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  Home > VBS Faculty > Kent Reed
 

Kent Reed

PUB/CVM/VBS/Kent_Reed_2011

 

295 Animal Science/Veterinary Medicine

1988 Fitch Avenue

University of Minnesota

St. Paul, MN 55108

 

e-mail: reedx054@umn.edu
http://www.tc.umn.edu/~reedx054/

 

Education

B.S., University of Minnesota
M.S., Fort Hays State University
Ph.D., Texas A&M University
Post-Doctoral, University of Rochester, University of WisconsinMilwaukee

Research Interests

My research is dedicated to the application of molecular and cytogenetic approaches to the study of genomics, immunogenetics and evolution. I have broad training in genetics, evolutionary biology and molecular biology with 12 years of experience working in avian genomics and poultry science. My laboratory has led the effort to develop genetic resources for the turkey, culminating in a medium density genetic linkage map in support of the recent assembly and analysis of a draft genome sequence. We are part of an ongoing effort to complete the sequence of the turkey genome using next-generation sequencing. Additional research is directed towards the application of these genomic resources for collaborative functional investigations in muscle physiology, immunology and toxicology. Projects have included a comprehensive approach to investigation of muscle function and development as it relates to meat production and an examination of gene expression associated with cardiomyopathy (Round Heart Disease). A second project focuses on the structure and evolution of the turkey major histocompatibility complex (MHC). The main objectives of this project are to sequence the turkey MHC; identify important haplotypes; develop and trial assays for genetic testing of commercial and experimental populations; and explore expression of key genes. Our efforts have made the turkey one of the better characterized avian species at the MHC. We are currently using RNA-seq approaches to better understand the metabolic and immunological responses of turkey to probiotic and aflatoxin exposure. These studies are aimed at mitigating the effects of mycotoxin contaminants in feed.

Selected Publications 


(For a comprehensive list of  Dr. Reed's recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

 

Nierobisz LS, Sporer KRB, Strasburg GM, Reed KM, Velleman SG, Ashwell CM, Felts JV, and PE Mozdziak. 2012. Differential expression of genes characterizing myofiber phenotype. Anim Genet. 43:298-308. Epub 19 September 2011 | DOI: 10.1111/j.1365-2052.2011.02249.x.


Velleman SG, Sporer KRB, Ernst CW, Reed KM, and Strasburg GM. 2012. Versican, matrix Gla protein, and death-associated protein expression affect muscle satellite cell proliferation and differentiation. Poult Sci. 91:1964-1973.


Eimes JA, Reed KM, Mendoza KM, Bollmer JL, Whittingham LA, Bateson ZW and PO Dunn. 2013. Greater prairie-chickens have a compact MHC-B with a single class IA locus. Immunogenetics, 65:133-144. Published online 20 November 2012.


Kim JE, Bunderson BR, Croasdell A, Reed KM, and Coulombe RA Jr. 2013. Alpha-class glutathione S-transferases in wild turkeys (Meleagris gallopavo): Molecular and functional characterization and role in resistance to the carcinogenic mycotoxin aflatoxin B1. PLoS ONE, 8(4): e60662. doi:10.1371/journal.pone.0060662


Malila Y, Tempelman RJ, Sporer KRB, Ernst CW, Velleman SG, Reed KM and Strasburg GM. 2013. Microarray analysis of differential gene expression between normal and pale, soft and exudative turkey meat. Poult Sci. 92:1621-1633; doi:10.3382/ps.2012-02778.


Monson MS, Mendoza KM, Velleman SG, Strasburg GM, and Reed KM. 2013. Expression profiles for genes in the avian MHC B-Locus. Poult Sci. 92:1523-1534; doi:10.3382/ps.2012-02951.


Bunderson BR, Kim JE, Croasdell A, Mendoza KM, Reed KM and Coulombe RA, Jr 2013. Heterologous expression and functional characterization of avian mu-class glutathione S-transferases. Comp Biochem Physiol. Part C: Toxicology, 158:109–116. doi:10.1016/j.cbpc.2013.05.007.
 

Bauer MM, Miller MM, Briles WE, and Reed KM. 2013. Estimating genetic diversity at the MHC in introduced wild turkeys. Anim Biotech. 24:210-228.
 

Adams S, Xing Z, Li J, Mendoza K, Perez D, Reed K, and Cardona C. 2013. The effect of avian influenza virus NS1 allele on virus replication and innate gene expression in avian cells. Mol Immunol. 56(4):358-368. doi: 10.1016/j.molimm.2013.05.236. Epub 2013 Aug 1.
 

Reed KM, Mendoza KM, Fleege EC, Damerow JA and Armién AG. 2013. Evaluation of CHD7 as a candidate gene for choanal atresia in alpaca (Vicugna pacos). Vet J, 198:295-298. doi: 10.1016/j.tvjl.2013.07.006. Epub 2013 Aug 9.


Dalloul RA, Zimin AV, Settlage RE, Kim S, and Reed KM. 2014. Next generation sequencing strategies for characterizing the turkey genome. Poult Sci. 93:479–484.


Malila Y, Carr KM, Ernst CW, Velleman SG, Reed KM, and Strasburg GM. 2014. Deep transcriptome sequencing reveals differences in global gene expression between normal and pale, soft and exudative (PSE) turkey meat. J Anim Sci. 2014 Feb 4. [Epub ahead of print].


Monson MS, Settlage RE, McMahon KW, Mendoza KM, Rawal S, El-Nemazi HS, Coulombe RA Jr., and Reed KM. 2014. Response of the hepatic transcriptome to aflatoxin B1 in domestic turkey (Meleagris gallopavo). PLoS One, Jun 30;9(6):e100930. doi: 10.1371/journal.pone.0100930.
 

Rawal S, Bauer MM, Mendoza KM, El-Nezami H, Hall JR, Kim JR, Stevens JR, Reed KM, and Coulombe, RA. 2014. Aflatoxicosis chemoprevention by probiotic Lactobacillius and lack of effect on the major histocompatibility complex. Res Vet Sci, pii: S0034-5288(14)00170-2. doi: 10.1016/j.rvsc.2014.06.008.
 

Reed KM, Benoit B, Wang X, Greenshields M, Hughes C, and Mendoza KM. 2014. Conserved MHC gene orthologs genetically map to the turkey MHC-B. Cytogenet Genome Res. 2014;144(1):31-8. doi: 10.1159/000366440. Epub 2014 Sep 23.


Monson MS, Settlage RE, Mendoza KM, Rawal S, El-Nezami HS, Coulombe RA Jr., and Reed KM. Modulation of the spleen transcriptome in domestic turkey (Meleagris gallopavo) in response to aflatoxin B1 and probiotics. Immunogenetics, in press.

Current Funding

"Influence of thermal challenge on turkey muscle development and meat quality." USDA-NIFA-AFRI. 2014-2017 (co-PD w/Strasburg and Velleman).

"Functional genomics to enhance aflatoxin resistance in poultry." USDA-NIFA-AFRI. 2013-2016, (co-PD w/Coulombe).

Current Students

Melissa Monson, CMB PhD Student, Inflammatory Immune Responses to Aflatoxin in the Turkey (Meleagris gallopavo)
 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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