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  Home > VPM Faculty > Timothy D. O'Brien

Timothy D. O'Brien

CVMVMC2 – Image – 180x222 – Timothy O'Brien


Contact Information:
Phone: 612-625-8175
Email: obrie004@umn.edu

Veterinary Diagnostic Laboratory
E220 VetDL
1333 Gortner Avenue
St. Paul, MN  55108

B.S. University of Minnesota (1976)
D.V.M. University of Minnesota (1978)
Ph.D. University of Minnesota (1985)

Board Certification
Diplomate, American College of Veterinary Pathologists (Anatomic Pathology, 1984)

Research Interests

  • Development, characterization, and clinical applications of adult bone marrow and adipose derived mesenchymal stem cells in large animal model species and species of veterinary interest
  • Development, characterization, and clinical applications of induced pluripotent stem cells in large animal model species and species of veterinary interest
  • Pathogenesis of diabetes mellitus and development of novel therapies for diabetes

Clinical Interests

  • Surgical pathology including oncologic pathology and dermatopathology

Instructional areas

  • Veterinary pathology: amyloidosis and diseases of the endocrine system
  • Surgical and comparative pathology


For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine and the National Institutes of Health, and  Google Scholar.

Current Funding

1) AKC-Canine Health Foundation (T.D. O’Brien, PI) 01/01/2009-12/31/2010
Canine Non-Hodgkin Lymphoma: Characterization and Prognostic Value of Cancer Stem Cells
Role: PI (5% FTE)

2) Morris Animal Foundation Fellowship Training Grant 09/01/2009-08/31/2011
D09CA-405 (J.F. Modiano, PI)
Enrichment for Canine Cancer Stem Cells by In Vitro Manipulation and Chemotherapy
Role: Co-Investigator (2% FTE)

3) NIH 2R44DK69865-05 (K.K. Papas, PI) 1/30/08-1/30/2011
Islet culture shipping and infusion device
Role: Co-Investigator (4% FTE)

4) Lilly-Minnesota-Purdue-Indiana Veterinary Translational Medicine—Animal Models of Human Disease Program 11/01/2010-10/30/2012
Valspodar-Mediated Ablation of Tumor Initiating Cells: Proof of Principle Study in Canine DLBCLL.
Role: Co-PI

Honors and Awards

  • Society of Phi Zeta National Research Award, 1984.
  • College of Veterinary Medicine Mark of Excellence Award for Research, 1998

Current Students

  • Aric Frantz, PhD, 2011
  • Chia-Jung Hsieh, PhD, 2011 



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