 2011) 


     

    Sam Beeson VMED

    Beeson, Samantha

    beeso018@umn.edu

    Degree
    B.S., Animal Science, University of Minnesota, 2012

    Adviser
    Dr. Molly McCue

    Irene Bueno VMED

    Bueno Padilla, Irene

    bueno004@umn.edu

    Degrees
    M.P.H. University of Minnesota, 2013
    D.V.M., University of Cordoba, Spain, 2007

    Adviser
    Dr. Srinand Sreevatsan 

    Research
    I am interested in ecosystem health research-specifically the disease dynamics at the interface between wildlife, humans and the environment.

    Publications

    Bueno Padilla, I; Klauss, G; Gardiner, C.H; Wuenschmann, A. Disseminated mite infection with ocular involvement in a juvenile bald eagle (Haliaeetus leucocephalus). Veter. Ophthalmol. J. 15(4): 271-275. 2012.

    Rutkiewicz, J; Nam, D; Cooley, T; Neumann, K; Bueno Padilla, I; Route, W; Strom, S; Basu, N. ‘Mercury exposure and neurochemical impacts in bald eagles across several Great Lakes states’. Ecotoxicol. July 2011.

    Bueno-Padilla, I; Arent, L; Ponder, J. ‘Tips for Raptor Bandaging’. Exotic DVM, Volume 12, Issue 3. 2010.

    Willette, M; Ponder, J; Cruz, L; Arent L; Bueno, I; Nicolas, O; Redig,P. ‘Management of Select Bacterial and Parasitic Conditions of Raptors’. Veter. Clinics N. Amer.- Exotic Animal Practice. September 2009.

    Presentations (selected)

    Bueno, I.; Redig, PT.; Ponder, J.; Willette, M. Bullets and bald eagles: Developing a model for dealing with conflicts in ecosystem health. The Wildlife Society, Milwaukee, WI. October 6th 2013.

    Bueno-Padilla, I.; Redig, P.T.; Willette, M.; Ponder, J. Socio-economical and political aspects of spent lead ammunition. Wildlife Disease Association. Knoxville, Tennessee. July 2013.

    Bueno-Padilla, I.; Smith, K.; Travis, D.; Machalaba, C.; Karesh, W.B. A tool to assess the public health risks of wildlife importation into the United States: The case of rodents from Latin America. Wildlife Disease Association. Knoxville, Tennessee. July 2013.

    Bueno, I. Treatment of lead intoxication in raptors. National Wildlife Rehabilitation Association Symposium. Baton Rouge, LA. March 2012.

    Bueno, I. Raptor Tissue Sampling and Necropsy. Raptor Research Foundation Conference. Duluth, Minnesota. October 2011.

     

    Rachael Ceballos VMED

    Ceballos, Rachael

    cebal016@umn.edu

    Degree
    B.S., Biochemistry and Animal Science, Berry College

    Adviser
    Dr. Carol Cardona

    Research
    My research interest is viral disease pathogenesis with a focus on influenza A viruses. My current research is directed toward the stability of the viral envelope under varying environmental conditions. I am interested in the viral and host factors that determine transmissibility of influenza A viruses in poultry species.

    Awards
    NIFA Fellowship in Food Animal Biosecurity: Infectious Disease Ecology, 2013-2016
     

    Fabian Chamba VMED

    Chamba, Fabian

    chamb376@umn.edu

    Degree
    D.V.M., Universidad Central de Ecuador

    Advisers
    Dr. Srinand Sreevatsan & Dr. Montse Torremorell

    Research
    My research interest seeks to understand the effect of control measures like vaccination over genetic and antigenic evolution and variation of Influenza A virus in pig populations, especially in breeding herds.

     

    Maria Jose Clavijo VMED

    Clavijo, Maria Jose

    clavi005@umn.edu

    Degree
    D.V.M - Universidad Central de Venezuela 2009

    Advisers
    Dr. Albert Rovira & Dr. Robert Morrison

    Research
    The focus of my research is gaining knowledge on the epidemiology of Mycoplasma hyorhinis by developing highly specific and sensitive diagnostic and genotyping tools that would aid in the establishment of proper prevention and control measures for this pathogen.

    Publications
    Clavijo M.J., Oliveira S. (2009). Development of a quantitative real-time PCR for the detection of Actinobacillus suis in clinical samples. Proceedings of the 40th Annual Meeting of the American Association of Swine Veterinarians, Dallas, Texas.

    Clavijo M.J., Oliveira S. (2008). Molecular characterization of Streptococcus suis isolates recovered from U.S. swine herds – unraveling the human link. Proceedings of the 39th Annual Meeting of the American Association of Swine Veterinarians, San Diego, California.

    Presentations
    Clavijo MJ, Rovira A, Murray D, Oliveira S (2011) Mycoplasma hyorhinis: Epidemiology of infection in endemically infected farms. Proceedings of the 40th Annual Meeting of the American Association of Swine Veterinarians, Phoenix, Arizona.

    Clavijo MJ, L Bruner, S Olson, EL Rosey, D Pearce, A Rovira (2012) Dynamics of Mycoplasma hyorhinis infection in clinically affected swine herds. Proceedings of the 22nd International Pig Veterinary Society Congress, Jeju, South Korea.

    Clavijo MJ, L Bruner, S Olson, EL Rosey, D Pearce, A Rovira (2012) Dynamics of Mycoplasma hyorhinis infection in clinically affected swine herds. Proceedings of the XLVII Congreso de la Asociacion Mexicana de Especialistas en Cerdos, Guadalajara, Mexico.

    Clavijo MJ, A Rovira (2012) Mycoplasma hyorhinis: Que provoca y como buscarlo? In: Proceedings of 15 Foro Porcino Pfizer, Barcelona, Spain. October 1st and 2nd.

    Clavijo MJ, (2013). Insight into Mycoplasma hyorhinis. Pork community webcast Pfizer Animal Health. January 18th 2013.

    Clavijo MJ (2013). Actualidades sobre M. hyorhinis y M. hyosynoviae. Boehringer Ingelheim Vetmedica “Se habla en español”. February 25th 2013.

    Grants
    Co-investigator: Characterization of Mycoplasma hyorhinis transmission and spread within endemically infected populations National Pork Board. Funded $49,685 May 2010.

    Principal investigator: Emerging and Zoonotic Diseases Signature Program Mentored Research. Funded $7,000 August 2011.

    Co-investigator: Characterization of the genetic diversity of Mycoplasma hyorhinis field isolates by multiple locus variable number of tandem repeats analysis (MLVA) and multi-locus sequence typing (MLST). National Pork Board. Funded $35,000 May 2012.

    Co-investigaotr: Comparison of different times of Draxxin administration for the control of Mycoplasma hyorhinis disease. Pfizer animal Health Draxxin 2012 call for abstracts. Funded $25,273 December 2012.

    Awards
    Veterinary Student of the year 2006-2007. Universidad Central de Venezuela.

    Scientific Merit 2008. Facultad de Ciencias Veterinarias - Universidad Central de Venezuela.

    Student session oral presentation: Scholarship awarded by the American Association of Swine Veterinarians at 39th Annual Meeting 2008 - Student session oral presentation.

    Student session oral presentation: Scholarship awarded by the American Association of Swine Veterinarians at the 40th Annual Meeting 2008.

    Carlos Pijoan Fellowship at the College of Veterinary Medicine of the University of Minnesota Graduate Program, Fall 2010.

    AAVLD-sponsored Trainee Travel Award 2011. AAVLD annual meeting.

    First place in poster competition. Research Days 2012, College of Veterinary Medicine, University of Minnesota. Poster entitled: Dynamics of Mycoplasma hyorhinis infection in two commercial swine herds.

     

    Elizabeth Coppelman VMED

    Coppelman, Elizabeth

    coppe017@umn.edu

    Degrees
    D.V.M., The Ohio State University, 2013
    B.S., Animal Biology, University of Florida, 2009

    Adviser
    Dr. Troy Trumble

    Andres Diaz VMED

    Diaz, Carlos Andres

    diazj002@umn.edu

    Degrees
    M.S., National University of Colombia, 2010
    D.V.M., National University of Colombia, 2005

    Adviser
    Dr. Montserrat Torremorell

    Research
    My research is focused on the diversity and evolution of Influenza A viruses in pig populations. Influenza A is a main cause of respiratory disease in pigs and a public health threat. I use next-generation sequencing technologies to reconstruct the viral population and understand the genetic factors that allow the virus to persist in swine populations for prolonged periods of time.

    Publications
    Diaz A. Enomoto S. Romagosa A. Sreevatsan S. Nelson M. Culhane M. Torremorell M. Genome plasticity of a triple reassortant H1N1 influenza A virus during infection of vaccinated pigs. Submitted for publication.

    Diaz A. Allerson M. Culhane M. Sreevatsan S. Torremorell M. Antigenic drift of H1N1 influenza virus in pig with and without passive immunity. Influenza and Other Respir Viruses 2013 dec: 7 Suppl 4:52-60 doi: 10.1111/irv.12190.

    Torremorell M, Allerson M, Corzo C, Diaz A, Gramer M. Transmission of influenza A virus in pigs. Transbound Emerg Dis. 2012; 59:68-84 .
    Diaz A. Rodriguez N. Vera V. Ramirez G. Casas G. Mogollon D. Characterization of pig farms in the main swine producing regions of Colombia. Rev Colomb Cienc Pecu 2011;24:131-144

    Diaz A. Jaime J. Vera V. Rodriguez N. Casas GA. Mogollon JD. Postweaning multisystemic wasting syndrome: epidemiological issues. Rev Med Vet  Zoot
    2008; 55:100-114

    Presentations (selected)
    Diaz A. Corzo C. Culhane M. Sreevatsan S. Torremorell. M. Co-circulation of influenza A viruses in swine populations. Allen D. Leman Swine Conference. Saint Paul,MN, USA 2014

    Diaz A. Torremorel M. Culhane M. Sreevatsan S. Complete genome characterization of influenza A virus in sow herds. MISM Influenza workshop. Fogarty International Center. NIH. Bethesda, MD. 2014

    Diaz A. Swine Influenza A virus. V national Symposium on virology. I Latin-American congress on virology. Pontificia Universidad Javeriana Bogota, Colombia 2013.

    Diaz A. S. Enomoto. Corzo C. Culhane M. Sreevatsan S. Torremorell M. Influenza A virus infection and diversity in commercial pig herds. AASV Meeting Dallas, TX 2014

    Diaz A. Enomoto S. Culhane M. Sreevatsan S. Torremorell M. Use of NGS to study within-host and between host diversity of influenza. USDA-NIH MISMS WORKSHOP. USDA NATIONAL Centers for animal health, Ames, IA 2013.

    Diaz A. Torremorell M. Influenza infection in the sow herd. Allen D. Leman Swine Conference.  Saint Paul MN, USA, 2012.

    Diaz A. Enomoto S. Sreevatsan S. Gramer M. Torremorell M. Full genome of swine influenza A virus subtype H1N1 using next generation sequencing. IPVS.  Jeju, South Korea 2012.

    Diaz A. Allerson M. Romagosa A. Gramer M. Sreevatsan S. Torremorell M. Influenza A virus diversity in immune pigs. CRWAD.  Chicago, IL 2011.

    Awards
    University of Minnesota Doctoral Dissertation Fellowship, 2014-2015

    Scholarship to attend the 19th summer institute in statistical Genetics. Module 9 and 14 University of Washington. 2014

    Scholarship to attend the 6th Summer Institute in Statistics and Modeling in Infectious Diseases. Module 14. University of Washington, 2014

    MnDrive student fellowship. MnDrive Global food supply initiative. 2013-2014

    CVM student travel award. University of Minnesota, 2014

    Veterinary medicine graduate students’ representative to the Program Advisory Committee, 2013

    Vaughn Larson Award. CVM, University of Minnesota, 2013

    Carlos Pijoan scholarship. CVM, University of Minnesota, 2012

    CVM student travel award. University of Minnesota, 2012

    Caldas scholarship. Colombian Government. 2010 

     

    Mythili Dileepan VMED

    Dileepan, Mythili

    dilee002@umn.edu

    Degrees
    M.Phil., Microbiology, University of Peradeniya, Sri Lanka, 2004
    B.V.Sc., University of Peradeniya, Sri Lanka, 1996

    Adviser
    Dr. Mathur Kannan

    Research
    Our lab is interested in the gene CD38 and its role in the pathogenesis of asthma. Previous studies from our lab showed that it is playing a role in hyper-responsiveness and inflammation, two of the cardinal features of asthma. Further it was shown that TNF-alpha induced CD38 expression is transcriptionally regulated by transcription factors NFK-B and AP-1 through MAPK pathway. My aims are to determine whether CD38 has a role in remodeling of airways, another feature of asthma and to find out whether CD38 is post-transcriptionally regulated by microRNAs.

    Publications
    Dileepan, M., Wijewardana, T.G., Horadagoda, N.U., Stipkovits, L., Varga, I and Dharmawardena, I.V.P. (2005). Evidence of Mycoplasma hyopneumoniae infection among slaughtered pigs in Sri Lanka. Tropical Animal Health and Production, 37(1): 21-23

    Dileepan.M., Wijewardana T.G., Horadagoda N.U. and Dharmawardena,I.V.P. (2002). Serological evidence for the presence of Mycoplasma hyopneumoniae in pigs in Sri Lanka. Sri Lanka Veterinary Journal. 49(1A): 1-4

    Dileepan, M., Wijewardana, T.G., Horadagoda, N.U. and Dharmawardana, I.V.P. (2001). An abattoir study on the aetio-pathology of lung lesions in pigs in Sri Lanka. Sri Lanka Veterinary Journal. 48(1A): 1-8

    Dileepan, M., Wijewardana, T.G., Horadagoda, N.U.and Townsend, M. Kirsty. (2001). Screening for toxigenic Pasteurella multocida among isolates recovered from tonsils and lungs of pigs. Sri Lanka Veterinary Journal. 48(1A): 17-19

     

    Sian Durward Akhurst VMED

    Durward-Akhurst, Sian

    durwa004@umn.edu

    Degree
    B.V.M.S., Glasgow University, 2009

    Adviser
    Dr. Stephanie Valberg

    Research
    My masters project is looking at horses with suspected immune mediated myositis, trying to identify the underlying cause and if there is a genetic link.

    Publications
    Durward-Akhurst SA, Mair TS, Boston R, Dunkel B. Comparison of two antimicrobial regimens on the prevalence of incisional infections after colic surgery. Vet Rec. 2013 Mar 16;172(11):287

    Naylor RJ, Durward-Akhurst SA. Use of the Accutrend Plus point-of-care monitor for blood triglyceride measurement in horses. Vet Rec. 2012 Mar 3;170(9):228.

     

    Dane Goede VMED

    Goede, Dane

    goed0051@umn.edu

    Degrees
    D.V.M., University of Minnesota, 2013
    B.S., Agricultural Biochemistry, Iowa State University, 2009

    Adviser
    Dr. Peter Davies

     

    Liz Goudie VMED

    Goudie, Elizabeth

    egoudied@umn.edu

    Degrees
    D.V.M., Ross University School of Veterinary Medicine, 2010
    B.S., Biology, Ursinus College, 2007

    Advisers
    Dr. Lynelle Graham & Dr. Alice Larson 

    Research
    My research focuses on pain as it relates to the brown adipose tissue in mice as well as tramadol pharmacokinetics in dogs.

    Michelle Goulart VMED

    Goulart, Michelle

    goula030@umn.edu

    Degrees
    Small Animal Surgical Residency, Universidade Federal de Uberlandia (Brazil), 2002-2003
    D.V.M., Universidade Federal de Uberlandia (Brazil), 2002

    Adviser
    Dr. Liz Pluhar

    Research
    My project is in clinical/translational research with a focus on cancer immunotherapy for treatment of malignant forms of brain tumors in dogs. We are currently working on novel therapies using autologous vaccines for induction and expansion of tumor-specific T cells and antibody responses, with the goal of improving the immune response against cancer cells to prevent recurrence and tumor progression.

    Publications
    Goulart MR, Pluhar GE, Ohlfest JR. Identification of myeloid derived suppressor cells in dogs with naturally occurring cancer. PLoS One 7:e33274, 2012.

    Pluhar GE, Grogan PT, Seiler C, Goulart M, Santacruz KS, Carlson C, Chen W, Olin MR, Lowenstein PR, Castro MG, Haines SJ, Ohlfest JR. Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy. Vaccine. 2010 April 26; 28(19):3371–78.

    Milken VMF, Freitas PMC, Eurides D, Silva FOCE, Mota FCD, Naves EA, Rezende RJ, Prieto LA, Melo MS, Goulart MR. Blockage of the jaw’s alveolar nerve with 0.5% ropivacaine in cats (Felis catus domesticus). Ciencia Rural. 2006, 36(2):550-54. ISSN 0103-8478.

    Mota FCD, Eurides D, Freitas PMC, Beletti ME, Goulart MR, Cunha LMF, Silva LAF, Fioravanti MCS. Use of the n-butyl cyanoacrylate adhesive and the polyglactin thread suture for corneal rhaphy in rabbit (Oryctolagus cunicullus). Journal of Veterinary Science. 2004 Sep,5(3):267-70.

    Freitas PMC, Eurides D, Mota FCD, Goulart MR, Naves EA, Melo MS, Lima CAP. The use of 0.3% bupivacaine for ischiatic nerve block in cats (Felis catus domesticus). Bioscience Journal, v.20, n.2, p.137-142, 2004.

    Freitas PMC, Eurides D, Mota FCD, Rezende RJ, Naves EA, Daleck CR, Melo MS, Goulart MR, Shimizu BJ. A comparative investigation of 0.75% bupivacaine and 0.75% ropivacaine for brachial plexus block in cats (Felis catus domesticus). Veterinaria Noticias, v.10, p.10-14, 2003.

    Presentations (selected)
    Goulart MR, Pluhar GE, Ohlfest JR. Identification of myeloid-derived suppressor cells in dogs. 98th Annual American Association of Immunologists Meeting, San Francisco CA. May 2011.

    Melo MS, Freitas PMC, Goulart MR, Pignaton W, Simoes JR, Pacca S. Effects of electroacupuncture on cats (Felis catus domesticus) anesthetized with isoflurane and submitted to ovariohysterectomy. 27th Brazilian Congress of Small Clinical Practice, Vitoria ES, v.1, p.20-20, 2006.

     

     

    Nitipong Homwong VMED

    Homwong, NItipong

    homwo001@umn.edu

    Degree
    D.V.M., Kasetsart University, Thailand, 2005

    Adviser
    Dr. John Deen

    Research
    My research is focused on creating Bayesian epidemiologic models to describe the within-herd transmission of swine Influenza A virus (IAV) with various conditions of the swine production system. The epidemiological model can serve as a tool to bridge unconnected pieces of information obtained from several places in order to provide insights into the underlying process of the IAV transmission. With the goal of developing an effective IAV surveillance scheme, Bayesian epidemiological models are proposed to describe and predict the IVA transmission within the swine herd conditional to piglet production batching, gilt replacement, and vaccination programs.

    Publications
    Kanjanapruthipong, J., N. Homwong and N. Buatong. 2010. Effects of prepartum roughage neutral detergent fiber levels on periparturient dry matter intake, metabolism, and lactation in heat-stressed dairy cows. J. Dairy Sci. (93): 2589-2597

    Chairattanasat, C., O. Songserm, N. Homwong and N. Paraksa. 2009. Effect of Crude Extract Product from Capsicum spp. Supplementation in Sow Dies on Passive Immunity in Piglets. Agriculture Sci. J. (1):65-72

    Rukkwamsuk, T., N. Homwong, W. Bumkhuntod, P. Rohitakanee and R. Sukcharoen. 2006. Negative Energy Balance in Periparturient Diary Cows Raised in Small-Holder Farms in Kamphaengsaen District, Nakhonpathom Province. Kasetsart J. (Nat. Sci.) 40:1000-1004.

    Presentations
    “A comparison of two lameness detection methods in sows: A search for the best method” 13th KVAC: International conference on Trans-boundary Disease; Impact on ASEAN One Health, June 7-8, 2012, Khon Kaen, Thailand.

    “Estimating hiding behavior for lameness in sows,” Conference of research workers in animal diseases (CRWAD) annual meeting, December 5th, 2011, Chicago, Illinois, USA

    “A simulation models for Influenza A virus dissemination in a growing pig herd with waning immunity” Points of Pride Research Day, October 2, 2013, Minnesota, USA

    “Using discriminant analysis to estimate sow culling-decision error rate and its posterior probability based on lameness and productivity” Points of Pride Research Day, October 10, 2012, Minnesota, USA

     

    Vachira Hunprasit VMED

    Hunprasit, Vachira

    hunpr001@umn.edu

    Degree
    D.V.M., Chulalongkorn University, Thailand, 2007

    Advisers
    Dr. Jody Lulich & Dr. Carl Osborne

    Research
    My research interest is focused on epidemiology of feline struvite urolithiasis, with emphasis on the association of the host, agent and environment factors to the development of struvite urolith in cats.

     

    Kaushi Kanankege VMED

    Kanankege, Kaushi

     

    Degrees
    M.S., Comparative Biomedical Science, University of Wisconsin-Madison, 2012
    Postgraduate Diploma, Applied Statistics, University of Peradeniya, Sri Lanka, 2010
    BVSc., University of Peradeniya, Sri Lanka, 2008

    Advisers
    Dr. Nicholas Phelps & Dr. Andres Perez

    Blank 2 CMB VMED

    Kemper, Ann

    amkemper@umn.edu

    Degrees
    D.V.M., Iowa State University, 2012
    B.S., Physics, Creighton University, 2006

    Adviser
    Dr. Molly McCue 

    Yonghyan Kim VMED

    Kim, Yonghyan

    kimx4078@umn.edu

    Degree
    D.V.M., Konkuk University, Republic of Korea, 2010

    Adviser
    Dr. Maxim Cheeran

    Yoojin Kim VMED

    Kim, Yoojin

    ymkim@umn.edu

    Degrees
    D.V.M., Konkuk University, Republic of Korea, 2008
    B.A., Mass Communication, Ewha Women's University, Republic of Korea, 2000

    Adviser
    Dr. Maxim Cheeran

    Amy Kinsley VMED

    Kinsley, Amy

    carr0603@umn.edu

    Degrees
    D.V.M., University of Minnesota, 2014
    B.S., Civil Engineering, University of Florida, 2006

    Advisers
    Dr. Meggan Craft & Dr. Andres Perez

    Whitney Knauer VMED

    Knauer, Whitney

    knaue020@umn.edu

    Degrees
    V.M.D., University of Pennsylvania, 2010
    B.S., Animal Science, University of Vermont, 2006

    Adviser
    Dr. Sandra Godden

    Research
    My research focuses on the health, well-being, and behavior of the group housed, pre-weaned dairy calf. Currently, we are utilizing precision dairy technologies to investigate the relationship between sensor derived feeding, activity and temperature data and health. The goal of this work is to improve our understanding of normal calf behavior and to improve surveillance techniques that will help producers to improve calf health, performance and well-being at both the individual animal and group level.

    Awards
    NIFA Fellowship in Food Animal Biosecurity: Infectious Disease Ecology, 2013-2016
    RK Anderson Fellowship, 2013

     

    Sunil Kumar VMED

    Kumar, Sunil

    kumars@umn.edu

    Degrees
    M.V.Sc., Chaudhary Charan Singh Haryana Agricultural University, India, 2009
    B.V.Sc. & A.H., Chaudhary Charan Singh Haryana Agricultural University, India, 2006

    Adviser
    Dr. Sagar Goyal

    Research
    I am completing a molecular characterization of a novel turkey arthritis reovirus (TARV) associated with lameness in turkeys. We are also developing a simple, sensitive and specific test for early diagnosis of the virus as well as to formulate control strategies including the development of autogenous vaccines (short term goal) and live or inactivated vaccines (long term goal).

    Publications
    S.K. Mor, M. Abin, G. Costa, A. Durrani, N. Jindal, S.M. Goyal and D.P. Patnayak (2011). Role of type 2 turkey astrovirus in poult enteritis syndrome. Poultry Sci 90:2747-52.

    S.K. Mor, G. Narang, N. Jindal, N.K. Mahajan, P.C. Sharma and N.K. Rakha (2010). Epidemiological studies on infectious bursal disease in broiler chickens in Haryana, India. International J Poultry Sci 9:395-400.

    S.C. Verma, N.K. Mahajan, and S.K. Mor (2007). Epidemiological survey of various diseases of cattle and buffaloes in Haryana. Haryana Veterinarian 46:38-40.

    Awards
    Graduate Student Award, 2013 North Central Avian Disease Conference. St. Paul, MN, 2013 "Characterization of a turkey arthritis reovirus"

     

    Fernando Leite VMED

    Lopes Leivas Leite, Fernando

     

    Degrees
    M.S., Veterinary Microbiology, Iowa State University, 2014
    D.V.M., Federal University of Santa Maria, Brazil, 2011

    Adviser
    Dr. Srinand Sreevatsan

    CVMGRAD_macedo image

    Macedo, Nubia

    maced004@umn.edu

    Degrees
    M.S., Federal University of Minas Gerais, Brazil, 2006.
    D.V.M., Federal University of Minas Gerais, Brazil, 2005.

    Advisers
    Dr. Montserrat Torremorell & Dr. Albert Rovira

    Research
    My research focuses on investigating the use of antibiotics as a factor that influences Haemophilus parasuis colonization and its effect on immune response development. Currently, my interest is in evaluating whether H. parasuis colonization may elicit an immune response that will be protective and whether this response may be impaired by the use of antibiotics.

    Publications
    N. Macedo, A. Rovira, S. Oliveira, M. Torremorell. Effect of enrofloxacin on the carrier stage of Haemophilus parasuis in naturally colonized pigs. Canadian J. Veter. Res. Accepted on March 14, 2013.

    A. Olvera, S. Pina, N. Macedo, S. Oliveira, V. Aragon, A. Bensaid, 2012. Identification of potentially virulent strains of Haemophilus parasuis using a multiplex PCR for virulence-associated autotransporters (vtaA). The Veter. J. 191:213–218.

    N. Macedo, S.R. Oliveira, A.P. Lage, J.L. Santos, M.R. Araujo, R.M. Guedes, 2011. ERIC-PCR genotyping of Haemophilus parasuis isolates from Brazilian pigs. Veter. J. 188:362-364.

    N. Macedo, G.M. Alghamdi, C.J. Gebhart, R.M. Guedes, 2008. Enteropatia proliferativa em Equinos. Ciência Rural. , v.38, p.889 - 897.

    Presentations
    An experimental model to evaluate the effect of antibiotics on Haemophilus parasuis colonization and immunity, 44th American Association of Swine Veterinarians, March 2 - 5, 2013

    Evaluation of the immunogenic and protective capacity of a transmembrane protein of Haemophilus parasuis, 22nd International Pig veterinary Society Congress, June 10 - 13, 2012

    Enrofloxacin treatment affects the colonization stage of Haemophilus parasuis in weaned pigs, AASV, March 10-13, 2012

    Development and validation of an ELISA test to detect antibodies against Haemophilus parasuis, AAVLD, September 29-October 5, 2011

    Awards
    Travel award, Veterinary Medicine Graduate Student Conference Travel Award, 2013

    J. Lindsay Oaks Bacteriology Award (Best Oral presentation). 54th Annual Conference of the American Association of Veterinary Laboratory Diagnosticians (AAVLD). September 29-October 5, 2011.

    Travel award: American Association of Veterinary Laboratory Diagnosticians (AAVLD) Foundation, 2011.

    University Innovations - University of Minnesota, 2011.

     

    CVMGRAD_marthaler image

    Marthaler, Doug

    marth027@umn.edu

    Degree
    B.S., Biology, Bemidji State University, 2003

    Adviser
    Dr. Sagar Goyal

    Research
    My research focuses on the prevalence of group A, B, and C rotavirus in the United States, with emphasis on the genetic diversity of group B and C rotavirus in the porcine population.

    Awards
    Office of Graduate Programs Enhanced Learning Travel Award, 2013

     

    Gage Matthews VMED

    Matthews, Gage

    gmatthew@umn.edu

    Degrees
    M.S., Chemical and Physical Biology, Vanderbilt University, 2012
    B.A., Biology, St. Olaf College, 2009

    Advisers
    Dr. Riki Sorge & Dr. Sandra Godden

    Research
    My research focuses on the control of mastitis in organic dairy cattle. This research focuses on the effectiveness of measures employed by these operations to limit the incidence of mastitis without the use of antibiotics.

     

    Nandita Mirajkar VMED Update

    Mirajkar, Nandita

    miraj001@umn.edu

    Degree
    B.V.Sc. & A.H., Bombay Veterinary College, Maharashtra Animal & Fishery Sciences University, India, 2010

    Adviser
    Dr. Connie Gebhart

    Research
    Swine Dysentery, caused by Brachyspira hyodysenteriae is a mucohemorragic diarrheal disease of grower-finisher pigs, responsible for significant economic losses globally. In addition, B. pilosicoli causes porcine intestinal spirochetosis, a chronic muco-diarrheal disease, and “B. hampsonii” causes a mucohemorrhagic diarrheal disease which is clinically indistinguishable from Swine Dysentery. Largely disappearing from the U.S. in the late 1980s, the disease has re-emerged across U.S. swine herds during the late 2000s. Broadly, I am interested in developing and implementing techniques useful in the diagnosis, prevention, control and treatment of porcine Brachyspira infections. My research involves validation of antimicrobial susceptibility testing techniques, their implementation for studying antimicrobial susceptibility patterns and investigation of potential resistance mechanisms of Brachyspira species. In addition, it involves molecular genotyping, phylogenetic analyses and molecular epidemiological studies to help elucidate the diversity, distribution, dissemination and potential evolutionary patterns of these pathogens. I am also interested in identifying potential virulence-associated genes/factors for B. hyodysenteriae and “B. hampsonii”, and their role in the pathogenesis of this disease.

    Presentations
    Mirajkar N.S. and Gebhart C.J. ‘Antimicrobial susceptibility patterns of Brachyspiraspecies in U.S. swine herds’. Oral presentation, 6th International Conference on Colonic Spirochaetal Infections, Surrey, U.K., 2013.

    Mirajkar N.S. and Gebhart C.J. ‘Molecular epidemiology of global Brachyspira hyodysenteriae isolates’. Oral presentation, 6th International Conference on Colonic Spirochaetal Infections, Surrey, U.K., 2013.

    Mirajkar N.S. and Gebhart C.J. ‘Association of Brachyspira antibiograms with species and source’. Oral presentation, 2013 Allen D. Leman Swine Conference, Saint Paul, U.S.A., 2013.

    Mirajkar N.S. and Gebhart C.J. ‘Validation of a broth microdilution method and investigation of in vitro antimicrobial susceptibilities of porcine Brachyspira species’. Oral presentation, 56th Annual Conference of the American Association of Veterinary Laboratory Diagnosticians, San Diego, California, U.S.A., 2013.

    Mirajkar N.S. and Gebhart C.J. ‘Molecular characterization and epidemiology ofBrachyspira hyodysenteriae in U.S. swine herds’. Oral presentation, 56th Annual Conference of the American Association of Veterinary Laboratory Diagnosticians, San Diego, California, U.S.A., 2013.

    Mirajkar N.S. and Gebhart C.J. ‘Molecular epidemiology of global Brachyspira hyodysenteriae isolates’. Poster presentation, CVM Points of Pride Research Day, University of Minnesota, Saint Paul, U.S.A. 2013.

    Awards

    MnDRIVE Global Food Supply Initiative Graduate Research Fellowship 2014-2015, awarded by the MnDRIVE, University of Minnesota, U.S.A.

    Travel Award for two oral presentations at the 6th International Conference on Colonic Spirochaetal Infections in U.K., provided by the VMED program, College of Veterinary Medicine, University of Minnesota, U.S.A.

    J. Lindsay Oaks Best Student Bacteriology Award, 56th Annual Conference of the American Association of Veterinary Laboratory Diagnosticians, San Diego, U.S.A., 2013.

    Trainee travel award for the 56th Annual conference of the American Association of Veterinary Laboratory Diagnosticians, San Diego, U.S.A., 2013.

    Best poster presentation award in the Emerging and Zoonotic Diseases program at the CVM UMN Points of Pride Research Day, Saint Paul, U.S.A, 2013.

    Young scientist award at the 6th International Conference on Colonic Spirochaetal Infections, Surrey, U.K., 2013.

    AAA Scholars Abroad Program 2011 Award from the American Alumni Association, India, 2011.

    Lotus Trust Graduate studies scholarship from the Lotus Trust foundation, India, 2011.

    S.K. Patil Scholarship from the Shri Brihad Bhartiya Samaj foundation, India, 2011.

    Travel award for graduate studies abroad from the Tatachem Golden Jubilee foundation, India, 2011.

    Graduate education abroad grant from the Pirojshah Godrej foundation, India, 2011.
     

     

     

    Hadia Mohammad VMED

    Mohammad, Hadia

    moham698@umn.edu

    Degrees
    M.S., Microbiology, Zagazig University, 2010
    B.S., Pharmacy, Zagazig University, 2004

    Adviser
    Dr. Pam Skinner 

    Research
    The mucosal surfaces are critical sites of transmission of both HIV & simian immunodeficiency virus (SIV). I believe that the ability of a vaccine to induce mucosal immunity is important in order to prevent or reduce the dissemination of HIV and SIV by providing a first line of defense.  Using the SIV-infected rhesus macaque as a model for HIV infection, my research focuses on evaluating the ability of CD8 T cell-vaccines to induce high levels of functional SIV-specific CD8 T cells in genital, rectal & lymphoid tissue.  I am determining the localization, abundance, and phenotype of SIV-specific CD8 T cells in situ in genital, rectal & lymphoid tissue of vaccinated and control animals.

     

    Eugene Nwaokorie VMED

    Nwaokorie, Eugene

    nwoko006@umn.edu

    Degrees
    M.S., Veterinary Medicine, University of Minnesota, 2010
    D.V.M., University of Nigeria, Nsukka, Nigeria, 1987

    Advisers 
    Dr. Carl Osborne & Dr. Jody Lulich

    Research
    My research interests focus on the epidemiology of urolithiasis in domestic animals. As a team we have worked on the epidemiology of urolithiasis in dogs, cats and ferrets. Now we are working on the epidemiology of urolithiasis in goats.  We plan to extend this study to sheep, cows, horses, pigs, rabbits and guinea pigs. Knowledge of these risk factors may facilitate development of surveillance strategies that result in earlier detection of urolithiasis in domestic animals as well as help in the design of effective diagnostic, therapeutic and prevention of this condition.

    Publications
    Osborne CA, Albasan H, Lulich JP, Nwaokorie EE et al. Quantitative Analysis of 4468 Uroliths Retrieved from Farm Animals, Exotic Species, and Wildlife Submitted to the Minnesota Urolith Center: 1981 to 2007.  Vet Clin North Am Small Anim Pact 2009; Vol.39, Issue 1: 65-78.

    Nwaokorie EE, Osborne CA, Lulich JP, Albasan H et al. Epidemiology of struvite uroliths in ferrets 272 cases (1981-2007). J Am Vet Med Assoc 2011; 339: 1319-1324.

    Osborne CA, Ulrich LK, Nwaokorie E E. Reactive versus empathic listening: what is the difference?  J Am Vet Med Assoc 2013; 242: 460-462.

    Nwaokorie EE, Osborne CA, Lulich JP, Albasan H et al.   Epidemiological evaluation of cystine urolithiasis in domestic ferrets (Mustela putorius furo):70 cases (1992-2009) J Am Vet Med Assoc 2013; 242: 1099-1103.  

     

    Catalina Picasso VMED

    Picasso, Catalina

    picas001@umn.edu

    Degree
    D.V.M., Universidad de la Republica Oriental del Uruguay. Facultad de Veterinaria, 2009

    Adviser
    Dr. Andres Perez

    Research
    The goal of my MsSc thesis is to characterize the spatial and temporal dynamics of bovine tuberculosis (BT), and to assess the nature and extent of the association between epidemiological factors and BT outbreaks in Uruguay. Results will contribute to design and implement risk-based surveillance strategies for BT in Uruguay and the United States.

     

    Luiza Ribeiro VMED

    Ribeiro Roos, Luiza

    ribei028@umn.edu

    Degree
    D.V.M., Universidade de Brasilia, 2013

    Adviser
    Dr. Maria Pieters

    Junjie Shao VMED

    Shao, Junjie

    jshao@umn.edu

    Degrees
    M.S., Pathogenic Organisms, Fudan University, 2005
    B.S., Forensic Medicine, Fudan University, 2002

    Adviser
    Dr. Yuying Liang

    Research
    I am working on the arenaviruses family, with a research focus on the interaction between viral proteins and host, and the pathogencity of the different GPC mutants of PICV.
     

    Tamer Sharafeldin VMED

    Sharafeldin, Tamer Ahmed

    shara022@umn.edu

    Degrees
    M.V.Sc., Zagazig University, Egypt, 2008
    B.V.Sc, Zagazig University, Egypt, 2004

    Advisers
    Dr. Sagar Goyal & Dr. Rob Porter

    Research
    I am studying pathogenesis and immunology of reovirus arthritis in turkeys. The virus has been isolated from tendons of 15 weeks old tom turkeys with lameness and ruptured tendons in 2011. We experimentally could reproduce the disease in turkeys. The virus induced tenosynovitis in gastrocnemius tendon sheath at 4 weeks post inoculation with no lameness. Lameness started in experimentally infected birds at 7 weeks post inoculation and % of lameness increased at 15 weeks post inoculation with tendon rupture in some turkeys. Further work is going on to study the pathogenesis of the virus and tissue spread using S4 gene copy number determination by rRT-PCR and immunohistochemisrty. Cytokine profile will be studied also in the infected birds. In addition, gastrocnemius tendon biomechanics will be evaluated in infected birds and electron microscopy will be used to report ultra structural changes in infected birds' tendons.

    Publications
    Mor, S.K., Sharafeldin, T.A., Abin, M., Kromm, M., Porter, R.E., Goyal, S.M. and Patnayak, D.P. (2013) The occurrence of enteric viruses in Light Turkey Syndrome. Avian Patholology, 42, 497-501 

    Mor, S.K., Sharafeldin, T.A., Porter, R.E., Ziegler, A., Patnayak, D.P. and Goyal, S.M. (2013) Isolation and characterization of a turkey arthritis reovirus. Avian Diseases, 57, 97-103

    Mostafa Y. Abdel-Glil, Sunil Kumar Mor, Tamer A. Sharafeldin, Rob Porter, and Sagar M. Goyal. Detection and characterization of Newcastle disease virus in formalin-fixed, paraffin-embedded tissues from commercial broilers in Egypt. Avian Diseases (2014). in press

    Sharafeldin T. A., Mor S. K., Bekele A. Z., Verma, H., Goyal S. M and Porter R. E. The role of reoviruses in turkey arthritis. Avian Pathology (2014). Submitted

    Tamer A. Sharafeldin, Sunil K. Mor, Harsha Verma, Aschalew Z. Bekele, Sagar M. Goyal and Robert E. Porterthogenicity of Turkey Arthritis Reoviruse in Chickens, Under review

    Tamer A. Sharafeldin, Sunil K. Mor, Harsha Verma, Aschalew Z. Bekele, Sally Noll, Sagar M .Goyal and Robert E. Porter, Long term pathogenicity of turkey arthritisreovirus (TARV) in turkeys, Under review

    Presentations

    Role of enteric viruses in light turkey syndrome (Oral presentation) in 62nd North Central Avian Disease Conference, Saint Paul, MN 2012

    Comparative pathogenecity of turkey arthritis reovirus in turkeys (Oral presentation) in 63rd North Central Avian Disease Conference, Saint Paul, MN 2013

    Comparative pathogenecity of turkey arthritis reovirus in turkeys (Poster presentation) in AAAP/AVMA annual conference, Chicago, IL 2013

    Long term pathogenicity of turkey arthritis reovirus in turkeys, North Central Avian Disease Conference (NCADC), 2014

    Pathogenesis of turkey arthritis reovirus, western conference of poultry diseases (WCPD), Puerto Vallarta, Mexico, 2014

    Awards
    Partnership and Ownership (ParOwn) 6 months fellowship to Veterinary Diagnostic Laboratory, University of Minnesota (2009)

    North Central Avian Disease Conference (NCADC) student travel award, 2014

    VMED graduate student travel award, spring, 2014, University of Minnesota

      

    Fernanda Shoyama VMED

    Shoyama, Fernanda

    fshoyama@umn.edu

    Degree
    B.S., Biological Sciences, Federal University of Uberlandia, Brazil

    Adviser
    Dr. Srinand Sreevatsan

    Publications

    Yaya Wang, Iftach Shaked, Stephanie M. Stanford, Wenbo Zhou, Julie M. Curtsinger, Zbigniew Mikulski, Zachary R. Shaheen, Genhong Cheng, Kristy Sawatzke, Amanda M. Campbell, Jennifer L. Auger, Hatice Bilgic, Fernanda M. Shoyama, David O. Schmeling, Henry H. Balfour Jr., Kiminori Hasegawa, Andrew C. Chan, John A. Corbett, Bryce A. Binstadt, Matthew F. Mescher, Klaus Ley, Nunzio Bottini, & Erik J. Peterson. The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity. Immunity, 2013 39(1), 111–122

    Silva, Alexandre L. Neves ; Adade, Camila M. ; Shoyama, Fernanda M. ; Neto, Cecílio Purcino S. ; Souto-Padrón, T. C. B. S. ; de Almeida, Mauro V. ; Rezende, Carlos A. de Magalhà es ; Silva, Claudio V. ; Souza, Maria A. . In vitro leishmanicidal activity of N-dodecyl-1,2-ethanediamine. Biomedicine & Pharmacotherapy, v. 66, p. 180-186, 2012.

     

    Grant Stoddard VMED

    Stoddard, Grant

    stodd038@umn.edu

    Degree
    B.S., Animal Science, University of Wisconsin-River Falls

    Advisers
    Dr. Gerard Cramer & Dr. Sandra Godden

    Jisun Sun VMED

    Sun, Jisun

    sunxx801@umn.edu

    Degrees
    M.S., Preventive Medicine, Kangwon National University, Republic of Korea, 2012
    D.V.M., Kangwon National University, Republic of Korea, 2010

    Adviser
    Dr. Peter Davies

    Research
    My research focuses on the prevalence investigation of Staphylococcus aureus including methicillin resistant Staphylococcus aureus (MRSA) in pig and swine veterinarian in U.S to evaluate colonization and infection patterns. We also have determined the predominant S.aureus genetic types using spa typing and MLST methods from isolates to understand the current distribution of this pathogen in pig industry.

    Award
    Office of Graduate Programs Travel Award, Fall 2013

     

    Dane Tatarniuk VMED

    Tatarniuk, Dane

    tatar014@umn.edu

    Degree
    D.V.M., University of Saskatchewan, 2011

    Adviser
    Dr. Troy Trumble

    Research
    My area of research is investigating intra-articular therapies for management of osteoarthritis in the horse, through use of measuring indirect immunologic biomarkers in synovial fluid. Specifically, my current investigation is focused on the intra-articular medication: autologous conditioned serum (more commonly known as 'IRAP').

    Awards
    2013 recipient of the American College of Veterinary Surgeons Foundation - Surgeon In-Training Grant, entitled: "Concentrations of Cytokines and Matrix Metalloproteinases in Serum and Synovial Fluid Following Injection of Autologous Conditioned Serum into Equine Osteoarthritic Distal Inter-Phalangeal Joints."

     

    Raffa Teixeira VMED

    Teixeira, Raffaella

    teixe005@umn.edu

    Degree
    D.V.M., Universidade Paulista, Brazil, 2004

    Adviser
    Dr. Molly McCue

    Research
    A correlation between the gray coat color and melanoma development has long been recognized with up to 80% of gray horses older than 15 years developing melanoma. Both graying and melanoma formation have been linked to a duplication in the Syntaxin 17 (STX17) gene, with the STX17 genotype affecting melanoma grade and severity in the Lipizzaner breed. An ASIP mutation, responsible for the bay/black coat color modifies melanoma risk in gray horses, with increased melanoma severity potentially due to an increase in MC1R pathway signaling. We have identified a population of gray Quarter Horses (QH) that appear to have a decreased melanoma risk. The objective of our study is to determine if the decreased incidence of melanoma in gray QH is related to decreased MC1R signaling resulting from the MC1R chestnut coat color allele. Identification of genetic factors that result in altered melanoma susceptibility will allow for more accurate assessment of prognosis and metastasis risk in horses with dermal melanomas.

    Presentations
    Genetic determinants of melanoma susceptibility in gray horses, 2012 ACVIM Forum, New Orleans, LA, May 31, 2012.

    Awards
    William and Deanna Pritchard Fellowship, 2013
    CVM Research Day Best Poster Award, 2013

     

    CVMGRAD_tousignant

    Tousignant, Steve

    tous0026@umn.edu

    Degrees
    D.V.M., University of Minnesota, 2011
    B.S., University of Minnesota, 2008

    Adviser
    Dr. Bob Morrison

    Research
    My research focus is on the epidemiology of PRRS virus in swine herds with an interest in risk factors of infection including spatial and temporal analysis and mapping. We have worked to develop a database of 10 production companies, of approximately 300 sow herds, representing nearly 1,000,000 sows in 14 states. Using this database, we have designed field trials to understand the effect of PRRS vaccination on the frequency and variety of PRRS viruses detected in air within a region. I have also conducted several trials on the role of oral vitamin D3 supplementation in suckling and post-weaned pigs and the response in performance and immune function.

    Publications
    Tousignant S., Henry S., Rovira A., Morrison R. Effect of oral vitamin D3 supplementation on growth and serum 25-hydroxy vitamin D levels in pigs up to 7 weeks of age (under review).

    Tousignant S., Morrison R. National PRRS project provides infection rate. National Hog Farmer Online, July 2012.

    Tousignant S., Morrison R. Are you ready for PRRS season? Pork Magazine, November 2012.

    Presentations
    Tousignant S., Morrison R. (2010). A survey of anaerobic digesters on swine farms (student poster session). American Association of Swine Veterinarians, Omaha, Nebraska.

    Tousignant S., Henry S., Morrison R. (2011). A field trial to determine effect of vitamin D oral supplementation (oral presentation). Allen D. Leman Swine Conference, St. Paul, MN.

    Tousignant S., Goede D., Morrison R. (2012). Identifying areas at high risk for epidemic spread of PRRS virus (oral presentation). Allen D. Leman Swine Conference, St. Paul, MN.

    Tousignant S., Morrison R. (2012). Sow herd PRRS incidence/prevalence project (oral presentation). Allen D. Leman Swine Conference, St. Paul, MN.

    Tousignant S., Rovira A., Morrison R. (2012). Reproduction of Peri Weaning Failure to Thrive Syndrome in weaned pigs and effect of supplemental vitamin D (oral presentation). Allen D. Leman Swine Conference, St. Paul, MN.

    Grants
    Morrison R., Tousignant S. (co-investigator). Impact of pig farm density on incidence of PRRS in a cohort of sow herds. National Pork Board. Funding begins October 2012.

    Morrison R., Tousignant S. (co-investigator). A pilot study to determine risk of PRRS infection from 3 years of retrospective data as a means of predicting future outbreaks in a large sample of US sow herds. College of Veterinary Medicine, Population systems signature series grant. Funding begins October 2012.

    Awards
    National Needs Fellowship in Food Animal Biosecurity: Infectious Disease Biology. Fellowship begins January 2013.

     

    Jo Varshney VMED

    Varshney, Jyotika

    varsh005@umn.edu

    Degrees
    M.S., Pathobiology, Pennsylvania State University, 2012
    BVSc. & A.H., Anand Agricultural University, India, 2009

    Adviser
    Dr. Subbaya Subramanian & Dr. David Largaespada

    Research
    Osteosarcoma is the most common primary bone malignancy affecting children, adolescents and young adults. Additionally, osteosarcoma is commonly found in canines, with approximately 10,000 new cases each year. The complex biology of osteosarcoma and tumor heterogeneity makes it challenging to identify effective new gene targets and therapeutic agents. We have found that a unifying feature of osteosarcoma is the overexpression of miR-17-92 microRNAs. We have deciphered that deregulation of 14q32miR/cMYC network leads to overexpression of miR-17-92 in osteosarcoma. This deregulation is associated with poorer outcomes in osteosarcoma and is preserved in naturally occurring canine osteosarcoma suggesting a conserved disease mechanism. Upregulation of miR-17-92 miRNAs contributes to osteosarcoma progression by targeting potential tumor suppressor osteosarcoma driver genes such as PTEN. Additionally, our studies show that the prodrug Minnelide inhibits cMYC expression and downregulates miR-17-92 miRNAs. Together, our data suggests that upregulation of miR-17-92 miRNAs contributes to osteosarcoma progression and Minnelide reduces tumor burden in osteosarcoma by inhibiting miR-17-92 expression.

    Publications
    Varshney, J.; Ooi, J.H.; Jayarao, B..M.; Istvan, A.; Fisher, J.; Smith, R.; Patterson, A.; Cantorna, M.T. White button mushrooms increase microbial diversity and accelerate the resolution of Citrobacter rodentium infection in mice. The Journal of Nutrition 143, no. 4 (2013): 526-532.

    Varshney J, Subramanian S. “MicroRNAs in Cancer.” Current Science. 2013

    Varshney J and Subramanian S. “MicroRNA gene regulation in osteosarcoma, Osteosarcoma: Symptoms, Diagnosis and Treatment Options.” Nova Publications. Book chapter.

    Presentations
    Platform presentation: cMYC transactivated miR-17-92 cluster plays a crucial role in osteosarcoma progression, 2013 International Conference on Advances in Canine and Feline Genomics and Inherited Diseases. Broad Institute at MIT Cambridge, USA

    Awards
    CVM Research Day Best Poster Award, University of Minnesota, Minneapolis, MN 2013

     

    Fuyuan Wang VMED

    Wang, Fuyuan

    wang3044@umn.edu

    Degrees
    M.S., Pharmacology, University of Minnesota, 2013
    M.S., Toxicology, University of Michigan, 2008
    M.E., Chemical Engineering, Tsinghua University, 2006
    D.V.M., Shandong Agricultural University, 2001

    Adviser
    Dr. Sabita Roy

    Research
    Alteration in gut microbiome has been shown to contribute to bowel dysfunction and gut barrier disruption. We have recently demonstrated that morphine treatment results in significant disruption in gut barrier function leading to increased translocation of gut commensal bacteria. Gut microbiome plays an important role in maintaining gut homeostasis. However, the effect of morphine on gut microbiome has not been investigated. Citrobacter rodentium is a natural mouse pathogen that models intestinal infection by enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) in humans and causes attaching and effacing (A/E) lesions and colonic hyperplasia. My research focuses on the effects of morphine treatment on host mucosal immunity, gut microbiota, and bacterial virulence in a Citrobacter rodentium-mouse model. My research will expand understanding of effects of morphine on the microbiome-neuroimmune axis, and of its role in the gut homeostasis.

    Publications 
    Zhan Y, Chen PJ, Sadler WD, Wang F, Poe SA, Eaton KA, Nunez G, Chen G. Gut Microbiota Protects against Gastrointestinal Tumorigenesis Caused by Epithelial Injury. Cancer Research. 2013, 73(24):7199-210.

    He X, Lyons DM, Toffaletti DL, Wang F, Qiu Y, Davis MJ, Meister DL, Dayrit JK, Lee A, Osterholzer JJ, Perfect JR, Olszewski MA. Virulence Factors Identified by Cryptococcus neoformans Mutant Screen Differentially Modulate Lung Immune Responses and Brain Dissemination. Am J Pathol. 2012, 181(4):1356-1366

    Qiu Y, Zeltzer S, Zhang Y, Wang F, Chen GH, Dayrit J, Murdock BJ, Bhan U, Toews GB, Osterholzer JJ, Standiford TJ, Olszewski MA. Early Induction of CCL7 Downstream of TLR9 Signaling Promotes the Development of Robust Immunity to Cryptococcal Infection. Journal of Immunology. 2012, 188(8):3940-3948

    Chen GY, Liu M, Wang F, Bertin J, Nunez G. A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. Journal of Immunology. 2011, 186(12):7187-7194.

    Zhang Y, Wang F, Bhan U, Huffnagle GB, Toews GB, Standiford TJ, Olszewski MA. TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans infected lungs. Am J of Pathol. 2010, 177(2):754-765. (co-first author)

    Zhang Y, Wang F, Tompkins KC, McNamara A, Jain AV, Moore BB, Toews GB, Huffnagle GB, Olszewski MA. Robust Th1- and Th17-Immunity Supports Pulmonary Clearance but Cannot Prevent Systemic Dissemination of Highly Virulent Cryptococcus neoformans H99. Am J of Pathol. 2009, 175(6):2489-2500.

    Wang F, Miao C, Liu Z. Effect of Electric Field on Cell Growth, Permeability, and Extracellular Enzymatic Activity of Phanerochaete chrysosporium, Chinese Journal of Process Engineering. 2007, 07(02): 86-90.

    Wang F, Diao Y. Isolation and Identification of Avian Escherichia coli from Chickens in Partial Regions of Shandong Province, Shandong Journal of Animal Science and Veterinary Medicine. 2002, 15(1):1-2.

    Presentations (Selected)

    Wang F, Sindberg G, Banerjee S, Ma J, Li D, Johnson T, Roy S. Morphine treatment shifts the mouse colonic microbiome and promotes systemic dissemination of Citrobacter rodentium. 20th Scientific Conference of Society on NeuroImmune Pharmacology (SNIP), New Orleans, Louisiana, March 26-29, 2014

    Wang F, Meng J, Roy S. Morphine Treatment Increases Citrobacter rodentium Virulence and Disrupts Infection Induced IL17a Immune Response in Mice. The 16th International Congress of Mucosal Immunology (ICMI 2013), Vancouver, BC, Canada, July 2013

    Liu M, Wang F, Shaw M, Nunez G, Chen GY. Nod1 functions in T cells to suppress inflammation-associated colorectal cancer. Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research, Chicago, IL. Mar 31-Apr 4, 2012. Cancer Res 2012;72(8 Suppl):Abstract nr 532. doi:1538-7445.AM2012-532

    Zhang Y, Wang F, Hardison SE, Love CK, Chen G, Osterholzer JJ, Wormley FL, Toews GB, Adler A, Williamson PR, Huffnagle GB, Olszewski, MA. Cryptococcal virulence factor Ssa1 interferes with the innate host responses by inducing the alternative activation of macrophages during the afferent phase of the immune response in the infected lungs. The General Meeting of the American Society for Microbiology, San Diego, May 2010

    Wang F, Olszewski MA, Zhang Y, Osterholzer JJ, Chen G, Zeltzer S, Huffnagle GB, Toews GB Bhan U, Standiford TJ. The Role of Toll-Like Receptor 9 (TLR9) in Anticryptococcal Host Defenses. The General Meeting of the American Society for Microbiology, Philadelphia, May 2009

    Awards
    Early Career Investigator Travel Award, Society on NeuroImmune Pharmacology (SNIP), 2014

    Office of Graduate Programs Enhanced Learning Travel Award, 2013

     

    Sylvia Wanzala VMED

    Wanzala, Sylvia

    wanza003@umn.edu

    Degrees
    M.Sc., Molecular Biology & Biotechnology, Makerere University, 2013
    D.V.M., Makerere University, 2005

    Adviser
    Dr. Srinand Sreevatsan

    Research
    My research will involve the comprehensive tracking of biomarkers for diagnostics and One Health. I will be working on zoonotic TB in humans and animals as well as testing the efficacy of a novel diagnostic tool on samples from these populations (wildlife, cattle and humans).

    Awards
    ICI3D Clinic on Dynamical Approaches to Infectious Disease Data travel award, 2014
    Fogarty Global Health Fellowship, 2012-2013

     

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