Teaching interests relate to the development of problem oriented courseware and web based learning aids that could have application in veterinary colleges world wide. Research interests center around stem cell biology. Current directions of research pertain to the development of Induced Pluripotent Stem cells and characterization of adult multipotent stem cell lines in large animal models which can be used for gene therapy (e.g. treatment of diabetes). Exploring stem cell treatment in a large animal model is a needed step toward our ultimate goal of translating this form of therapy to humans.
Selected Publications
Ph.D. Thesis
Clarkson, CE, Ph.D. Thesis: Tissue Culture as a Means of Establishing an Epidermal-Implant Union in Percutaneous Implants. Department of Veterinary Anatomy, College of Veterinary Medicine, Texas A&M University, College Station, TX, 1985
Peer Reviewed Papers
Rickers C, Gallegos R, Seethamraju R, Wang X, Swingen C, Jayaswal A, Rahrmann E, Kastenberg Z, Clarkson C, Bianco R, O’Brien T, Verfaillie C, Bolman R, Wilke N, Jerosch-Herold M: Applications of magnetic resonance imaging for cardiac stem Ccll therapy. J Interventional Cardiol 17(1), 2004
Torres SM, Feeney DA, Lekcharoensuk C, Fletcher TF, Clarkson CE, Nash NL, Hayden DW: Comparison of colloid, thyroid follicular epithelium, and thyroid hormone concentrations in healthy and severely sick dogs. J Am Vet Med Assoc. 222(8):1079-85, 2003
Abstracts
Towards Porcine Induced Pluripotent Stem Cells (iPS) for Biomedical Model Development. C. Hsieh, C.E. Clarkson. B. Ziemba, J. Dutton, M. Firpo, T. O’Brien, S. Fahrenkrug. Engineering Stem Cells Symposium. April 2008.
Characterization of Dog Mulit-Potent Adult Progenitor Stem Cells. A. Frantz, C. Clarkson, E. Rahrmann, Z. Kastenberg. L. Sandquist, M. Felten, A. Jayaswal, M. Reyes, C. Verfaillie, T. O’Brien. Points of Pride. 2008
Characterization of Dog Multi-Potent Adult Progenitor Stem Cells. Aric Frantz, Christina Clarkson, Eric Rahrmann, Zach Kastenberg, Lee Sandquist, Mike Felten, Avinash Jayaswal, Morayma Reyes, Catherine Verfaillie, Timothy O’Brien. Merial-NIH National Veterinary Scholars Symposium. Bethesda, MD. August 2007
Christina E. Clarkson, Eric Rahrmann, Zachary Kastenberg, Lee Sandquist, Mike Felten, Avinash Jayaswal, Morayma Reyes, Catherine Verfaillie, Timothy O’Brien. Preliminary Evidence of Multipotent Stem Cells Derived from Adult Canine Bone Marrow. International Society of Stem Cell Research. June 2006
Timothy O’Brien, Eric Rahrmann, Lee Sandquist, Zachary Kastenberg, Christina E. Clarkson, Robert Donahue, Catherine Verfaillie. Preliminary Evidence of Multipotent Stem Cells Derived from Adult Rhesus Macaque Bone Marrow. International Society of Stem Cell Research. June 2006
Reyes M, Ross J.R., Clarkson C. , Bergstrom R.A., Verfaillie C.M., Tranquillo, R.T. Coentrapment of MAPC-Derived Smooth Muscle and Endothelial Cells for Tissue-Engineered Arteries. American Society of Hematology. 2003
Robert Gallegos, Avinash Jayaswal, Christina Clarkson, Eric Rahrmann, Zach Kastenberg, James Xu, Richard Jones, Jenifer Gravelle, Xiaoen Wang, Michael Jerosch-Herold, R. Morton Bolman III, Tim O’Brien, Catherine Verfaillie; Bone Marrow Induced Myocardial Restoration in the Canine Model. American Society of Hematology. 2003
Robert Gallegos, X. Wang, A. Jayaswal, E. Rahrmann, R. Jones, Z. Kastenberg, J. Gravelle, X. Xu, C. Clarkson, C. Swingen, R. Seethamraju, N. Osman, Richard Bianco, Timothy D. O'Brien, Catherine M. Verfaillie, R. Morton Bolman, Michael Jerosch-Herold: MRI Demonstrates Improved Regional Myocardial Strain following Stem Cell Treatment in a Canine Infarct Model. American Heart Association. Orlando, Florida November, 2003
Robert P Gallegos, Cory Swingen, Xiaoen Wang, Christina E Clarkson, R. Morton Bolman: Serum Troponin Predicts Infarct Size University of Minnesota American Heart Association, San Antonio,Texas April 2003
Robert P Gallegos, Avinash Jayaswal, Christina Clarkson, Eric Rahrmann, Zack Kastenberg, Imran Al-Amin Ravi Teja Seethamraju, R. Morton Bolman, Catherine Verfaillie, Norbert Wilke: Myocardial Perfusion Reserve to Assess Cardiac Stem Cell Therapy. North Am Soc Cardiac Imaging. Houston, TX. September 2002.
Current Funding
SELEX generated probes for identification and isolation of swine Multipotent Adult Progenitor Cells; Prinicipal Investigator; Grant-in-Aid University of Minnesota 7/2007-1/2009
