John P. Collister
University of Minnesota
295 AS/VM Building
1988 Fitch Avenue
Saint Paul, MN 55108
B.S., University of Illinois
D.V.M., University of Illinois
Ph.D., University of Minnesota
Our lab studies hormone systems that interact with central nervous system regulation during hypertension and heart failure, two cardiovascular disease conditions that have high mortality and morbidity. Primarily, the lab is focused on the link between hormonal systems (such as the renin angiotensin system), central sites of action of these hormones and the regulation of sympathetic nervous system outflow. We have focused our attention on the plasma hormone, angiotensin II, and examined its role in blood pressure regulation and the pathophysiology of heart failure at 3 specific brain regions (the area postrema, subfornical organ and organum vasculosum of the lamina terminalis) known as circumventricular organs. These areas lack the normal blood brain barrier and are therefore accessible by circulating peptide hormones. It is thought that hormones, such as angiotensin II act at these sites, cause downstream neural activation of the sympathetic nervous system, which in turn is linked to hypertension and chronic decreases in myocardial function after myocardial infarction. We use the rat as a model of hypertension or heart failure in our experiments. We also use state of the art radiotelemetry to continuously measure arterial pressure and heart rate in conscious, freely moving, rats for up to 6 months, and echocardiography to measure ejection fractions in rats with post myocardial infarctions. My collaborations involve direct interactions with physiologists, pathologists and cardiologists primarily but also I have a current collaboration with Dr. Al Beitz examining the effects of electroacupuncture on the long term hypertensive effects of angtiotensin II in the rat.
(For a comprehensive list of Dr. Collister's recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Collister, J.P., Hornfeldt, B.J., Osborn, J.W., Hypotensive response to losartan in normal rats: role of AngII and the area postrema. Hypertension. 27(part 2): 598-606, 1996.
Collister, J.P., Osborn, J.W., Area postrema lesion attenuates the long-term hypotensive effects of losartan in salt-replete rats. Am. J. Physiol. 274: R357-R366, 1998.
Xu, L., Collister, J.P., Osborn, J.W., Brooks, V.L., Effects of losartan on sympathetic activity and heart rate in sodium deprived rats: role of the area postrema. Am. J. Physiol. 275: R46-R55, 1998.
Collister, J.P., Osborn, J.W., The area postrema does not modulate the long-term salt-sensitivity of arterial pressure. Am. J. Physiol. 275: R1209-R1217, 1998.
Carlson, S., Collister, J.P., Osborn JW. The area postrema modulates hypothalamic Fos responses to intragastric hypertonic saline in conscious rats. Am. J. Physiol. 275: R1921-R1927, 1998.
Osborn, J.W., Collister, J.P., Carlson, S.H., Angiotensin and osmoreceptor in puts to the area postrema: Role in long-term control of fluid homeostasis and arterial pressure. Clin. Exp. Pharm. Physiol. 27: 443-449, 2000.
Collister, J.P., Osborn, J.W., The chronic infusion of hexamethonium and phenylephrine to effectively clamp the sympathetic nervous system. J. Pharm. Toxicol. Methods. 42: 135-147, 2001.
Collister, J.P., Soucheray, S.L., Osborn, J.W., Chronic hypotensive effects of losartan are not dependent on the actions of angiotensin II at AT2 receptors. J. Cardiovasc. Pharm. 39:107-116, 2002.
Collister, J.P., Hendel, M.D., Role of the subfornical organ in the chronic hypotensive response to losartan in normal rats. Hypertension. 41: 576-582, 2003.
Osborn, J.W., Ariza-Nieto, P., Collister, J.P., Soucheray, S., Zimmerman, B., Katz, S., Responsiveness vs. basal activity of plasma ANGII as a determinant of arterial pressure and salt sensitivity. Am. J. Physiol. 285: H2142-H2149, 2003.
Collister, J.P., Hendel, M.D., The role of Ang (1-7) in mediating the chronic hypotensive effects of losartan in normal rats. JRAAS. 4: 176-179, 2003.
Collister J.P., Hendel, M.D., Subfornical organ lesion attenuates chronic hypotensive effects of losartan in salt-replete rats. JRAAS. 4: 207-212, 2003.
Hendel, M. D. and J. P. Collister. Contribution of the Subfornical Organ to Angiotensin II Induced Hypertension. Am J Physiol Heart Circ Physiol. 288(2): H680-H685, 2005.
Hendel, M. D. and Collister, J. P., Sodium balance, arterial pressure and the role of the subfornical organ during chronic changes in dietary salt. Am J Physiol Heart Circ Physiol. 289(1): H426-H431, 2005.
Collister, J. P. and Hendel, M.D., Chronic effects of angiotensin II and AT1 receptor antagonists in subfornical organ lesioned rats. Clinical and Experimental Pharmacology and Physiology, 32(5-6): 462-466, 2005.
Collister, J. P. and Osborn, J. W., The chronic hypotensive effects of losartan and the role of a responsive sympathetic nervous system. J. Cardiovasc. Pharm. 46(2): 147-154, 2005.
Jacob, F., M. D. Hendel, J. P. Collister, J. Armstrong, L. A. Clark, P. Ariza Guzman, W. Engeland, and J. W. Osborn. Neurally-mediated hypertension in the DOCA-salt model is independent of the subfornical organ. Brain Res. 1109: 74-82, 2006.
Hendel, M. D. and J. P. Collister. Role of the renal nerves in chronic angiotensin II induced hypertension. Clinical and Experimental Pharmacology and Physiology. 33: 1225-1230, 2006.
Nahey, D. B. and J. P. Collister. AngII-induced hypertension and the role of the area postrema during increased dietary salt. Am. J. Physiol. 292(1): H694-H700, 2007.
Ployngam, T. and J. P. Collister. An intact median preoptic nucleus is necessary for chronic angiotensin II induced hyptertension. Brain Res. 1162: 69-75, 2007.
Osborn, J. W., J. P. Collister, and P. Guzman. Effect of peripheral sympathetic nerve dysfunction on salt sensitivity of arterial pressure. Clinical and Experimental Pharmacology and Physiology, 35(3): 273-279, 2008.
Nahey, D. B. and J. P. Collister. Changing dietary sodium alters the chronic cardiovascular effects of losartan in rats. JRAAS. 9(1): 10-16, 2008.
Ployngam, T. and J. P. Collister. Role of MnPO neurons in the hypertensive response to chronic angiotensin II infusion. Brain Res. 1238: 75-84, 2008.
Collister, J. P. and D. B. Nahey. Combined roles of the area postrema and subfornical organ in the chronic hypotensive response to losartan. Brain Res. (In Press), 2009.
Collister, J. P. and D. B. Nahey. Simultaneous administration of Ang(1-7) or A-779 does not effect the chronic hypertensive effects of AngII in normal rats. JRAAS. (In Press), 2009.
Ployngam, T. and J. P. Collister. Role of the median preoptic nucleus in chronic angiotensin II-induced hypertension. Brain Res. 1238: 75-84, 2008.
Collister, J. P. and D. B. Nahey. The cardiovascular response of normal rats to dual lesion of the subfornical organ and area postrema at rest and to chronic losartan. Brain Res. 1302: 118-124, 2009.
Collister, J. P. and D. B. Nahey. Simultaneous administration of Ang(1-7) or A-779 does not effect the chronic hypertensive effects of AngII in normal rats. JRAAS. 11(2): 99-102, 2010.
Ployngam, T., S. A. Katz, and J. P. Collister. Role of the median preoptic nucleus in the chronic hypotensive effect of losartan in sodium-replete normal rats. Clinical and Experimental Pharmacology and Physiology. 37(1): e7-13, 2010.
Vieira A. A., D. B. Nahey, and J. P. Collister. Role of the organum vasculosum of the lamina terminalis for the chronic cardiovascular effects produced by endogenous and exogenous ANG II in conscious rats. Am J Physiol Regul Integr Comp Physiol. 299: R1564-R1571, 2010.
Meehan, J. and J. P. Collister. Role of the subfornical organ in mediating hyopothalamic neuronal activation in response to angiotensin II. Open J. Neuroscience. 1(1): 1-10, 2011.
Osborn, J. W., Hendel, M., J. P. Collister and G. D. Fink. Role of the subfornical in angiotensin II-salt hypertension. Exp. Physiol., 97(1): 80-88, 2012.
Ployngam, T., S. S. Katz, and J. P. Collister. Role of the median preoptic nucleus in arterial pressure regulation and sodium and water homeostasis during high dietary salt intake. Neurophysiology. 44(5): 363-375, 2012.
Collister, J. P., D. B. Nahey, M. D. Hendel, and V. Brooks. Roles of the subfornical organ and area postrema in arterial pressure increases induced by 48 hours water deprivation in normal rats. Physiol. Reports, 2(1) (e00191): 1-9, 2014.
Collister. J. P., M. Bellrichard, D. Drebes, D. Nahey, J. Tian, and M. C. Zimmerman. Overexpression of copper/zinc superoxide dismutase in the median preoptic nucleus attenuates chronic angiotensin II-induced hypertension in the rat. Int. J. Mol. Sci. 15: 22203-22213, 2014.
University of Minnesota Grant In AID. "Role of electroacupuncture in the prevention of chronic AngII mediated hypertension" 07/01/12-01/15/14. $27,052.
USDA Hatch Formula Funds. “Critical role of ROS in the median preoptic nucleus in the development of heart failure” 10/1/13-9/30/15. $49,992.
Honors and Awards
Graduate School Fellowship, University of Minnesota. 1994.
Liz Atac Award for Graduate School Excellence and Community Service. 1997.
American Physiological Society Neural Control & Autonomic Regulation Section—Michael J. Brody Young Investigator Award. 1999.
The American Physiological Society Arthur C. Guyton Award for Excellence in Integrative Physiology, 2003.