St. Paul, MN 55108
B.A., Hood College
Ph.D., University of Minnesota
My research interests are focused on mechanisms of pain signaling. We are examining changes in sensory neurons that are induced by peripheral tissue damage and contribute to the development of persistent pain. One research program that is currently underway is focused on the neuropeptide precursor VGF. VGF peptides are involved in neuroplasticity, but their mechanisms of action are completely unknown. We found that VGF peptides participate in spinal pain mechanisms through activation of microglia, the resident macrophages of the nervous system. We are presently examining the signaling pathways that mediate the effects of VGF peptides and the potential role of these peptides in chronic pain. Other lines of investigation that we are involved in include neuro-keratinocyte interactions and their contribution to hypersensitivity, the development of viral vectors for targeting of proteins that participate in pain pathways, and neuro-immune interactions in the intestine.
L. Vulchanova, D. Schuster, L. Belur, M. S. Riedl, K. M. Podetz-Pedersen, K. F. Kitto, G. L. Wilcox, R. S. McIvor, C. A. Fairbanks. Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture. Mol Pain. 2010 May 28;6:31.
M.S. Riedl, P.D. Braun, K.F. Kitto, S.A. Roiko, L.B. Anderson, C.N. Honda, C.A. Fairbanks, L. Vulchanova. Proteomic Analysis Uncovers Novel Actions of the Neurosecretory Protein VGF in Nociceptive Processing. Journal of Neuroscience, 29(42):13377, 2009
L. Vulchanova, M.A. Casey, G.W. Crabb, W. R. Kennedy and D.R. Brown. Anatomical evidence for enteric neuroimmune interactions in Peyer's patches. J. Neuroimmunol., 185(1-2):64-74, 2007.
Vulchanova, L., T.H. Olson, L.S. Stone, M.S. Riedl, R. Elde and C.N. Honda. (2001) Cytotoxic targeting of isolectin IB4-binding sensory neurons. Neuroscience, 108:143-55.
Guo, A., L. Vulchanova, J. Wang, X. Li and R. Elde. (1999) Immunocytochemical localization of the vanilloid receptor 1 (VR1): relashioship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur. J. Neurosci., 11:946-958.
L. Vulchanova, M. S. Riedl, S. J. Shuster, L. S. Stone, K. M. Hargreaves, G. Buell, A. Surprenant, R.A. North and R. Elde. (1998) P2X3 is expressed by DRG neurons that terminate in inner lamina II. Eur. J. Neurosci., 10:3470-3478.
Cook, S.P., L. Vulchanova, K. M. Hargreaves, R. Elde and E. W. McCleskey (1997) Distinct ATP receptors on pain-sensing and stretch-sensing neurons. Nature, 387:505-508.
“VGF, critical role in the transition from acute to chronic pain”, NIH/NIDA